Annals of Diagnostic Pathology
Volume 10, Issue 5 , Pages 253-256 , October 2006

Juxtatumoral desmoplastic stromal reaction is associated with high tumor cell dissociation in squamous cell carcinomas of the uterine cervix

  • Lars-Cristian Horn, MD, PhD

      Affiliations

    • Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Department of Perinatal and Gynecologic Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Corresponding Author InformationCorresponding author. Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany. Tel.: +49 341 97 150 46; fax: +49 341 97 23 549.
    • ,
  • Christine E. Richter, MD

      Affiliations

    • Department of Perinatal and Gynecologic Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Department of Obstetrics and Gynecology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Bettina Hentschel, MA

      Affiliations

    • Institute of Medical Statistics and Epidemiology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Alexander Schütz, MD

      Affiliations

    • Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Henryk Pilch, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Cornelia Leo, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Michael Höckel, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Leipzig, D-04103 Leipzig, Germany

References 

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  6. Kristensen GB, Abeler VM, Risberg B, Trop C, Bryne M. Tumor size, depth of invasion, and grading of the invasive tumor front are the main prognostic factors in early squamous cell cervical carcinoma. Gynecol Oncol. 1999;74:245–251
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  14. Iacobuzio-Donahue CA, Argani P, Hempen PM, Jones J, Kern SE. The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types. Cancer Res. 2002;62:5351–5357
  15. De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol. 2003;200:429–447
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  17. Wells M, Östör AG, Crum CP, Franceschi S, Tommasino M, Nesland JM, et al. Epithelial tumors of the uterine cervix. In:  Tavassoli FA,  Devilee P editor. Pathology and genetics of tumours of the breast and female genital organs. World Health Organization Classification of Tumours. IARC Press; 2003;p. 259–279
  18. Fox SB, Taylor M, Grondahl-Hansen J, Kakolyris S, Gatter KC, Harris AL. Plasminogen activator inhibitor–1 as a measure of vascular remodelling in breast cancer. J Pathol. 2001;195:236–243
  19. Hartel M, Di Mola FF, Gardini A, Zimmermann A, Di Sebastiano P, Guweidhi A, et al. Desmoplastic reaction influences pancreatic cancer growth behavior. World J Surg. 2004;28:818–825
  20. Shimabukuro K, Ichinose S, Koike R, Kubota T, Yamaguchi M, Miyasaka M, et al. Hepatocyte growth factor/scatter factor is implicated in the mode of stromal invasion of uterine squamous cervical cancer. Gynecol Oncol. 2001;83:205–215
  21. Schutz A, Hartig W, Wobus M, Grosche J, Wittekind Ch, Aust G. Expression of ADAM15 in lung carcinomas. Virchows Arch. 2005;446:421–429
  22. Iacobuzio-Donahue CA, Ryu B, Hruban RH, Kern SE. Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion. Am J Pathol. 2002;160:91–99

PII: S1092-9134(05)00154-1

doi: 10.1016/j.anndiagpath.2005.09.003

Annals of Diagnostic Pathology
Volume 10, Issue 5 , Pages 253-256 , October 2006

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