Annals of Diagnostic Pathology
Volume 11, Issue 1 , Pages 39-45 , February 2007

Clinicopathologic study of 275 cases of gastrointestinal stromal tumors: the experience at 3 large medical centers in Mexico

  • Isabel Alvarado-Cabrero, MD

      Affiliations

    • Department of Pathology, Mexican Oncology Hospital, Federal District Mexico, IMSS 06700, Mexico
    • Corresponding Author InformationCorresponding author.
    • ,
  • Gonzálo Vázquez, MD

      Affiliations

    • Department of Pathology, UMAE, Guadalajara, Jalisco, IMSS 06700, Mexico
    • ,
  • Francisca I. Sierra Santiesteban, MD

      Affiliations

    • Department of Pathology, Mexican Oncology Hospital, Federal District Mexico, IMSS 06700, Mexico
    • ,
  • Dulce Ma. Hernández-Hernández, MD

      Affiliations

    • Department of Pathology, Mexican Oncology Hospital, Federal District Mexico, IMSS 06700, Mexico
    • ,
  • Angel Zavala Pompa, MD

      Affiliations

    • Department of Pathology, Hospital No 25, Monterrey Nuevo Leon, IMSS 06700, Mexico

References 

  1. Miettinen M, Lasota J. Gastrointestinal stromal tumors—definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch. 2001;438:1–12
  2. Nick L, Nickolas J. Gastrointestinal stromal tumors: new progress, new questions. Curr Opin Gastroenterol. 2004;20:482–487
  3. Miettinen M, Sarlomo-Rikala M, Lasota J. Gastrointestinal stromal tumors: recent advances in understanding of their biology. Hum Pathol. 1999;30:1213–1220
  4. Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol. 1998;152:1259–1269
  5. Torihashi S, Horisawa M, Watanabe Y. C-Kit immunoreactive interstitial cells in the human gastrointestinal tract. J Auton Nerv Syst. 1999;75:38–50
  6. Hirota S, Isozaki K, Moriyama Y, et al. Gain of function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279:577–580
  7. Lux ML, Rubin BP, Biase TL, et al. Kit extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol. 2000;156:791–795
  8. Sarlomo-Rikala M, Kovatich AJ, Barusevicius A, et al. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol. 1998;11:728–734
  9. Demetri GD. OncoloGIST, BioloGIST, RadioloGIST: the big impact on the field of oncology of a molecularly-targeted therapy designed to treat a rare disease. Eur J Cancer. 2003;39:1976–1977
  10. De Matteo RP, Lewis JJ, Leung D, et al. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000;231:51–58
  11. Pidhorecky I, Cheney RT, Kraybill WG, et al. Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management. Ann Surg Oncol. 2000;7:705–712
  12. Pierie JP, Choudry U, Muzikansky A, et al. The effect of surgery and grade on outcome of gastrointestinal stromal tumors. Arch Surg. 2001;136:383–389
  13. Orosz Z, Tornoczky T, Sapi Z. Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases. Pathol Oncol Res. 2005;11:11–21
  14. Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002;33:459–465
  15. Erlandson R, Klimstra D, Woodruff J. Subclassification of gastrointestinal stromal tumors based on evaluation by electron microscopy and immunohistochemistry. Ultrastruct Pathol. 1996;20:373–393
  16. Herrera G, Cerezo L, Jones J, Sack J, Grizzle W, Pollack W, et al. Gastrointestinal autonomic nerve tumors: “plexosarcomas”. Arch Pathol Lab Med. 1989;113:846–853
  17. Herrera G, Demoraes H, Grizzle W, Han S. Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma): light and electron microscopic study confirming the origin of the neoplasm. Dig Dis Sci. 1984;29:275–284
  18. Prakash S, Sarran L, Socci N, De Matteo R, Eisenstat J, Greco A, et al. Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature. J Pediatr Hematol Oncol. 2005;27:179–187
  19. Miettinen M, Lasota J, Sobin L. Gastrointestinal stromal tumors of the stomach in children and young adults. Am J Surg Pathol. 2005;29:1373–1381
  20. Takazawa Y, Sakurai S, Sakuma Y, Ikeda T, Yamaguchi J, Hashizume Y, et al. Gastrointestinal stromal tumors of neurofibromatosis type I (von Recklinghausen's disease). Am J Surg Pathol. 2005;29:755–763
  21. Yamamoto H, Oda Y, Kawaguchi K, Nakamura N, Takahira T, Tamiya S, et al. c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue). Am J Surg Pathol. 2004;28:479–488
  22. Demetri G, Benjamin R, Blanke CD, et al. NCCN Task Force Report: optimal managements of patients with gastrointestinal stromal tumor (GIST)—expansion and update of NCCN clinical practice guidelines. JNCCN. 2004;2(Suppl 1):S1–S26
  23. Miettinen M, Sobin L, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathological, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol. 2005;29:52–68
  24. Yantiss RK, Spiro IJ, Compton CC, Rosenberg AE. GIST versus intraabdominal fibromatosis of the bowel wall: a clinically important differential diagnosis. Am J Surg Pathol. 2000;24:947–957
  25. Miettinen M, El-Rifai W, Sobin LH, Lasota J. Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol. 2002;33:478–483
  26. Sarlomo-Rikala M, Kovatich AJ, Barusevicius A, Miettinen M. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol. 1998;11:728–734
  27. Ma CK, Amin MB, Kintanar E, Linden MD, Zarbo RJ. Immunohistologic characterization of gastrointestinal stromal tumors: a study of 82 cases compared with 11 cases of leiomyomas. Mod Pathol. 1993;6:139–144

PII: S1092-9134(06)00044-X

doi: 10.1016/j.anndiagpath.2006.03.014

Annals of Diagnostic Pathology
Volume 11, Issue 1 , Pages 39-45 , February 2007

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