Annals of Diagnostic Pathology
Volume 11, Issue 5 , Pages 358-362 , October 2007

True thymic hyperplasia associated with severe thymic cyst bleeding in a newborn: case report and review of the literature

  • Frank Eifinger, MD

      Affiliations

    • Department of Neonatology and Neonatal Intensive Care Unit, Children's Hospital, University of Cologne, Joseph-Stelzmann Strasse 9, D-50923 Cologne, Germany
    • ,
  • Karin Ernestus, MD

      Affiliations

    • Institute of Pathology, University of Cologne, Joseph-Stelzmann Strasse 9, D-50923 Cologne, Germany
    • ,
  • Gabriele Benz-Bohm, MD

      Affiliations

    • Department of Diagnostic Radiology, Paediatric Radiology, University of Cologne, Joseph-Stelzmann Strasse 9, D-50923 Cologne, Germany
    • ,
  • Friederike Körber, MD

      Affiliations

    • Department of Diagnostic Radiology, Paediatric Radiology, University of Cologne, Joseph-Stelzmann Strasse 9, D-50923 Cologne, Germany
    • ,
  • Christoph Hünseler, MD

      Affiliations

    • Department of Neonatology and Neonatal Intensive Care Unit, Children's Hospital, University of Cologne, Joseph-Stelzmann Strasse 9, D-50923 Cologne, Germany
    • ,
  • Khosro Hekmat, MD

      Affiliations

    • Department of Cardiothoracic Surgery, University of Cologne, Joseph-Stelzmann Strasse 9, D-50923 Cologne, Germany
    • ,
  • Alexander Marx, MD

      Affiliations

    • Institute of Pathology, University of Wuerzburg, Josef-Schneider Strasse 2, D-97080 Wuerzburg, Germany
    • ,
  • Bernhard Roth, MD

      Affiliations

    • Department of Neonatology and Neonatal Intensive Care Unit, Children's Hospital, University of Cologne, Joseph-Stelzmann Strasse 9, D-50923 Cologne, Germany

References 

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  2. Woolley MM, Isaacs H, Lindesmith G, et al. Spontaneous thymic hemorrhage in the neonate: report of two cases. J Pediatr Surg. 1974;9(2):231–233
  3. Lemaitre L, Leclerc F, Dubos JP, et al. Thymic hemorrhage: a cause of acute symptomatic mediastinal widening in an infant with late hemorrhagic disease. Sonographic findings. Pediatr Radiol. 1989;19(2):128–129
  4. Walsh SV, Cooke R, Mortimer G, et al. Massive thymic hemorrhage in a neonate: an entity revisited. J Pediatr Surg. 1996;31(9):1315–1317
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  6. Koopman LP, Plotz FB, Meuzelaar JJ, et al. Thymic cyst haemorrhages and transient cholestasis in a 4-week-old infant. Eur J Pediatr. 1998;157(3):236–238
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  11. Levine GD, Rosai J. Thymic hyperplasia and neoplasia: a review of current concepts. Hum Pathol. 1978;9(5):495–515
  12. Lamesch AJ. Massive thymic hyperplasia in infants. Bull Soc Sci Med Grand Duche Luxemb. 1988;125;[Spec No: 20-4]
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  14. Pedroza MA, Larenas-Linnemann D. Thymus hyperplasia, differential diagnosis in the wheezing infant. Allergol Immunopathol (Madr). 1997;25(2):59–62
  15. Woywodt A, Verhaart S, Kiss A. Massive true thymic hyperplasia. Eur J Pediatr Surg. 1999;9(5):331–333
  16. Dimitriou G, Greenough A, Rafferty G, et al. Respiratory distress in a neonate with an enlarged thymus. Eur J Pediatr. 2000;159(4):237–238
  17. Tareen FK, Hussain S, Moazam F. Thymic hyperplasia: a cause of respiratory distress. J Pak Med Assoc. 2001;51(8):300–302
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  19. Woolley MM, Isaacs H, Lindesmith G, et al. Spontaneous thymic hemorrhage in the neonate: report of two cases. J Pediatr Surg. 1974;9(2):231–233
  20. Filler RM, Simpson JS, Ein SH. Mediastinal masses in infants and children. Pediatr Clin North Am. 1979;26(3):677–690
  21. Oh KS, Weber AL, Borden S. Normal mediastinal mass in late childhood. Radiology. 1971;101(3):625–628
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  24. Ewerbeck H. Der Säugling. 1st ed.. Berlin: Springer-Verlag; 1962;
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  27. Hammer JA. Thymus in Gesundheit und Krankeit, Part I. Das normale Organ. Z Mikrosk Anat Forsch. 1926;6:107–208
  28. Ricci C, Pescarmona E, Rendina EA, et al. True thymic hyperplasia: a clinicopathological study. Ann Thorac Surg. 1989;47(5):741–745
  29. Speer FD. Thymic cysts. Bull N Y Med Col. 1938;1:142–150
  30. van Sonnenberg E, Simeone JF, Mueller PR, et al. Sonographic appearance of hematoma in liver, spleen, and kidney: a clinical, pathologic, and animal study. Radiology. 1983;147(2):507–510
  31. Carroll BA, Ta HN. The ultrasonic appearance of extranodal abdominal lymphoma. Radiology. 1980;136(2):419–425
  32. Scharifker D. True thymic hyperplasia associated with a unilocular thymic cyst: an unusual combination not previously reported. Ann Diagn Pathol. 2006;10(1):32–35
  33. Boyd E. Growth of the thymus, its relation to status thymicolymphaticus and thymic symptoms. Am J Dis Child. 1927;33:867
  34. Young M, Turnball HM. An analysis of the data collected by the status lymphaticus investigation commitee. J Pathol Bacteriol. 1931;34:213–227
  35. Sauter ER, Arensman RM, Falterman KW. Thymic enlargement in children. Am Surg. 1991;57(1):21–23

PII: S1092-9134(06)00054-2

doi: 10.1016/j.anndiagpath.2006.04.007

Annals of Diagnostic Pathology
Volume 11, Issue 5 , Pages 358-362 , October 2007

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