Annals of Diagnostic Pathology
Volume 10, Issue 1 , Pages 36-38 , February 2006

Detection of TLS/FUS-CHOP fusion transcripts in a case of oral liposarcoma

  • Elena Riet Correa Rivero, MDS, PhD

      Affiliations

    • Department of Oral Pathology, School of Dentistry, University of São Paulo, 05508-900 São Paulo, Brazil
    • ,
  • Ricardo Alves Mesquita, PhD

      Affiliations

    • Department of Oral Pathology, School of Dentistry, University of Minas Gerais, 31270-901 Belo Horizonte, Brazil
    • ,
  • Suzana Cantanhede Orsini Machado de Sousa, PhD

      Affiliations

    • Department of Oral Pathology, School of Dentistry, University of São Paulo, 05508-900 São Paulo, Brazil
    • ,
  • Fabio Daumas Nunes, PhD

      Affiliations

    • Department of Oral Pathology, School of Dentistry, University of São Paulo, 05508-900 São Paulo, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 11 3091 7902; fax: +55 11 3818 7894.

References 

  1. Enzinger FM, Weiss SW. Liposarcoma. In:  Enzinger FM,  Weiss SW editor. Soft tissue tumors. 3rd ed.. St Louis: CV Mosby; 1995;p. 431–466
  2. Orita Y, Nishizaki K, Ogawara T, et al. Liposarcoma of the tongue: case report and literature update. Ann Otol Rhinol Laryngol. 2000;109:683–686
  3. Gagari E, Kabani S, Gallagher GT. Intraoral liposarcoma: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endo. 2000;89:66–72
  4. Piattelli A, Di Alberti L, Favia GF. Liposarcoma involving the periodontal tissues. A case report. J Periodontol. 2000;71:322–324
  5. Favia G, Maiorano E, Orsini G, et al. Myxoid liposarcoma of the oral cavity with involvement of the periodontal tissues. J Clin Periodontol. 2001;28:109–112
  6. Hisaoka M, Tsuji S, Morimitsu Y, et al. Detection of TLS/FUS-CHOP fusion transcripts in myxoid and round cell liposarcomas by nested reverse transcription–polymerase chain reaction using archival paraffin-embedded tissues. Diagn Mol Pathol. 1998;7:96–101
  7. Schneider-Stock R, Rys J, Walter H, et al. A rare chimeric TLS/FUS-CHOP transcript in a patient with multiple liposarcomas: a case report. Cancer Genet Cytogenet. 1999;111:130–133
  8. Panagopoulos I, Mertens F, Isaksson M, et al. A novel FUS/CHOP chimera in myxoid liposarcoma. Biochem Biophys Res Commun. 2000;279:838–845
  9. Sanchez GI, Rabbitts TH. Transcription activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities. Proc Natl Acad Sci U S A. 1994;91:7869–7873
  10. Zinszner H, Albalat R, Ron D. A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP. Genes Dev. 1994;8:2513–2526
  11. Kuroda M, Ishida T, Horiuchi H, et al. Chimeric TLS/FUS-CHOP gene expression and the heterogeneity of its junction in human myxoid and round cell liposarcoma. Am J Pathol. 1995;147:1221–1227
  12. Lewis F, Maughan NJ, Smith V, et al. Unlocking the archive—gene expression in paraffin-embedded tissue. J Pathol. 2001;195:66–71
  13. Adams V, Hany MA, Schmid M, et al. Detection of t(11;22)(q24;q12) translocation breakpoint in paraffin-embedded tissue of the Ewing's sarcoma family by nested reverse transcription–polymerase chain reaction. Diagn Mol Pathol. 1996;5:107–113
  14. Edwards RH, Chatten J, Xiong Q-B, et al. Detection of gene fusion in rhabdomyosarcoma by reverse transcriptase–polymerase chain reaction assay of archival sample. Diagn Mol Pathol. 1997;6:91–97
  15. Perez-Losada J, Pintado B, Gutierrez-Adan A, et al. The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice. Oncogene. 2000;19:2413–2422
  16. Foss RD, Guha-Thakurta N, Conran RM, et al. Effects of fixative and fixation time on the extraction and polymerase chain reaction amplification of RNA from paraffin-embedded tissue. Comparison of two housekeeping gene mRNA controls. Diagn Mol Pathol. 1994;3:148–155
  17. Jordan RCK, Daniels TE, Greenspan JS, et al. Advanced diagnostic methods in oral and maxillofacial pathology. Part I: molecular methods. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:650–669

PII: S1092-9134(05)00047-X

doi: 10.1016/j.anndiagpath.2005.04.006

Annals of Diagnostic Pathology
Volume 10, Issue 1 , Pages 36-38 , February 2006

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