Annals of Diagnostic Pathology
Volume 11, Issue 1 , Pages 13-21 , February 2007

Mucinous tubular and spindle cell carcinoma of kidney is probably a variant of papillary renal cell carcinoma with spindle cell features

  • Steven S. Shen, MD, PhD

      Affiliations

    • Department of Pathology, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
    • Department of Pathology, Weill Medical College of Cornell University, Houston, TX 77030, USA
    • Corresponding Author InformationCorresponding author. Department of Pathology, The Methodist Hospital and Research Institute, and Weill Medical College of Cornell University, Houston, TX 77030, USA. Tel.: +1 713 441 6987; fax: +1 713 793 1603.
    • ,
  • Jae Y. Ro, MD, PhD

      Affiliations

    • Department of Pathology, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
    • Department of Pathology, Weill Medical College of Cornell University, Houston, TX 77030, USA
    • ,
  • Pheroze Tamboli, MD

      Affiliations

    • Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Luan D. Truong, MD

      Affiliations

    • Department of Pathology, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
    • Department of Pathology, Weill Medical College of Cornell University, Houston, TX 77030, USA
    • ,
  • Qihui Zhai, MD

      Affiliations

    • Department of Pathology, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
    • Department of Pathology, Weill Medical College of Cornell University, Houston, TX 77030, USA
    • ,
  • Soo-Jin Jung, MD

      Affiliations

    • Department of Pathology, Inje University College of Medicine, Busan, Korea
    • ,
  • Rita G. Tibbs, MD

      Affiliations

    • Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Nelson G. Ordonez, MD

      Affiliations

    • Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Alberto G. Ayala, MD

      Affiliations

    • Department of Pathology, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
    • Department of Pathology, Weill Medical College of Cornell University, Houston, TX 77030, USA

References 

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  3. Srigley JR, Eble JN, Grignon DJ, Hartwick RWJ. Unusual renal cell carcinoma (RCC) with prominent spindle cell change possibly related to the loop of Henle. Mod Pathol. 1999;12:107A
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  5. MacLennan GT, Farrow GM, Bostwick DG. Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urology. 1997;50:679–684
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  8. Sun W, McGregor DK, Ordonez NG, Ayala AG, Caraway NP. Fine needle aspiration cytology of a low-grade myxoid renal epithelial neoplasm: a case report. Acta Cytol. 2006;49:525–529
  9. Rakozy C, Schmahl GE, Bogner S, Storkel S. Low-grade tubular-mucinous renal neoplasms: morphologic, immunohistochemical, and genetic features. Mod Pathol. 2002;15:1162–1171
  10. Srigley J, Kapusta LR, Reuter VE, et al. Phenotypic, molecular and ultrastructural studies of a novel low-grade renal neoplasm possible related to the loop of Henle. Mod Pathol. 2002;15:182
  11. Ferlicot S, Allory Y, Comperat E, et al. Mucinous tubular and spindle cell carcinoma: a report of 15 cases and a review of the literature. Virchows Arch. 2005;447:978–983
  12. Brandal P, Lie AK, Bassarova A, et al. Genomic aberrations in mucinous tubular and spindle cell renal cell carcinomas. Mod Pathol. 2005;19:186–194
  13. Paner GP, Srigley JR, Radhakrishnan A, et al. Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. Am J Surg Pathol. 2006;30:13–19
  14. Shen SS, Krishna B, Chirala R, Amato RJ, Truong LD. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol. 2005;18:933–940
  15. Yoshida SO, Imam A. Monoclonal antibody to a proximal nephrogenic renal antigen: immunohistochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinomas. Cancer Res. 1989;49:1802–1809
  16. Avery AK, Beckstead J, Renshaw AA, Corless CL. Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol. 2000;24:203–210
  17. McGregor DK, Khurana KK, Cao C, et al. Diagnosing primary and metastatic renal cell carcinoma: the use of the monoclonal antibody ‘Renal Cell Carcinoma Marker’. Am J Surg Pathol. 2001;25:1485–1492
  18. Lin F, Brown RE, Shen T, Yang XJ, Schuerch C. Immunohistochemical detection of P504S in primary and metastatic renal cell carcinomas. Appl Immunohistochem Mol Morphol. 2004;12:153–159
  19. Tretiakova MS, Sahoo S, Takahashi M, et al. Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. Am J Surg Pathol. 2004;28:69–76
  20. Ordonez NG. The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: a comparative study. Hum Pathol. 2004;35:697–710
  21. Delahunt B, Eble JN. Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. Mod Pathol. 1997;10:537–544
  22. Skinnider BF, Folpe AL, Hennigar RA, et al. Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors. Am J Surg Pathol. 2005;29:747–754
  23. Kuehn A, Cohen C, Radhakrishan A, et al. Expression of kidney-specific cadherin (Ksp-cad) in rare and unusual renal epithelial neoplasm. Diagnostic and histogenetic implications. Mod Pathol. 2006;19:145A
  24. Weber A, Srigley J, Moch H. Mucinous spindle cell carcinoma of the kidney. A molecular analysis. Pathologe. 2003;24:453–459
  25. Cossu-Rocca P, Eble JN, Delahunt B, et al. Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. Mod Pathol. 2006;19:488–493
  26. Jiang F, Richter J, Schraml P, et al. Chromosomal imbalances in papillary renal cell carcinoma: genetic differences between histological subtypes. Am J Pathol. 1998;153:1467–1473
  27. Renshaw AA, Richie JP. Subtypes of renal cell carcinoma. Different onset and sites of metastatic disease. Am J Clin Pathol. 1999;111:539–543
  28. Shen SS, Ro JY, Oak T, Amato RJ, Ayala AG, Truong LD. Metastatic renal cell carcinoma: patterns, histology and comparison to primary tumor. Mod Pathol. 2006;19:161A

PII: S1092-9134(06)00129-8

doi: 10.1016/j.anndiagpath.2006.09.005

Annals of Diagnostic Pathology
Volume 11, Issue 1 , Pages 13-21 , February 2007

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