Annals of Diagnostic Pathology
Volume 10, Issue 3 , Pages 169-192 , June 2006

Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment

References 

  1. Anner RM, Drewinko B. Frequency and significance of bone marrow involvement by metastatic solid tumors. Cancer. 1977;39:1337–1344
  2. Miric A, Banks M, Allen D, et al. Cortical metastatic lesions of the appendicular skeleton from tumors of known primary origin. J Surg Oncol. 1998;67:255–260
  3. Johnston AD. Pathology of metastatic tumors in bone. Clin Orthop Relat Res. 1970;73:8–32
  4. Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treat Rev. 2001;27:165–176
  5. Papac RJ. Bone marrow metastases. A review. Cancer. 1994;74:2403–2413
  6. Arkenau HT, Mussig O, Buhr T, et al. Microangiopathic hemolytic anemia (MAHA) as paraneoplastic syndrome in metastasized signet ring cell carcinomas: case reports and review of the literature. Z Gastroenterol. 2005;43:719–722
  7. Burnell I, Tomkinson A, Hourihan M, et al. Mucin-secreting papillary adenocarcinoma of the hyoid bone: a unique case. J Laryngol Otol. 2005;119:498–502
  8. Millar AJ, Sinclair-Smith C, Mills AE, et al. Mucin-secreting Wilms tumor. Report of two cases. Am J Pediatr Hematol Oncol. 1990;12:201–204
  9. Wong KF, Chan JK, Ma SK. Solid tumour with initial presentation in the bone marrow—a clinicopathologic study of 25 adult cases. Hematol Oncol. 1993;11:35–42
  10. Jardin F, Vasse M, Debled M, et al. Intense paraneoplastic neutrophilic leukemoid reaction related to a G-CSF–secreting lung sarcoma. Am J Hematol. 2005;80:243–245
  11. Nasr F, Corti C, Carde P, et al. Carcinoma cell leukemia. Blood. 1996;88:2355–2357
  12. Han X, Bueso-Ramos CE. Advances in the pathological diagnosis and biology of acute lymphoblastic leukemia. Ann Diagn Pathol. 2005;9:239–257
  13. Sandberg AA, Stone JF, Czarnecki L, et al. Hematologic masquerade of rhabdomyosarcoma. Am J Hematol. 2001;68:51–57
  14. Ali R, Ozkalemkas F, Ozcelik T, et al. Small cell lung cancer presenting as acute leukaemia. Cytopathology. 2005;16:262–263
  15. Braun S, Naume B. Circulating and disseminated tumor cells. J Clin Oncol. 2005;23:1623–1626
  16. Mehes G, Witt A, Kubista E, et al. Circulating breast cancer cells are frequently apoptotic. Am J Pathol. 2001;159:17–20
  17. Nosanchuk J, Terzian J, Posso M. Circulating mucopolysaccharide (mucin) in two adults with metastatic adenocarcinoma. Detection in peripheral blood smear and at autopsy. Arch Pathol Lab Med. 1987;111:545–548
  18. Jatoi A, Dallal GE, Nguyen PL. False-negative rates of tumor metastases in the histologic examination of bone marrow. Mod Pathol. 1999;12:29–32
  19. Barekman CL, Fair KP, Cotelingam JD. Comparative utility of diagnostic bone-marrow components: a 10-year study. Am J Hematol. 1997;56:37–41
  20. Moid F, DePalma L. Comparison of relative value of bone marrow aspirates and bone marrow trephine biopsies in the diagnosis of solid tumor metastasis and Hodgkin lymphoma: institutional experience and literature review. Arch Pathol Lab Med. 2005;129:497–501
  21. Konoplev S, Bueso-Ramos CE. Advances in the pathologic diagnosis and biology of acute myeloid leukemia. Ann Diagn Pathol. 2006;10:39–65
  22. Burger JA, Kipps TJ. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood. 2006;107:1761–1767
  23. Yoneda T, Hiraga T. Crosstalk between cancer cells and bone microenvironment in bone metastasis. Biochem Biophys Res Commun. 2005;328:679–687
  24. Kucia M, Reca R, Miekus K, et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells. 2005;23:879–894
  25. Libura J, Drukala J, Majka M, et al. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. Blood. 2002;100:2597–2606
  26. Hart CA, Brown M, Bagley S, et al. Invasive characteristics of human prostatic epithelial cells: understanding the metastatic process. Br J Cancer. 2005;92:503–512
