Annals of Diagnostic Pathology
Volume 10, Issue 4 , Pages 205-208 , August 2006

Human telomerase and α-methylacyl-coenzyme A racemase in prostatic carcinoma. A comparative immunohistochemical study

  • Ana Graciela Puebla-Mora, MD

      Affiliations

    • Department of Pathology, Instituto Nacional de Cancerologia, Tlalpan, D.F. 14080, México
    • ,
  • Alfonso Heras, DVM, PhD

      Affiliations

    • BIO SB, Inc, Santa Barbara, CA, USA
    • ,
  • Ana María Cano-Valdez, MD

      Affiliations

    • Department of Pathology, Instituto Nacional de Cancerologia, Tlalpan, D.F. 14080, México
    • ,
  • Hugo Domínguez-Malagón, MD

      Affiliations

    • Department of Pathology, Instituto Nacional de Cancerologia, Tlalpan, D.F. 14080, México
    • Corresponding Author InformationCorresponding author. Tel.: +52 55 5628 0422; fax: +52 55 5628 0422.

References 

  1. Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science. 1995;269:1236–1241
  2. Kumaki F, Kawai T, Hiroi S, et al. Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas. Hum Pathol. 2001;32(2):188–195
  3. Sommerfeld HJ, Meeker AK, Piatyszek MA, Bova GS, Shay JW, Coffey DS. Telomerase activity: a prevalent marker of malignant human prostate tissue. Cancer Res. 1996;56:218–222
  4. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994;266:2011–2015
  5. Shay JW, Wright WE. Telomerase activity in human cancer. Curr Opin Oncol. 1996;8:66–71
  6. Shay JW, Wright W, Werbin H. Defining the molecular mechanism of human cell immortalization (review). Biochim Biophys Acta. 1991;1072:1–7
  7. Counter CM, Avilion AA, Le Feuvre C, et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO. 1992;1(5):1921–1929
  8. Kitagawa Y, Kyo S, Takakura M, et al. Demethylating reagent 5-azacytidine inhibits telomerase activity in human prostate cancer cells through transcriptional repression of hTERT. Clin Cancer Res. 2000;6:2868–2875
  9. Iczkowski KA, Pantazis CG, McGregor DH, Wu Y, Tawfik OW. Telomerase reverse transcriptase subunit immunoreactivity. A marker for high-grade prostate carcinoma. Cancer. 2002;95(12):2487–2493
  10. Counter CM, Hirte HW, Baccheti S, Harley CB. Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci U S A. 1994;91:2900–2904
  11. Nilsson P, Mehle C, Roos R, Roos G. Telomerase activity in vivo in human malignant hematopoietic cells. Oncogene. 1994;9:3043–3048
  12. Etherdge K, Banik S, et al. The nucleolar localization domain of the catalytic subunit of human telomerase. J Biol Chem. 2002;277(27):
  13. Heras A, Ghirardi G, et al. Telomerase and Ki67 immunohistochemistry as diagnostic markers form cervical cancer. Mod Pathol. 2003;16(1):192A
  14. Beach A, Gown M, de Peralta-Venturina MN, et al. P504s Immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies. Am J Surg Pathol. 2002;26(12):1588–1596
  15. Jiang Z, Wu CH, Woda B. P504s/α-methylacyl-CoA racemase. A useful marker for the diagnosis of small foci of prostatic carcinoma on needle biopsy. Am J Surg Pathol. 2002;26(9):1169–1174
  16. Zhang W, Kapusta L, Slingerland J, Klotz L. Telomerase activity in prostate cancer, prostatic intraepithelial neoplasia, and benign prostatic epithelium. Cancer Res. 1998;58:619–621

PII: S1092-9134(05)00172-3

doi: 10.1016/j.anndiagpath.2005.09.021

Annals of Diagnostic Pathology
Volume 10, Issue 4 , Pages 205-208 , August 2006

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