Annals of Diagnostic Pathology
Volume 10, Issue 5 , Pages 279-282, October 2006

Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma

  • Tilman Rau, MD

      Affiliations

    • Department of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, D-91054 Erlangen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 9131 85 25782; fax: +49 9131 85 25785.
    • ,
  • Stephan Soeder, MD

      Affiliations

    • Department of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, D-91054 Erlangen, Germany
    • ,
  • Alexander Olk, MD

      Affiliations

    • Department of Surgery, Friedrich-Alexander University of Erlangen-Nuremberg, D-91054 Erlangen, Germany
    • ,
  • Thomas Aigner, MD, PhD

      Affiliations

    • Department of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, D-91054 Erlangen, Germany

Abstract 

Lipomas are very common benign soft tissue neoplasms. They are usually slow-growing and may occur anywhere in the body. Mature cartilage and bone arising in a lipoma is a rare event and is mostly associated with a parosteal localization of the neoplasm.

We describe a new case of osteochondrolipoma showing not only major adipocytic differentiation but also areas of fibrocytic and cartilaginous cell differentiation and bone formation (both endochondral and membranous). The occurrence of at least 4 distinct directions of mesenchymal cell differentiation within a benign neoplasia underlines the concept of multilineage differentiation of pluripotent mesenchymal stem cells. Such a multidirectional potential was recently well established in vitro in stem cells present in adult adipocytic tissue.

Keywords: Parosteal lipoma, Multilineage differentiation, Chondrolipoma, Osteolipoma, Mesenchymoma

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1092-9134(06)00036-0

doi:10.1016/j.anndiagpath.2006.03.009

Annals of Diagnostic Pathology
Volume 10, Issue 5 , Pages 279-282, October 2006

Article Tools

* Image Usage & Resolution