  27. Bakewell SJ, Nestor P, Prasad S, et al. Platelet and osteoclast beta3 integrins are critical for bone metastasis. Proc Natl Acad Sci U S A. 2003;100:14205–14210
  28. Sohara Y, Shimada H, DeClerck YA. Mechanisms of bone invasion and metastasis in human neuroblastoma. Cancer Lett. 2005;228:203–209
  29. Thomas RJ, Guise TA, Yin JJ, et al. Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology. 1999;140:4451–4458
  30. Dimitroff CJ, Descheny L, Trujillo N, et al. Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand–1 and E-selectin ligand–1, on human metastatic prostate tumor cells. Cancer Res. 2005;65:5750–5760
  31. Sipkins DA, Wei X, Wu JW, et al. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature. 2005;435:969–973
  32. Hill A, McFarlane S, Johnston PG, et al. The emerging role of CD44 in regulating skeletal micrometastasis. Cancer Lett. 2005;[Epub ahead of print]
  33. Kozlow W, Guise TA. Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy. J Mammary Gland Biol Neoplasia. 2005;10:169–180
  34. Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438:820–827
  35. Goltzman D, Karaplis AC, Kremer R, et al. Molecular basis of the spectrum of skeletal complications of neoplasia. Cancer. 2000;88:2903–2908
  36. Price JT, Quinn JM, Sims NA, et al. The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line. Cancer Res. 2005;65:4929–4938
  37. Pantel K, Woelfle U. Detection and molecular characterisation of disseminated tumour cells: implications for anti-cancer therapy. Biochim Biophys Acta. 2005;1756:53–64
  38. Hayes DF. Prognostic and predictive factors revisited. Breast. 2005;14:493–499
  39. Muller V, Stahmann N, Riethdorf S, et al. Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res. 2005;11:3678–3685
  40. O'Connor OJ, Cahill RA, Kirwan WO, et al. The impact of bone marrow micrometastases on metastatic disease-free survival in patients with colorectal carcinoma. Colorectal Dis. 2005;7:406–409
  41. Wiedswang G, Borgen E, Karesen R, et al. Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J Clin Oncol. 2003;21:3469–3478
  42. Muller V, Pantel K. Bone marrow micrometastases and circulating tumor cells: current aspects and future perspectives. Breast Cancer Res. 2004;6:258–261
  43. Ihde DC, Simms EB, Matthews MJ, et al. Bone marrow metastases in small cell carcinoma of the lung: frequency, description, and influence on chemotherapeutic toxicity and prognosis. Blood. 1979;53:677–686
  44. Clamon GH, Edwards WR, Hamous JE, et al. Patterns of bone marrow involvement with small cell lung cancer. Cancer. 1984;54:100–102
  45. Schlette E, Medeiros LJ, Beran M, et al. Indolent neuroendocrine tumor involving the bone marrow. A case report with a 9-year follow-up. Arch Pathol Lab Med. 2003;127:488–491
  46. Muggia FM, Hansen HH. Osteoblastic metastases in small-cell (oat-cell) carcinoma of the lung. Cancer. 1972;30:801–805
  47. Iguchi T, Awaya N, Kobayashi K, et al. Bone marrow metastasis of small cell carcinoma of the lung mimicking Burkitt lymphoma/leukaemia. Br J Haematol. 2005;130:652
  48. Hansen HH, Muggia FM, Selawry OS. Bone-marrow examination in 100 consecutive patients with bronchogenic carcinoma. Lancet. 1971;2:443–445
  49. Ridell B, Landys K. Incidence and histopathology of metastases of mammary carcinoma in biopsies from the posterior iliac crest. Cancer. 1979;44:1782–1788
  50. Ingle JN, Tormey DC, Tan HK. The bone marrow examination in breast cancer: diagnostic considerations and clinical usefulness. Cancer. 1978;41:670–674
  51. Landys K. Prognostic value of bone marrow biopsy in breast cancer. Cancer. 1982;49:513–518
  52. DiStefano A, Tashima CK, Yap HY, et al. Bone marrow metastases without cortical bone involvement in breast cancer patients. Cancer. 1979;44:196–198
  53. Coleman RE, Smith P, Rubens RD. Clinical course and prognostic factors following bone recurrence from breast cancer. Br J Cancer. 1998;77:336–340
