Annals of Diagnostic Pathology
Volume 10, Issue 4 , Pages 193-196 , August 2006

p16, p14, p53, cyclin D1, and steroid hormone receptor expression and human papillomaviruses analysis in primary squamous cell carcinoma of the endometrium

  • Lars-Christian Horn, MD, PhD

      Affiliations

    • Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Department of Perinatal and Gynecologic Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 341 97 150 46; fax: +49 341 97 23 549.
    • ,
  • Christine E. Richter, MD

      Affiliations

    • Department of Perinatal and Gynecologic Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Department of Obstetrics and Gynecology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Jens Einenkel, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Andrea Tannapfel, MD, PhD

      Affiliations

    • Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Uwe-Gerd Liebert, MD, PhD

      Affiliations

    • Institute of Virology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Cornelia Leo, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Leipzig, D-04103 Leipzig, Germany

References 

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  3. Creasman WT, Odicino F, Maisonneuve P, Beller U, Benedet JL, Heintz APM, et al. Carcinoma of the corpus uteri. FIGO annual report on the results of treatment in gynecological cancer, vol. 25. Int J Gynecol Obstet. 2003;83:79–118
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  9. Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Surg Pathol. 1998;153:1741–1748
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  13. Cao QJ, Einstein MH, Anderson PS, Runowicz CD, Balan R, Jones JG. Expression of COX-2, cyclin D1 and p21 in endometrial endometrioid carcinomas. Int J Gynecol Pathol. 2002;21:147–154
  14. Ruhul-Quddus M, Latkovich P, Castellani WJ, Sung JC, Steinhoff MM, Briggs RC, et al. Expression of cyclin D1 in normal, metaplastic, hyperplastic endometrium and endometrioid carcinomas suggesting a role in endometrial carcinogenesis. Arch Pathol Lab Med. 2002;126:459–463
  15. Lax SF. Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virch Arch. 2004;444:213–223
  16. Horn LC, Fischer U, Hänel C, Kuhn H, Raptis G, Bilek K. p53 in surgically treated and pathologically staged cervical cancer: correlation with local tumor progression, but not with lymphatic spread. Pathol Res Pract. 2001;197:605–609
  17. Tannapfel A, Benicke M, Katalinic A, Uhlmann D, Hauss J, Wittekind C. Frequency of p16INK4A alterations and k-ras mutations in intrahepatic cholangiocarcinoma of the liver. Gut. 2000;47:721–727
  18. Bae DS, Cho SB, Kim YJ, Whang JD, Song SY, Park CS, et al. Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical carcinoma of the uterus. Gynecol Oncol. 2001;81:341–347
  19. Goldhirsch A, Wood WC, Gelber RD, Coates AS, Thürlimann B, Senn HJ. Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer. J Clin Oncol. 2003;21:1–9
  20. Horn LC, Edelmann J, Hähnel C, Fischer U, Müller A, Höckel M. Identity testing in cervical carcinoma in case of suspected mix-up. Int J Gynecol Pathol. 2000;19:387–389
  21. Jacobs MV, Snijders PJ, van den Brule AJ, Helmerhorst TJ, Meijer CJ, Walboomers JM. A general primer GP5+/GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings. J Clin Microbiol. 1997;35:791–795
  22. Remmerbach Brinckmann UG, Hemprich A, Chekol M, Kühndel K, Liebert UG. PCR detection of human papillomavirus of the mucosa: comparison between MY09/11 and GP5+/6+ primer sets. J Clin Virol. 2004;30:302–308
  23. Lininger RA, Wistuba I, Gazdar A, Koenig C, Tavassoli FA, Albores-Saavedra J. Human papillomavirus type 16 is detected in transitional cell carcinomas and squamotransitional cell carcinomas of the cervix and endometrium. Cancer. 1998;83:521–527
  24. Czerwenka K, Lu Y, Heuss F, Manavi M, Kubista E. Human papillomavirus detection of endometrioid carcinoma with squamous differentiation of the uterine corpus. Gynecol Oncol. 1996;61:210–214
  25. Kataoka A, Hishida T, Sugiyama T, Hori K, Honda S, Yakushiji M. Squamous cell carcinoma of the endometrium with human papillomavirus type 31 and without tumor suppressor gene p53 mutation. Gynecol Oncol. 1997;65:180–184
  26. Breuer RH, Snijders PJ, Sutedja GT, Sewalt RG, Otte AP, Postmus PE, et al. Expression of the p16(INK4a) gene product, methylation of the p16(INK4a) promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung carcinoma and premalignant endobronchial lesions. Lung Cancer. 2005;48(3):299–306
  27. Semczuk A, Miturski R, Skomra D, Jakowicki JA. Expression of the cell-cycle regulatory proteins (pRb, cyclin D1, p16INK4A and CDK4) in human endometrial cancer: correlation with clinicopathologic features. Arch Gynecol Obstet. 2004;269:104–110
  28. Horn LC, Lax SF, Höckel M, Fischer U, Schmidt D. Precancerous lesions of the endometrium: a review of the molecular pathogenesis and problems in terminology. Geburtsh Frauenheilk. 2001;61:8–14
  29. Im DD, Shah KV, Rosenshein NB. Report of three new cases of squamous carcinoma of the endometrium with emphasis in the HPV status. Gynecol Oncol. 1995;56(3):464–469

PII: S1092-9134(05)00152-8

doi: 10.1016/j.anndiagpath.2005.09.001

Annals of Diagnostic Pathology
Volume 10, Issue 4 , Pages 193-196 , August 2006

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