Annals of Diagnostic Pathology
Volume 10, Issue 4 , Pages 235-238, August 2006

Bronchogenic carcinoma of squamous cells in a young pregnant woman

General Pathology Division, Biological Science Department, Triângulo Mineiro Medical School Uberaba MG 38025-180, Brazil

Abstract 

Lung cancer continues to be the most incident neoplasia in the world and also the most frequent cause of death by cancer, with more than 900000 new cases per year. Women present greater risk of developing bronchogenic carcinoma, possibly because of differences in metabolism of the carcinogens associated with tobacco and also because of hormonal differences because estrogens can promote the appearance of lung cancer, including during pregnancy. We have described the case of a 25-year-old patient who developed squamous cell carcinoma of the lung during her third pregnancy, with a progressive worsening of her general condition and progression until death. We believe that the pregnancy could have contributed to the evolution of the disease, especially because of the increased levels of gestational hormones, particularly the estrogen, because its receptors have an important role in regulating growth and in the differentiation of several tissues facilitating like this, the development of the neoplasia, and complicating its early diagnosis.

Keywords: Bronchogenic carcinoma, Pregnancy, Squamous cells

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 This study was conducted in the General Pathology Division of Triângulo Mineiro Medical School, Uberaba City, Minas Gerais State, Brazil, with grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes), and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) e Fundação de Ensino e Pesquisa de Uberaba (FUNEPU).

PII: S1092-9134(05)00164-4

doi:10.1016/j.anndiagpath.2005.09.014

Annals of Diagnostic Pathology
Volume 10, Issue 4 , Pages 235-238, August 2006