Annals of Diagnostic Pathology
Volume 10, Issue 6 , Pages 367-370 , December 2006

Benign hybrid perineurioma-schwannoma in the colon. A case report

  • Patrick Emanuel, MD

      Affiliations

    • Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    • ,
  • David S. Pertsemlidis, MD

      Affiliations

    • Department of Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    • ,
  • Ronald Gordon, PhD

      Affiliations

    • Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    • ,
  • Ruliang Xu, MD, PhD

      Affiliations

    • Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 241 5307; fax: +1 212 828 4188.

References 

  1. Tsang WY, Chan JK, Chow LT, Tse CC. Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. Am J Surg Pathol. 1992;16:756–763
  2. Hornick JL, Fletcher CD. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol. 2005;29:845–858
  3. Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins RB. Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22. Am J Clin Pathol. 1995;103:696–704
  4. Algros MP, Bernardini S, Gebhard S, et al. Extra neural perineurioma: an unusal renal tumor. Ann Pathol. 2002;22:476–479
  5. Kahn DG, Duckett T, Bhuta SM. Perineurioma of the kidney. Report of a case with histologic, immunohistochemical, and ultrastructural studies. Arch Pathol Lab Med. 1993;117:654–657
  6. Agaimy A, Wuensch PH. Perineurioma of the stomach. A rare spindle cell neoplasm that should be distinguished from gastrointestinal stromal tumor. Pathol Res Pract. 2005;201:463–467
  7. Hornick JL, Fletcher CD. Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol. 2005;29:859–865
  8. Zamecnik M, Michal M. Perineurial cell differentiation in neurofibromas. Report of eight cases including a case with composite perineurioma-neurofibroma features. Pathol Res Pract. 2001;197:537–544
  9. Feany MB, Anthony DC, Fletcher CD. Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge. Histopathology. 1998;32:405–410
  10. Kazakov DV, Pitha J, Sima R, et al. Hybrid peripheral nerve sheath tumors: schwannoma-perineurioma and neurofibroma-perineurioma. A report of three cases in extradigital locations. Ann Diagn Pathol. 2005;9:16–23
  11. Folpe AL, Billings SD, McKenney JK, Walsh SV, Nusrat A, Weiss SW. Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimics. Am J Surg Pathol. 2002;26:1620–1626
  12. Miettinen M, Shekitka KM, Sobin LH. Schwannomas in the colon and rectum: a clinicopathologic and immunohistochemical study of 20 cases. Am J Surg Pathol. 2001;25:846–855
  13. Prevot S, Bienvenu L, Vaillant JC, de Saint-Maur PP. Benign schwannoma of the digestive tract: a clinicopathologic and immunohistochemical study of five cases, including a case of esophageal tumor. Am J Surg Pathol. 1999;23:431–436
  14. Huang HY, Park N, Erlandson RA, Antonescu CR. Immunohistochemical and ultrastructural comparative study of external lamina structure in 31 cases of cellular, classical, and melanotic schwannomas. Appl Immunohistochem Mol Morphol. 2004;12:50–58
  15. Miettinen M, Lasota J, Sobin LH. Gastrointestinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases with long-term follow-up and review of the literature. Am J Surg Pathol. 2005;29:1373–1381
  16. Pantanowitz L, Antonioli DA, Pinkus GS, Shahsafaei A, Odze RD. Inflammatory fibroid polyps of the gastrointestinal tract: evidence for a dendritic cell origin. Am J Surg Pathol. 2004;28:107–114
  17. Erlandson RA. The enigmatic perineurial cell and its participation in tumors and in tumorlike entities. Ultrastruct Pathol. 1991;15:335–351
  18. Kharbanda K, Dinda AK, Sarkar C, Karak AK, Mathur M, Roy S. Cell culture studies on human nerve sheath tumors. Pathology. 1994;26:29–32

PII: S1092-9134(05)00186-3

doi: 10.1016/j.anndiagpath.2005.11.004

Annals of Diagnostic Pathology
Volume 10, Issue 6 , Pages 367-370 , December 2006

Article Tools

* Image Usage & Resolution