Annals of Diagnostic Pathology
Volume 10, Issue 6 , Pages 327-332 , December 2006

The status of cyclooxygenase-2 expression in ductal carcinoma in situ lesions and invasive breast cancer correlates to cyclooxygenase-2 expression in normal breast tissue

  • Cornelia Leo, MD

      Affiliations

    • Department of Gynecology, Leipzig University, 04103 Leipzig, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 341 97 23400; fax: +49 341 97 23409.
    • ,
  • Stefanie Faber, MD

      Affiliations

    • Department of Gynecology, Leipzig University, 04103 Leipzig, Germany
    • ,
  • Bettina Hentschel, MSc

      Affiliations

    • Institute for Medical Informatics, Statistics and Epidemiology,Leipzig University, 04107 Leipzig, Germany
    • ,
  • Michael Höckel, MD, PhD

      Affiliations

    • Department of Gynecology, Leipzig University, 04103 Leipzig, Germany
    • ,
  • Lars-Christian Horn, MD

      Affiliations

    • Division of Gynecologic Pathology, Department of Pathology, Leipzig University, 04103 Leipzig, Germany

References 

  1. Soslow RA, Dannenberg AJ, Rush D, et al. COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer. 2000;89:2637–2645
  2. Ristimaki A, Honkanen N, Jankala H, et al. Expression of cyclooxygenase-2 in human gastric carcinoma. Cancer Res. 1997;57:1276–1280
  3. Ferrandina G, Lauriola L, Distefano MG, et al. Increased cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients. J Clin Oncol. 2002;20:973–981
  4. Ristimaki A, Sivula A, Lundin J, et al. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res. 2002;62:632–635
  5. Sano H, Kawahito Y, Wilder RL, et al. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. 1995;55:3785–3789
  6. Hla T, Bishop-Bailey D, Liu CH, et al. Cyclooxygenase-1 and -2 isoenzymes. Int J Biochem Cell Biol. 1999;31:551–557
  7. Schmedtje JF, Ji YS, Liu WL, et al. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem. 1997;272:601–608
  8. Singh B, Lucci A. Role of cyclooxygenase-2 in breast cancer. J Surg Res. 2002;108:173–179
  9. Amir M, Agarwal HK. Role of COX-2 selective inhibitors for prevention and treatment of cancer. Pharmazie. 2005;60:563–570
  10. Sheng H, Shao J, Morrow JD, et al. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res. 1998;58:362–366
  11. Lin MT, Lee RC, Yang PC, et al. Cyclooxygenase-2 inducing Mcl-1–dependent survival mechanism in human lung adenocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2001;276:48997–49002[Electronic publication, 42001 Oct 48993]
  12. Gately S, Li WW. Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy. Semin Oncol. 2004;31:2–11
  13. Singh B, Berry JA, Shoher A, et al. COX-2 overexpression increases motility and invasion of breast cancer cells. Int J Oncol. 2005;26:1393–1399
  14. Half E, Tang XM, Gwyn K, et al. Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. Cancer Res. 2002;62:1676–1681
  15. Boland GP, Butt IS, Prasad R, et al. COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. Br J Cancer. 2004;90:423–429
  16. Shim V, Gauthier ML, Sudilovsky D, et al. Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. Cancer Res. 2003;63:2347–2350
  17. Denkert C, Winzer KJ, Muller BM, et al. Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. Cancer. 2003;97:2978–2987
  18. Kelly LM, Hill AD, Kennedy S, et al. Lack of prognostic effect of Cox-2 expression in primary breast cancer on short-term follow-up. Eur J Surg Oncol. 2003;29:707–710
  19. Ranger GS, Jewell A, Thomas V, et al. Elevated expression of cyclooxygenase-2 in breast cancer and ductal carcinoma in situ has no correlation with established prognostic markers. J Surg Oncol. 2004;88:100–103
  20. Wulfing P, Diallo R, Muller C, et al. Analysis of cyclooxygenase-2 expression in human breast cancer: high throughput tissue microarray analysis. J Cancer Res Clin Oncol. 2003;129:375–382[Electronic publication, 2003 Jul 2015]
  21. Harris RE, Namboodiri KK, Farrar WB. Nonsteroidal antiinflammatory drugs and breast cancer. Epidemiology. 1996;7:203–205
  22. Schreinemachers DM, Everson RB. Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology. 1994;5:138–146
  23. Sharpe CR, Collet JP, McNutt M, et al. Nested case-control study of the effects of non-steroidal anti-inflammatory drugs on breast cancer risk and stage. Br J Cancer. 2000;83:112–120
  24. Watanabe O, Shimizu T, Imamura H, et al. Expression of cyclooxygenase-2 in malignant and benign breast tumors. Anticancer Res. 2003;23:3215–3221
  25. Costa C, Soares R, Reis-Filho JS, et al. Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. J Clin Pathol. 2002;55:429–434
  26. Larson PS, de las Morenas A, Cupples LA, et al. Genetically abnormal clones in histologically normal breast tissue. Am J Pathol. 1998;152:1591–1598
  27. Braakhuis BJ, Tabor MP, Kummer JA, et al. A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res. 2003;63:1727–1730
  28. Howe LR, Chang SH, Tolle KC, et al. HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Cancer Res. 2005;65:10113–10119
  29. Liu CH, Chang SH, Narko K, et al. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J Biol Chem. 2001;276:18563–18569[Electronic publication, 12001 Mar 18567]
  30. Rao CV, Reddy BS. NSAIDs and chemoprevention. Curr Cancer Drug Targets. 2004;4:29–42
  31. Wang D, Dubois RN. Cyclooxygenase-2: a potential target in breast cancer. Semin Oncol. 2004;31:64–73

PII: S1092-9134(06)00029-3

doi: 10.1016/j.anndiagpath.2006.03.002

Annals of Diagnostic Pathology
Volume 10, Issue 6 , Pages 327-332 , December 2006

Article Tools

* Image Usage & Resolution