Annals of Diagnostic Pathology
Volume 11, Issue 1 , Pages 55-60 , February 2007

Unusual expression of CD94 on CD8+ TCR-αβ T cells in infectious mononucleosis

  • Yongsheng Ren, MD, PhD

      Affiliations

    • Department of Hematopathology, Box 72, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • L. Jeffrey Medeiros, MD

      Affiliations

    • Department of Hematopathology, Box 72, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Hesham M. Amin, MD

      Affiliations

    • Department of Hematopathology, Box 72, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Michael E. Rytting, MD

      Affiliations

    • Department of Pediatrics, Box 72, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Jeffrey L. Jorgensen, MD, PhD

      Affiliations

    • Department of Hematopathology, Box 72, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Weina Chen, MD, PhD

      Affiliations

    • Department of Hematopathology, Box 72, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 314 648 5196; fax: +1 214 645 6315.

References 

  1. Vilches C, Parham P. KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu Rev Immunol. 2002;20:217–251
  2. Moretta A, Biassoni R, Bottino C, et al. Major histocompatibility complex class I–specific receptors on human natural killer and T lymphocytes. Immunol Rev. 1997;155:105–117
  3. Gunturi A, Berg RE, Forman J. The role of CD94/NKG2 in innate and adaptive immunity. Immunol Res. 2004;30:29–34
  4. Vivier E, Anfossi N. Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future. Nat Rev Immunol. 2004;4:190–198
  5. Hoffmann T, De Libero G, Colonna M, et al. Natural killer–type receptors for HLA class I antigens are clonally expressed in lymphoproliferative disorders of natural killer and T-cell type. Br J Haematol. 2000;110:525–536
  6. Lundell R, Hartung L, Hill S, et al. T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules. Am J Clin Pathol. 2005;124:937–946
  7. Morice WG, Kurtin PJ, Leibson PJ, et al. Demonstration of aberrant T-cell and natural killer-cell antigen expression in all cases of granular lymphocytic leukaemia. Br J Haematol. 2003;120:1026–1036
  8. Morice WG, Macon WR, Dogan A, et al. NK-cell–associated receptor expression in hepatosplenic T-cell lymphoma, insights into pathogenesis. Leukemia. 2006;20:883–886
  9. Galiani MD, Aguado E, Tarazona R, et al. Expression of killer inhibitory receptors on cytotoxic cells from HIV-1–infected individuals. Clin Exp Immunol. 1999;115:472–476
  10. McMahon CW, Zajac AJ, Jamieson AM, et al. Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. J Immunol. 2002;169:1444–1452
  11. Gunturi A, Berg RE, Forman J. Preferential survival of CD8 T and NK cells expressing high levels of CD94. J Immunol. 2003;170:1737–1745
  12. Poon K, Montamat-Sicotte D, Cumberbatch N, et al. Expression of leukocyte immunoglobulin-like receptors and natural killer receptors on virus-specific CD8+ T cells during the evolution of Epstein-Barr virus–specific immune responses in vivo. Viral Immunol. 2005;18:513–522
  13. Lima M, Teixeira M dos A, Queiros ML, et al. Immunophenotype and TCR-Vbeta repertoire of peripheral blood T-cells in acute infectious mononucleosis. Blood Cells Mol Dis. 2003;30:1–12
  14. Schlette E, Medeiros LJ, Keating M, et al. CD79b expression in chronic lymphocytic leukemia. Association with trisomy 12 and atypical immunophenotype. Arch Pathol Lab Med. 2003;127:561–566
  15. Morice WG, Kimlinger T, Katzmann JA, et al. Flow cytometric assessment of TCR-Vbeta expression in the evaluation of peripheral blood involvement by T-cell lymphoproliferative disorders: a comparison with conventional T-cell immunophenotyping and molecular genetic techniques. Am J Clin Pathol. 2004;121:373–383
  16. Vega F, Medeiros LJ, Jones D, et al. A novel four-color PCR assay to assess T-cell receptor gamma gene rearrangements in lymphoproliferative lesions. Am J Clin Pathol. 2001;116:17–24
  17. Hudnall SD, Patel J, Schwab H, et al. Comparative immunophenotypic features of EBV-positive and EBV-negative atypical lymphocytosis. Cytometry B Clin Cytom. 2003;55:22–28
  18. Kim DK, Kabat J, Borrego F, et al. Human NKG2F is expressed and can associate with DAP12. Mol Immunol. 2004;41:53–62
  19. Glienke J, Sobanov Y, Brostjan C, et al. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. Immunogenetics. 1998;48:163–173
  20. Le Drean E, Vely F, Olcese L, et al. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. Eur J Immunol. 1998;28:264–276
  21. Lanier LL, Corliss B, Wu J, et al. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity. 1998;8:693–701
  22. Lanier LL. NK cell recognition. Annu Rev Immunol. 2005;23:225–274
  23. Ugolini S, Arpin C, Anfossi N, et al. Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells. Nat Immunol. 2001;2:430–435
  24. Andre P, Brunet C, Guia S, et al. Differential regulation of killer cell Ig-like receptors and CD94 lectin-like dimers on NK and T lymphocytes from HIV-1–infected individuals. Eur J Immunol. 1999;29:1076–1085
  25. Mingari MC, Ponte M, Vitale C, et al. Expression of HLA class I–specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controls T-cell activation and function. Hum Immunol. 2000;61:44–50
  26. Mingari MC, Pietra G, Moretta L. Human cytolytic T lymphocytes expressing HLA class-I–specific inhibitory receptors. Curr Opin Immunol. 2005;17:312–319
  27. Mingari MC, Ponte M, Bertone S, et al. HLA class I–specific inhibitory receptors in human T lymphocytes: interleukin 15–induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells. Proc Natl Acad Sci U S A. 1998;95:1172–1177
  28. Derre L, Corvaisier M, Pandolfino MC, et al. Expression of CD94/NKG2-A on human T lymphocytes is induced by IL-12: implications for adoptive immunotherapy. J Immunol. 2002;168:4864–4870
  29. Jamal S, Picker LJ, Aquino DB, et al. Immunophenotypic analysis of peripheral T-cell neoplasms. A multiparameter flow cytometric approach. Am J Clin Pathol. 2001;116:512–526
  30. Weisberger J, Cornfield D, Gorczyca W, et al. Down-regulation of pan-T-cell antigens, particularly CD7, in acute infectious mononucleosis. Am J Clin Pathol. 2003;120:49–55

PII: S1092-9134(06)00077-3

doi: 10.1016/j.anndiagpath.2006.06.005

Annals of Diagnostic Pathology
Volume 11, Issue 1 , Pages 55-60 , February 2007