Annals of Diagnostic Pathology
Volume 12, Issue 2 , Pages 142-145, April 2008

Sarcomatoid carcinoma after radiation treatment of prostatic adenocarcinoma

  • Youming Huan, MD

      Affiliations

    • Department of Pathology, Mount Sinai Medical Center, New York, P.O. Box 1194, New York, NY 10029, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 241 5955; fax: +1 212 289 2899.
    • ,
  • Muhammad Idrees, MD

      Affiliations

    • Department of Pathology, Mount Sinai Medical Center, New York, P.O. Box 1194, New York, NY 10029, USA
    • ,
  • Michael E. Gribetz, MD

      Affiliations

    • Department of Urology, Mount Sinai Medical Center, New York, NY 10029, USA
    • ,
  • Pamela D. Unger, MD

      Affiliations

    • Department of Pathology, Mount Sinai Medical Center, New York, P.O. Box 1194, New York, NY 10029, USA

published online 20 August 2007.

Abstract 

We report 2 patients with conventional prostatic adenocarcinoma who developed sarcomatoid carcinoma of probable prostatic origin 6 and 2.5 years after radiation treatment (seed implantation and external beam). Our cases had histologic features consistent with those cases previously reported in the literature. The tumors consisted of spindle cells with large hyperchromatic nuclei and a pattern mimicking a sarcoma. Immunohistochemical studies showed the tumors to be weakly positive for EMA, CK7, and vimentin. Ki67 staining showed positivity in more than 50% of tumor cells. The tumors also stained diffusely positive for p53 and p63. PSA and PAP were negative. Clinically, the sarcomatoid carcinomas appeared to be of prostatic origin. The pathogenesis of the tumors is still uncertain but most likely represent a radiation-induced dedifferentiation of prostatic adenocarcinoma.

Keywords: Sarcomatoid carcinoma, Postradiation sarcoma, Prostate, p63, p53

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1092-9134(06)00101-8

doi:10.1016/j.anndiagpath.2006.08.008

Annals of Diagnostic Pathology
Volume 12, Issue 2 , Pages 142-145, April 2008

Article Tools

* Image Usage & Resolution