Annals of Diagnostic Pathology
Volume 10, Issue 3 , Pages 133-139 , June 2006

Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 cases

  • Ondrej Hes, MD, PhD

      Affiliations

    • Department of Special Diagnostics SPAU, University Hospital Plzen, 30460 Czech Republic
    • ,
  • Matteo Brunelli, MD

      Affiliations

    • Anatomia patologica, Universita di Verona, 37134 Italy
    • ,
  • Michal Michal, MD

      Affiliations

    • Department of Special Diagnostics SPAU, University Hospital Plzen, 30460 Czech Republic
    • Corresponding Author InformationCorresponding author. Laborator Spec. Diagnostiky SPAU, University Hospital, 304 60 Plzen, Czech Republic. Tel.: +42 0 603886633, +42 0 377104630; fax: +42 0 377104650.
    • ,
  • Paolo Cossu Rocca, MD

      Affiliations

    • Anatomia patologica, Universita di Sassari, 07100 Italy
    • ,
  • Milan Hora, MD, PhD

      Affiliations

    • Department of Urology, University Hospital Plzen, 30460 Czech Republic
    • ,
  • Marco Chilosi, MD

      Affiliations

    • Anatomia patologica, Universita di Verona, 37134 Italy
    • ,
  • Michaela Mina, MD

      Affiliations

    • Anatomia patologica, Universita di Verona, 37134 Italy
    • ,
  • Ludmila Boudova, MD, PhD

      Affiliations

    • Department of Special Diagnostics SPAU, University Hospital Plzen, 30460 Czech Republic
    • ,
  • Fabio Menestrina, MD

      Affiliations

    • Anatomia patologica, Universita di Verona, 37134 Italy
    • ,
  • Guido Martignoni, MD

      Affiliations

    • Anatomia patologica, Universita di Verona, 37134 Italy
    • Anatomia patologica, Universita di Sassari, 07100 Italy

References 

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  16. Gunawan B, von Heydebreck A, Fritsch T. Cytogenetic and morphologic typing of 58 papillary renal cell carcinomas: evidence for a cytogenetic evolution of type 2 from type 1 tumors. Cancer Res. 2003;63:6200–6205
  17. Brunelli M, Eble JN, Zhang S, et al. Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, 10 and 17, and this pattern of genetic abnormalities is not present in renal oncocytoma. Mod Pathol. 2005;18:161–169
  18. Kovacs G, Fuzesi L, Emanual A, et al. Cytogenetics of papillary renal cell tumors. Genes Chromosomes Cancer. 1991;3:249–255
  19. Higgins JP, Wang L, Kambham N, et al. Gene expression in the normal adult human kidney assessed by complementary DNA microarray. Mol Biol Cell. 2004;15:649–656
  20. Tretiakova MS, Sahoo S, Takahashi M, et al. Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. Am J Surg Pathol. 2004;28:69–76
  21. Martignoni G, Pea M, Brunelli M, et al. CD10 is expressed in a subset of chromophobe renal cell carcinomas. Mod Pathol. 2004;17:1455–1463
  22. Avery AK, Beckstead J, Renshaw AA. Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol. 2000;24:203–210
  23. Lindgren V, Paner GP, Omeroglu A, et al. Cytogenetic analysis of a series of 13 renal oncocytomas. J Urol. 2004;171:602–604
  24. Martignoni G, Pea M, Bonetti F, et al. Oncocytoma-like angiomyolipoma. A clinicopathologic and immunohistochemical study of 2 cases. Arch Pathol Lab Med. 2002;126:610–612
  25. Amin MB, Crotty TB, Tickoo SK, et al. Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am J Surg Pathol. 1997;21:1–12
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  27. Martignoni G, Pea M, Chilosi M, et al. Parvalbumin is constantly expressed in chromophobe renal carcinoma. Mod Pathol. 2001;14:760–767

☆ This study was supported in part by Fondazione Cassa di Risparmio di Verona (bando 2001), Banco di Sardegna (2003), AIRC, Milan, MIUR, and Diagnostica Molecolare in Oncologia (2003).

PII: S1092-9134(05)00209-1

doi: 10.1016/j.anndiagpath.2005.12.002

Annals of Diagnostic Pathology
Volume 10, Issue 3 , Pages 133-139 , June 2006

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