  54. Borst MJ, Ingold JA. Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 1993;114:637–641[discussion 41-2]
  55. Ferlicot S, Vincent-Salomon A, Medioni J, et al. Wide metastatic spreading in infiltrating lobular carcinoma of the breast. Eur J Cancer. 2004;40:336–341
  56. Jain S, Fisher C, Smith P, et al. Patterns of metastatic breast cancer in relation to histological type. Eur J Cancer. 1993;29A:2155–2157
  57. Ninomiya J, Oyama T, Horiguchi J, et al. Two cases of breast cancer with cartilaginous and osseous metaplasia. Breast Cancer. 2005;12:52–56
  58. El Omari-Alaoui H, Lahdiri I, Nejjar I, et al. Male breast cancer. A report of 71 cases. Cancer Radiother. 2002;6:349–351
  59. Deeming G, Divakaran R, Butterworth D, et al. Temporomandibular region metastasis from cystosarcoma phyllodes: a case report and review of the literature. J Craniomaxillofac Surg. 2003;31:325–328
  60. Cote RJ, Rosen PP, Lesser ML, et al. Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases. J Clin Oncol. 1991;9:1749–1756
  61. Lehr JE, Pienta KJ. Preferential adhesion of prostate cancer cells to a human bone marrow endothelial cell line. J Natl Cancer Inst. 1998;90:118–123
  62. Schneider A, Kalikin LM, Mattos AC, et al. Bone turnover mediates preferential localization of prostate cancer in the skeleton. Endocrinology. 2005;146:1727–1736
  63. Roudier MP, True LD, Higano CS, et al. Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone. Hum Pathol. 2003;34:646–653
  64. Lim KH, Huang MJ, Yang S, et al. Primary carcinoid tumor of prostate presenting with bone marrow metastases. Urology. 2005;65:174
  65. Jonas S, Weinrich M, Tullius SG, et al. Microscopic tumor cell dissemination in gastric cancer. Surg Today. 2004;34:101–106
  66. Chung YS, Choi TY, Ha CY, et al. An unusual case of osteoblastic metastasis from gastric carcinoma. Yonsei Med J. 2002;43:377–380
  67. Kobayashi M, Okabayashi T, Sano T, et al. Metastatic bone cancer as a recurrence of early gastric cancer—characteristics and possible mechanisms. World J Gastroenterol. 2005;11:5587–5591
  68. Plockinger U, Wiedenmann B. Endocrine tumours of the gastrointestinal tract. Management of metastatic endocrine tumours. Best Pract Res Clin Gastroenterol. 2005;19:553–576
  69. Kaya G, Pasche C, Osterheld MC, et al. Primary neuroendocrine carcinoma of the liver: an autopsy case. Pathol Int. 2001;51:874–878
  70. Ohike N, Morohoshi T. Pathological assessment of pancreatic endocrine tumors for metastatic potential and clinical prognosis. Endocr Pathol. 2005;16:33–40
  71. Casas F, Ferrer F, Farrus B, et al. Primary small cell carcinoma of the esophagus: a review of the literature with emphasis on therapy and prognosis. Cancer. 1997;80:1366–1372
  72. Wu Z, Ma JY, Yang JJ, et al. Primary small cell carcinoma of esophagus: report of 9 cases and review of literature. World J Gastroenterol. 2004;10:3680–3682
  73. Jaehne M, Roeser K, Jaekel T, et al. Clinical and immunohistologic typing of salivary duct carcinoma: a report of 50 cases. Cancer. 2005;103:2526–2533
  74. Terhaard CH, Lubsen H, Van der Tweel I, et al. Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck. 2004;26:681–692[discussion 92-3]
  75. Wenig BM, Hitchcock CL, Ellis GL, et al. Metastasizing mixed tumor of salivary glands. A clinicopathologic and flow cytometric analysis. Am J Surg Pathol. 1992;16:845–858
  76. Fu KK, Leibel SA, Levine ML, et al. Carcinoma of the major and minor salivary glands: analysis of treatment results and sites and causes of failures. Cancer. 1977;40:2882–2890
  77. Lima RA, Tavares MR, Dias FL, et al. Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg. 2005;133:702–708
  78. Sutcliffe R, Maguire D, Murphy P, et al. Detection and clinical significance of bone marrow micrometastases in patients undergoing liver transplantation for hepatocellular carcinoma. Transplantation. 2005;80:88–94
