Annals of Diagnostic Pathology
Volume 11, Issue 1 , Pages 61-63 , February 2007

Hepatocellular carcinoma, syncytial giant cell: a novel variant in children: a case report

  • A. Atra, MD, MRCPath

      Affiliations

    • Department of Oncology, King Abdulaziz Medical City–Jeddah, PO Box 9515, Jeddah 21423, Kingdom of Saudi Arabia
    • Corresponding Author InformationCorresponding author. Fax: +966 699 2 6247444.
    • ,
  • R. Al-Asiri, MD

      Affiliations

    • Department of Pediatrics, Riyadh Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia
    • ,
  • S. Wali, MD

      Affiliations

    • Department of Pediatrics, Riyadh Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia
    • ,
  • H. Al-Husseini, MD

      Affiliations

    • Department of Histopathology, Riyadh Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia
    • ,
  • A Al-Bassas, MD

      Affiliations

    • Department of Surgery, Riyadh Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia
    • ,
  • A. Zimmermann, MD

      Affiliations

    • Institute of Pathology of the University of Bern, Bern, Switzerland (Coordinator of the SIOPEL-3 Liver Tumor Studies)

References 

  1. Moore SW, Hesseling PB, Wesswls G, et al. Hepatocellular carcinoma in children. Pediatr Surg Int. 1997;12:266–270
  2. Bellani FF, Massimino M. Liver tumors in childhood: epidemiology and clinics. J Surg Oncol Suppl. 1993;3:119–121
  3. Leuschner I, Harms D, Schmidt D. The association of hepatocellular carcinoma in childhood with hepatitis B infection. Cancer. 1998;62:2363–2369
  4. Pritchard J, Brown J, Shafford E, et al. Cisplatin, doxorubicin and delayed surgery for childhood hepatoblastoma: a successful approach. Results of the first prospective study of the International Society of Pediatric Oncology (SIOP)—SIOPEL 1. J Clin Oncol. 2000;18:3819–3828
  5. Kirk JM, Brain CE, Carson DJ, et al. Cushing's syndrome caused by nodular adrenal hyperplasia in children with McCune-Albright syndrome. J Pediatr. 1999;134:789–792
  6. Albers N, Jorgens S, Deiss D, et al. McCune-Albright syndrome—the German experience. J Pediatr Endocrinol Metab. 2002;15(Suppl 3):897–901
  7. Davies JH, Barton JS, Gredory JW, et al. Infantile McCune-Albright syndrome. Pediatr Dermatol. 2001;18:504–506
  8. Kuwano H, Sonoda T, Hashimoto H, et al. Hepatocellular carcinoma with osteoclast-like giant cells. Cancer. 1984;54:837–842
  9. Hood EL, Bauer TW, Leibel SA, et al. Hepatic giant cell carcinoma: an ultra structural and immunohistochemical study. Am J Clin Pathol. 1990;93:111–116
  10. Sasaki A, Yokoyama S, Nakayama I, et al. Sarcomatoid hepatocellular carcinoma with osteoblast-like giant cells: case report and immunohistochemical observations. Pathol Int. 1997;47:318–324
  11. Rosai J. Liver cell carcinoma with osteoclast-like giant cells: nonepitheliogenic giant cells in diverse malignancies. Hepatology. 1990;12:782–783
  12. Koukoulis G, Mieli-Vergani G, Portmann B. Infantile liver giant cells: immnuohistochemical study of their proliferative state and possible mechanisms of formation. Pediatr Dev Pathol. 1999;2:353–359

PII: S1092-9134(05)00212-1

doi: 10.1016/j.anndiagpath.2005.12.005

Annals of Diagnostic Pathology
Volume 11, Issue 1 , Pages 61-63 , February 2007

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