Annals of Diagnostic Pathology
Volume 10, Issue 3 , Pages 140-143 , June 2006

Mixed small cell carcinomas of the uterine cervix: prognostic impact of focal neuroendocrine differentiation but not of Ki-67 labeling index

  • Lars-Christian Horn, MD, PhD

      Affiliations

    • Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Leipzig D-04103, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 341 97 150 46; fax: +49 341 97 150 09.
    • ,
  • Bettina Hentschel, MA

      Affiliations

    • Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig D-04103, Germany
    • ,
  • Karl Bilek, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Leipzig, Leipzig D-04103, Germany
    • ,
  • Christine E. Richter, MD

      Affiliations

    • Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Leipzig D-04103, Germany
    • Department of Obstetrics and Gynecology, University of Leipzig, Leipzig D-04103, Germany
    • ,
  • Jens Einenkel, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Leipzig, Leipzig D-04103, Germany
    • ,
  • Cornelia Leo, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Leipzig, Leipzig D-04103, Germany

References 

  1. Abeler VM, Holm R, Nesland JM, Kjörstad KE. Small cell carcinoma of the cervix. A clinicopathologic study of 26 patients. Cancer. 1994;73:672–677
  2. Horn LC, Fischer U, Bilek K. Neuroendocrine carcinomas of the cervix uteri. Zentralbl Gynakol. 1996;118:679–683
  3. Stoler MH, Mills SE, Gersell DJ, Walker AN. Small-cell neuroendocrine carcinoma of the cervix. A human papillomavirus type 18–associated cancer. Am J Surg Pathol. 1991;15:28–32
  4. Albores-Saavedra J, Ashfaq R, Henson DE. Carcinoid and small cell carcinomas of the uterine cervix. Lab Invest. 1996;74:87–91
  5. Masumoto N, Fujii T, Ushikawa M, Saito M, Iwata T, Fukuchi T, et al. p16 overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix. Hum Pathol. 2003;34:778–783
  6. Pillai MR, Jayaprakash PG, Nair MK. Tumour-proliferative fraction and growth factor expression as markers of tumour response to radiotherapy in cancer of the uterine cervix. J Cancer Res Clin Oncol. 1998;124:456–466
  7. Van de Putte G, Kristensen GB, Lie AK, Baekelandt M, Holm R. Cyclins and proliferation markers in early squamous cervical carcinoma. Gynecol Oncol. 2004;92:40–46
  8. Avall-Lundqvist EH, Silfversward C, Aspenblad U, Nilsson BR, Auer GU. The impact of tumour angiogenesis, p53 overexpression and proliferative activity (MIB-1) on survival in squamous cervical carcinoma. Eur J Cancer. 1997;33:1799–1804
  9. Horn LC, Bilek K. The usefulness of tumor registry in cervical cancer. Zentralbl Gynakol. 2001;123:311–314
  10. Horn LC, Fischer U, Bilek K. Pathologic-anatomic description and basic morphological information for management of dysplasias and carcinomas of the cervix uteri. Zentralbl Gynakol. 2001;123:255–265
  11. Albores-Saaverdra J, Lazarra O, Poucell S, Rodriguez-Martinez HA. Primary carcinoid of the uterine cervix. Patologia. 1972;10:185–193
  12. Conner MG, Richter H, Moran C, Hameed A, Albores-Saaverdra J. Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. Ann Diagn Pathol. 2002;6:345–348
  13. Straughn JM, Richter HE, Conner MG, Meleth S, Barnes MN. Predictors of outcome in small cell carcinoma of the cervix—a case series. Gynecol Oncol. 2001;83:216–220
  14. Viswanathan AN, Deavers MT, Jhingran A, Ramirez PT, Levenback C, Eifel PJ. Small cell neuroendocrine carcinoma of the cervix: outcome and pattern of recurrence. Gynecol Oncol. 2004;93:27–33
  15. Chavez-Blanco A, Taja-Chayeb L, Cetina L, Chona-Vilchis G, Trjo-Becerril C, Perez-Cardenas E, et al. Neuroendocrine marker expression in cervical mixed carcinomas of non–small cell type. Int J Gynecol Pathol. 2002;21:368–374
  16. Boruta DM, Schorge JO, Duska LA, Crum CP, Castrillon DH, Sheets EE. Multimodality therapy in early-stage neuroendocrine carcinoma of the uterine cervix. Gynecol Oncol. 2001;81:82–87
  17. Kusayanagi S, Konishi K, Maysaka N, Sasaki K, Kurahashi T, Kaneko K, et al. Primary small cell carcinoma of the stomach. J Gastroeneterol Hepatol. 2003;18:743–747
  18. Okudela K, Ito T, Kameda Y, Nakamura N, Kitamura H. Immunohistochemical analysis for cell proliferation–related protein expression in small cell carcinoma of the esophagus; a comparative study with small cell carcinoma of the lung and squamous cell carcinoma of the esophagus. Histol Histopathol. 1999;14:479–485
  19. Graflund M, Sorbe B, Karlsson M. MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome. Int J Oncol. 2002;20:1041–1047

PII: S1092-9134(05)00125-5

doi: 10.1016/j.anndiagpath.2005.07.019

Annals of Diagnostic Pathology
Volume 10, Issue 3 , Pages 140-143 , June 2006

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