  79. Lee YT. Leiomyosarcoma of the gastro-intestinal tract: general pattern of metastasis and recurrence. Cancer Treat Rev. 1983;10:91–101
  80. Nabeshima S, Kishihara Y, Nabeshima A, et al. Poorly differentiated adenocarcinoma with signet-ring cells of the Vater's ampulla, without jaundice but with disseminated carcinomatosis. Fukuoka Igaku Zasshi. 2003;94:235–240
  81. Flanigan RC, Campbell SC, Clark JI, et al. Metastatic renal cell carcinoma. Curr Treat Options Oncol. 2003;4:385–390
  82. Kuczyk MA, Anastasiadis AG, Zimmermann R, et al. Current aspects of the surgical management of organ-confined, metastatic, and recurrent renal cell cancer. BJU Int. 2005;96:721–727[quiz i-ii]
  83. De Vos C, Gerard JM, Decat M, et al. Metastatic renal cell carcinoma to the temporal bone: case report. B-ENT. 2005;1:43–46
  84. Tongaonkar HB, Kulkarni JN, Kamat MR. Solitary metastases from renal cell carcinoma: a review. J Surg Oncol. 1992;49:45–48
  85. Altinoz MA, Santaguida C, Guiot MC, et al. Spinal hemangioblastoma containing metastatic renal cell carcinoma in von Hippel-Lindau disease. Case report and review of the literature. J Neurosurg Spine. 2005;3:495–500
  86. Medeiros LJ, Wolf BC, Balogh K, et al. Adrenal pheochromocytoma: a clinicpathologic review of 60 cases. Human Pathol. 1985;16:580–589
  87. Cohn-Cedermark G, Mansson-Brahme E, Rutqvist LE, et al. Metastatic patterns, clinical outcome, and malignant phenotype in malignant cutaneous melanoma. Acta Oncol. 1999;38:549–557
  88. Spiller SE, Hawkins DS, Finn LS, et al. Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy. Pediatr Blood Cancer. 2005;45:60–63
  89. Baloch ZW, Sack MJ, Yu GH, et al. Papillary formations in metastatic melanoma. Diagn Cytopathol. 1999;20:148–151
  90. Saikia B, Varma N, Mohan C, et al. Metastatic bone marrow involvement by squamous cell carcinoma of the tonsil. J Otolaryngol. 2002;31:184–186
  91. Ting PT, Kasper R, Arlette JP. Metastatic basal cell carcinoma: report of two cases and literature review. J Cutan Med Surg. 2005;9:10–15
  92. Knoeller SM, Haag M, Adler CP, et al. Skeletal metastasis in tricholemmal carcinoma. Clin Orthop Relat Res. 2004;213–216
  93. Meyer TK, Rhee JS, Smith MM, et al. External auditory canal eccrine spiradenocarcinoma: a case report and review of literature. Head Neck. 2003;25:505–510
  94. Kamijo A, Koshino T, Hirakawa K, et al. Merkel cell carcinoma with bone metastasis: a case report. J Orthop Sci. 2002;7:574–577
  95. Clark JR, Lai P, Hall F, et al. Variables predicting distant metastases in thyroid cancer. Laryngoscope. 2005;115:661–667
  96. Kumar PV, Monabati A, Tabei SZ, et al. Metastatic follicular thyroid carcinoma diagnosed by fine needle aspiration cytology: a report of 3 cases. Acta Cytol. 2005;49:177–180
  97. Weber T, Lacroix J, Worner S, et al. Detection of hematogenic and lymphogenic tumor cell dissemination in patients with medullary thyroid carcinoma by cytokeratin 20 and preprogastrin-releasing peptide RT-PCR. Int J Cancer. 2003;103:126–131
  98. Favia G, Lumachi F, Polistina F, et al. Parathyroid carcinoma: sixteen new cases and suggestions for correct management. World J Surg. 1998;22:1225–1230
  99. George J, Lai FM. Metastatic cervical carcinoma presenting as psoas abscess and osteoblastic and lytic bony metastases. Singapore Med J. 1995;36:224–227
  100. Ratanatharathorn V, Powers WE, Steverson N, et al. Bone metastasis from cervical cancer. Cancer. 1994;73:2372–2379
  101. Uharcek P, Mlyncek M, Ravinger J. Endometrial adenocarcinoma presenting with an osseous metastasis. Gynecol Obstet Invest. 2006;61:200–202
  102. Punyavoravut V, Nelson SD. Diffuse bony metastasis from transitional cell carcinoma of urinary bladder: a case report and review of literature. J Med Assoc Thai. 1999;82:839–843
