Annals of Diagnostic Pathology
Volume 10, Issue 5 , Pages 269-273 , October 2006

Immunohistochemical detection of p63 in testicular germ cell neoplasia

References 

  1. Yang A, Kaghad M, Caput F, McKeon D. On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet. 2002;18:90–95
  2. Nylander K, Vojtesek B, Nenutil R, et al. Differential expression of p63 isoforms in normal tissues and neoplastic cells. J Pathol. 2002;198(4):417–427
  3. King KE, Ponnamperuma RM, Yamashita T, et al. DeltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. Oncogene. 2003;22:3635–3644
  4. Yang A, Schweitzer R, Sun D, et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999;398:714–718
  5. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 1999;398:708–713
  6. Di Como CJ, Urist MJ, Babayan I, et al. p63 Expression profiles in human normal and tumor tissues. Clin Cancer Res. 2002;8:494–501
  7. Signoretti S, Waltregny D, Dilks J, et al. p63 is a prostate basal cell marker and is required for prostate development. Am J Surg Pathol. 2000;157:1769–1775
  8. Barbareschi M, Pecciarini L, Cangi Mg, et al. p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast. Am J Surg Pathol. 2001;25:1054–1060
  9. Wang BY, Gil J, Kaufman D, Gan L, Kohtz DS, Burstein DE. p63 in pulmonary epithelium, pulmonary squamous neoplasms and other pulmonary tumors. Hum Pathol. 2002;33:921–926
  10. Nylander K, Coates PJ, Hall PA. Characterization of the expression pattern of p63 alpha and delta Np63alpha in benign and malignant oral epithelial lesions. Int J Cancer. 2000;87:368–372
  11. Quade BJ, Yang A, Wang Y, et al. Expression of the p53 homologue p63 in early cervical neoplasia. Gynecol Oncol. 2001;80:24–29
  12. Wang TY, Chen BF, Yang YC, et al. Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases. Hum Pathol. 2001;32:479–486
  13. Glickman JN, Yang A, Shahsafaei A, McKeon F, Odze RD. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Hum Pathol. 2001;32:1157–1165
  14. Park BJ, Lee SJ, Kim JI, et al. Frequent alteration of p63 expression in human primary bladder carcinomas. Cancer Res. 2000;60:3370–3374
  15. O'Connell JT, Mutter GL, Cviko A, et al. Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63. Gynecol Oncol. 2001;80:30–36
  16. Unger P, Ewart M, Wang BY, Gan L, Kohtz DS, Burstein DE. Expression of p63 in papillary thyroid carcinoma and in Hashimoto's thyroiditis: a pathobiologic link?. Hum Pathol. 2003;34:764–769
  17. Chilosi M, Zamo A, Brighenti A, et al. Constitutive expression of DeltaN-p63alpha isoform in human thymus and thymic epithelial tumours. Virchows Arch. 2003;443:175–183
  18. Emanuel P, Wang B, Wu M, Burstein DE. p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol. 2005;18(5):645–650
  19. Nakamuta N, Kobayashi S. Developmental expression of p63 in the mouse testis. J Vet Med Sci. 2004;66(6):681–687
  20. Nakamuta N, Kobayashi S. Expression of p63 in the mouse primordial germ cells. J Vet Med Sci. 2004;66(11):1365–1370
  21. Shih IM, Kurman RJ. p63 Expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. Am J Surg Pathol. 2004;28(9):1177–1183
  22. Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998;2:305–316
  23. Duncan DA, Mazur MT. Trophoblastic tumors: ultrastructural comparison of choriocarcinoma and placental-site trophoblastic tumor. Hum Pathol. 1989;20(4):370–381
  24. Reis-Filho JS, Preto A, Soares P, Ricardo S, Cameselle-Teijeiro J, Sobrinho-Simoes M. p63 Expression in solid cell nests of the thyroid: further evidence for a stem cell origin. Mod Pathol. 2003;16(1):43–48
  25. Unger P, Ewart M, Wang BY, Gan L, Kohtz DS, Burstein DE. Expression of p63 in papillary thyroid carcinoma and in Hashimoto's thyroiditis: a pathobiologic link?. HumPathol. 2003;34(8):764–769
  26. Burstein DE, Nagi C, Wang BY, Unger P. Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and Hashimoto's thyroiditis: a stem cell hypothesis of papillary carcinoma oncogenesis. Hum Pathol. 2004;35(4):465–473
  27. Jones TD, Ulbright TM, Eble JN, Baldridge LA, Cheng L. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. Am J Surg Pathol. 2004;28(7):935–940
  28. In:  Craigmyle MBL,  Presley R editor. Embryology. 2nd ed.. London: B. Tindall Co; 1975;p. 223
  29. Elsasser E. Tumors of the epididymis. Recent Results Cancer Res. 1977;60:163–175

PII: S1092-9134(06)00010-4

doi: 10.1016/j.anndiagpath.2006.02.005

Annals of Diagnostic Pathology
Volume 10, Issue 5 , Pages 269-273 , October 2006

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