Annals of Diagnostic Pathology
Volume 10, Issue 6 , Pages 333-338 , December 2006

Flat elevated lesions of the colon and rectum: a spectrum of neoplastic and nonneoplastic entities

  • Gabriela Gualco, MD

      Affiliations

    • Department of Pathology, Armed Forces Hospital, Montevideo 10000, Uruguay
    • ,
  • Nelson Reissenweber, MD

      Affiliations

    • Department of Pathology, Clinical Hospital, Montevideo 10000, Uruguay
    • Deceased
    • ,
  • Ivanah Cliché, MD

      Affiliations

    • Department of Gastroenterology, Armed Forces and Clinical Hospital, Montevideo 10000, Uruguay
    • ,
  • Carlos E. Bacchi, MD

      Affiliations

    • Consultoria Patologia, Botucatu, SP 18602-010, Brazil
    • Department of Pathology, Albert Einstein Jewish Hospital, Sāo Paulo 18602-010, Brazil
    • Corresponding Author InformationCorresponding author. Consultoria Patologia, Rua Major Leônidas Cardoso 739, Botucatu, SP 18602-010, Brazil. Tel.: +55 14 3815 5989; fax: +55 14 3815 5989.

References 

  1. Muto T, Kamiya J, et al. Small “flat adenoma” of the large bowel with special reference to its clinicopathologic features. Dis Colon Rectum. 1985;28:847–851
  2. Watanabe T, Sawada T, Kubota Y, et al. Malignant potential in flat elevations. Dis Colon Rectum. 1993;36:584–653
  3. Wolber RA, Owen DA. Flat adenomas of the colon. Hum Pathol. 1991;22:70–74
  4. Muto T, Bussy HJ, Morson BC. The evolution of the colon and rectum. Cancer. 1975;36:2251–2270
  5. Muto T, Kamiya J, Sawara T, Morioka Y. Morphogenesis of human colonic cancer. Dis Colon Rectum. 1991;26:696–699
  6. Adachi M, Muto T, Okinaga K, Morioka Y. Clinicopathologic features of the flat adenomas. Dis Colon Rectum. 1991;34:981–986
  7. Reissenweber N, Gualco G, Ardao G, et al. The interrelationship between tubular and papillary sectors of tubulo-villous adenomas: comparative morphometric analysis and evaluation of cell proliferation. Hum Pathol. 1998;29:431–437
  8. Eide TJ. A morphometrical analysis of dysplasia in small adenoma of de large intestine. Virchows Arch A Pathol Anat Histopathol. 1986;410:119–124
  9. Kuramoto S, Ihara O, Sakai S, et al. Depressed adenoma in the large intestine. Endoscopic features. Dis Colon Rectum. 1990;33:108–112
  10. Kudo S. Endoscopic mucosal resection of flat and depressed types of early colorectal cancer. Endoscopy. 1993;25:455–461
  11. Matsumoto T, Linda M, Kuwano IM, et al. Minute non-polypoid adenomas of the colon detected by colonoscopy, correlation between endoscopic and histological findings. Gastrointest Endos. 1992;38:645–650
  12. Mittoka H, Fujimori T, Maeda S, Nagasako K. Minute flat depressed neoplastic lesions of de colon detected by contrast chromoscopy using and indigo carmin capsule. Gastrointest Endosc. 1995;41:453–459
  13. Wada R, Matsukuma S, Aloe H, et al. Histopathological studies of superficial type–early colorectal carcinoma. Cancer. 1996;77:44–50
  14. Owen DA. Flat adenoma, flat carcinoma and novo carcinoma of the colon. Cancer. 1996;77:3–6
  15. Hurlstone D, Cross S, Drew K, et al. An evaluation of colorectal endoscopic mucosal resection using high magnification chromoscopic colonoscopy: a prospective study of 1000 colonoscopies. Endoscopy. 2004;36:491–498
  16. Samowitz WS, Burt RL. The nonspecificity of histological findings reported on flat adenomas. Hum Pathol. 1995;26:571–573
  17. Kubota O, Kino I. Minute adenomas of the depressed type in familial adenomatous polyposis of the colon. Cancer. 1993;72:1159–1164
  18. Kuramoto S, Oohara T. Flat early cancers of the large intestine. Cancer. 1989;64:950–955
  19. Kuramoto S, Oohara T. Minute cancer arising de novo in the human large intestine cancer. Cancer. 1988;829–835
  20. Jaramillo E, Wantanabe M, Slezak P, Rubio C. Flat neoplastic lesions of the colon and rectum detected by high-resolution video endoscopy and chromoscopy. Gastrointest Endosc. 1995;42:114–122
  21. Pickhardt P, Nugent P, Choi R, Schindler W. Flat colorectal lesions in asymptomatic adults: implications for screening with CT virtual colonoscopy. AJR Am J Roentgenol. 2004;183:1343–1347
  22. Lanspa SJ, Rouse MD, Smyrsk T, et al. Epidemiologic characteristics of the flat adenoma of Muto. A Prospective study. Dis Colon Rectum. 1992;35:543–546
  23. Sato T, Konishi F, Togashi K, Ozawa A, Kanzawa K. Prospective observation of small “flat” tumors in the colon through colonoscopy. Dis Colon Rectum. 1999;42:1457–1463
  24. Rubio C, Shetye J. Flat adenoma adenocarcinoma sequence in the colon of rates. Dis Colon Rectum. 1994;37:1300–1306
  25. Crawford B, Stromeyer W. Small nonpolypoid carcinoma of the large intestine. Cancer. 1983;51:1760–1763
  26. Hunt D, Cherian M. Endoscopic diagnosis of small flat carcinoma of the colon. Report of these cases. Dis Colon Rectum. 1990;33:143–147
  27. Nasir A, Boulware D, Kaise H, et al. Flat and polypoid adenocarcinomas of the colorectum: a comparative histomorphologic analysis of 47 cases. Hum Pathol. 2004;35:604–611

☆ This study was partially supported by Grant No. 27, “Commission Honoraria de Lucha Contra el Cancer,” Montevideo, Uruguay.

PII: S1092-9134(06)00030-X

doi: 10.1016/j.anndiagpath.2006.03.003

Annals of Diagnostic Pathology
Volume 10, Issue 6 , Pages 333-338 , December 2006

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