  103. Sengelov L, Kamby C, von der Maase H. Pattern of metastases in relation to characteristics of primary tumor and treatment in patients with disseminated urothelial carcinoma. J Urol. 1996;155:111–114
  104. Sengelov L, von der Maase H, Kamby C, et al. Assessment of patients with metastatic transitional cell carcinoma of the urinary tract. J Urol. 1999;162:343–346
  105. Matthews PN, Madden M, Bidgood KA, et al. The clinicopathological features of metastatic superficial papillary bladder cancer. J Urol. 1984;132:904–906
  106. Evison G, Pizey N, Roylance J. Bone formation associated with osseous metastases from bladder carcinoma. Clin Radiol. 1981;32:303–309
  107. Petkovic M, Muhvic D, Zamolo G, et al. Metatarsal metastasis from transitional cell cancer of the urinary bladder. Coll Antropol. 2004;28:337–341
  108. Liel Y, Maor E, Ariad S, et al. Severe, diffuse osteosclerosis: a new manifestation of transitional cell carcinoma of the urinary bladder. Calcif Tissue Int. 1998;63:471–474
  109. Shimizu K, Imaida K. Metastatic transitional cell carcinoma or nonsecretory multiple myeloma?. Clin Lab Haematol. 2001;23:67
  110. Calaminus G, Schneider DT, Bokkerink JP, et al. Prognostic value of tumor size, metastases, extension into bone, and increased tumor marker in children with malignant sacrococcygeal germ cell tumors: a prospective evaluation of 71 patients treated in the German cooperative protocols Maligne Keimzelltumoren (MAKEI) 83/86 and MAKEI 89. J Clin Oncol. 2003;21:781–786
  111. Johnson DE, Appelt G, Samuels ML, et al. Metastases from testicular carcinoma. Study of 78 autopsied cases. Urology. 1976;8:234–239
  112. Hermann G, Novick A, Carr L. Skeletal metastases of seminoma of the testicle. Mt Sinai J Med. 1986;53:294–296
  113. Merrick MV. Bone scintigraphy in testicular tumours. Br J Urol. 1987;60:167–169
  114. Korfel A, Fischer L, Foss HD, et al. Testicular germ cell tumor with rhabdomyosarcoma successfully treated by disease-adapted chemotherapy including high-dose chemotherapy: case report and review of the literature. Bone Marrow Transplant. 2001;28:787–789
  115. Uygun K, Karagol H, Kocak Z, et al. Isolated bone metastasis in testicular germ cell tumors: a case report and review of the literature. Onkologie. 2006;29:93–95
  116. Wenger DE, Wold LE, et al. Malignant vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol. 2000;29:619–631
  117. Miura K, Hatori M, Hosaka M, et al. Primary leiomyosarcoma with the invasion into the intertrabecular space of bone: a case report and the review of the literatures. Clin Imaging. 2001;25:209–214
  118. Ricchetti T, Paci M, Cavazza A, et al. A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma. Tumori. 2005;91:210–212
  119. Fury MG, Antonescu CR, Van Zee KJ, et al. A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy. Cancer J. 2005;11:241–247
  120. Wang C, Rabah R, Blackstein M, et al. Bone marrow metastasis of angiosarcoma. Pathol Res Pract. 2004;200:551–555
  121. Yilmazlar T, Kirdak T, Adim S, et al. A case of hemangiosarcoma in thyroid with severe anemia due to bone marrow metastasis. Endocr J. 2005;52:57–59
  122. Bruland OS, Hoifodt H, Saeter G, et al. Hematogenous micrometastases in osteosarcoma patients. Clin Cancer Res. 2005;11:4666–4673
  123. Wang LL. Biology of osteogenic sarcoma. Cancer J. 2005;11:294–305
  124. Kawano T, Hamada J, Morioka M, et al. Skull metastasis from clear cell chondrosarcoma. Neurol Med Chir (Tokyo). 2005;45:367–370
  125. Bramwell VH, Littley MB, Chang J, et al. Bone marrow involvement in adult soft tissue sarcomas. Eur J Cancer Clin Oncol. 1982;18:1099–1106
  126. Enam SA, Abdulrauf S, Mehta B, et al. Metastasis in meningioma. Acta Neurochir (Wien). 1996;138:1172–1177[discussion 7-8]
