Annals of Diagnostic Pathology
Volume 11, Issue 5 , Pages 326-329 , October 2007

Epidermal growth factor receptor is not amplified in schwannomas

  • Richard A. Prayson, MD

      Affiliations

    • Department of Anatomic Pathology (L25), Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 216 444 8805; fax: +1 216 445 6967.
    • ,
  • Brian J. Yoder

      Affiliations

    • Department of Anatomic Pathology (L25), Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    • ,
  • Gene H. Barnett

      Affiliations

    • Department of Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA

References 

  1. Layfield LJ, Wellmore C, Tripp S, et al. Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme. Prognostic significance and relationship to other prognostic factors. Appl Immunohistochem Mol Morphol. 2006;14:91–96
  2. Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol. 2003;21:2787–2799
  3. Anderson V, Guo D, Malmer B, et al. Epidermal growth factor receptor family (EGFR, Erb2-4) in gliomas and meningiomas. Acta Neuropathol. 2004;108:135–142
  4. Mischel PS, Shai R, Shi T, et al. Identification of molecular subtypes of glioblastoma by gene expression profiling. Oncogene. 2003;22:2361–2373
  5. Gullick WJ. Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers. Br Med Bull. 1991;47:87–98
  6. Ozanne B, Richards CS, Hendler F, et al. Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas. J Pathol. 1986;149:9
  7. Hurtt MR, Moossy J, Donovan-Peluso M, et al. Amplification of epidermal growth factor receptor gene in gliomas: histopathology and prognosis. J Neuropathol Exp Neurol. 1992;51:84–90
  8. Cowley GP, Smith JA, Gusterson BA. Increased EGF receptors on human squamous carcinoma cell lines. Br J Cancer. 1986;53:223–229
  9. Hendler FJ, Ozanne BW. Human squamous cell lung cancers express increased epidermal growth factor receptors. J Clin Invest. 1984;74:647–651
  10. Woodruff JM, Kourea HP, Louis DN, et al. Schwannoma. In:  Kleihues P,  Cavenee WK editor. Tumours of the nervous system. Lyons, FR: IARC Press; 2000;p. 164–166
  11. Ling BC, Wu J, Miller SJ, et al. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell. 2005;7:65–75
  12. Nakagawa Y, Yoshida A, Numoto K, et al. Chromosomal imbalances in malignant peripheral nerve sheath tumor detected by metaphase and microarray comparative genomic hybridization. Oncol Rep. 2006;15:297–303
  13. Li H, Velasco-Miguel S, Vass WC, et al. Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the NF1:p53 mouse tumor model. Cancer Res. 2002;62:4507–4513
  14. Kersting C, Packeisen J, Leidinger B, et al. Pitfalls in immunohistochemical assessment of EGFR expression in soft tissue sarcomas. J Clin Pathol. 2006;59:585–590
  15. Perry A, Kunz SN, Fuller CE, et al. Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. J Neuropathol Exp Neurol. 2002;61:702–709
  16. DeClue JE, Heffelfinger S, Benvenuto G, et al. Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models. J Clin Invest. 2000;105:1233–1241
  17. Sturgis EM, Woll SS, Aydin F, et al. Epidermal growth factor receptor expression by acoustic neuromas. Laryngoscope. 1996;106:457–462
  18. Kersting C, Packeisen J, Leidinger B, et al. Pitfalls in immunohistochemical assessment of EGFR expression in soft tissue sarcomas. J Clin Pathol. 2006;59:585–590

PII: S1092-9134(06)00131-6

doi: 10.1016/j.anndiagpath.2006.09.007

Annals of Diagnostic Pathology
Volume 11, Issue 5 , Pages 326-329 , October 2007

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