  127. Rajagopalan V, Kamar FG, Thayaparan R, et al. Bone marrow metastases from glioblastoma multiforme—a case report and review of the literature. J Neurooncol. 2005;72:157–161
  128. Giordana MT, Ghimenti C, Leonardo E, et al. Molecular genetic study of a metastatic oligodendroglioma. J Neurooncol. 2004;66:265–271
  129. Al-Ali F, Hendon AJ, Liepman MK, et al. Oligodendroglioma metastatic to bone marrow. AJNR Am J Neuroradiol. 2005;26:2410–2414
  130. Anand M, Kumar R, Jain P, et al. Metastatic anaplastic oligodendroglioma simulating acute leukemia. A case report. Acta Cytol. 2003;47:467–469
  131. Farrier SE, Agosti S, Morgan M, et al. Metastatic ependymoma manifested by pancytopenia. South Med J. 1994;87:1262–1263
  132. Constantine C, Miller DC, Gardner S, et al. Osseous metastasis of pineoblastoma: a case report and review of the literature. J Neurooncol. 2005;74:53–57
  133. Shimada H, Ambros IM, Dehner LP, et al. The International Neuroblastoma Pathology Classification (the Shimada system). Cancer. 1999;86:364–372
  134. Mills AE, Bird AR. Bone marrow changes in neuroblastoma. Pediatr Pathol. 1986;5:225–234
  135. Reid MM, Hamilton PJ. Histology of neuroblastoma involving bone marrow: the problem of detecting residual tumour after initiation of chemotherapy. Br J Haematol. 1988;69:487–490
  136. Lonergan GJ, Schwab CM, Suarez ES, et al. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 2002;22:911–934
  137. Russell HV, Golding LA, Suell MN, et al. The role of bone marrow evaluation in the staging of patients with otherwise localized, low-risk neuroblastoma. Pediatr Blood Cancer. 2005;45:916–919
  138. Escobar MA, Grosfeld JL, Powell RL, et al. Long-term outcomes in patients with stage IV neuroblastoma. J Pediatr Surg. 2006;41:377–381
  139. Raney RB, Anderson JR, Barr FG, et al. Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: a selective review of intergroup rhabdomyosarcoma study group experience and rationale for Intergroup Rhabdomyosarcoma Study V. J Pediatr Hematol Oncol. 2001;23:215–220
  140. Carli M, Colombatti R, Oberlin O, et al. European intergroup studies (MMT4-89 and MMT4-91) on childhood metastatic rhabdomyosarcoma: final results and analysis of prognostic factors. J Clin Oncol. 2004;22:4787–4794
  141. Miyoshi I, Uemura Y, Muneishi H, et al. Bone marrow metastasis of alveolar rhabdomyosarcoma. Intern Med. 2005;44:677–678
  142. Chen L, Shah HO, Lin JH. Alveolar rhabdomyosarcoma with concurrent metastases to bone marrow and lymph nodes simulating acute hematologic malignancy. J Pediatr Hematol Oncol. 2004;26:696–697
  143. Rickert CH. Extraneural metastases of paediatric brain tumours. Acta Neuropathol (Berl). 2003;105:309–327
  144. Eberhart CG, Cohen KJ, Tihan T, et al. Medulloblastomas with systemic metastases: evaluation of tumor histopathology and clinical behavior in 23 patients. J Pediatr Hematol Oncol. 2003;25:198–203
  145. Kunschner LJ, Kuttesch J, Hess K, et al. Survival and recurrence factors in adult medulloblastoma: the M.D. Anderson Cancer Center experience from 1978 to 1998. Neuro-oncol. 2001;3:167–173
  146. Koscielniak E, Morgan M, Treuner J. Soft tissue sarcoma in children: prognosis and management. Paediatr Drugs. 2002;4:21–28
  147. Folpe AL, Goldblum JR, Rubin BP, et al. Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases. Am J Surg Pathol. 2005;29:1025–1033
  148. Lazda EJ, Berry PJ. Bone marrow metastasis in Ewing's sarcoma and peripheral primitive neuroectodermal tumor: an immunohistochemical study. Pediatr Dev Pathol. 1998;1:125–130
  149. Bernstein ML, Devidas M, Lafreniere D, et al. Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457—a report from the Children's Oncology Group. J Clin Oncol. 2006;24:152–159

PII: S1092-9134(06)00048-7

doi: 10.1016/j.anndiagpath.2006.04.001

Annals of Diagnostic Pathology
Volume 10, Issue 3 , Pages 169-192 , June 2006

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