Annals of Diagnostic Pathology
Volume 12, Issue 4 , Pages 293-295, August 2008

Angiomyolipoma of the anterior mediastinum

  • Carrie S. Knight, MD

      Affiliations

    • Department of Pathology, University of Alabama School of Medicine, Birmingham, AL, USA
    • ,
  • Robert J. Cerfolio, MD

      Affiliations

    • Department of Surgery, University of Alabama School of Medicine, Birmingham, AL, USA
    • ,
  • Thomas S. Winokur, MD

      Affiliations

    • Department of Pathology, University of Alabama School of Medicine, Birmingham, AL, USA
    • Corresponding Author InformationCorresponding author. Department of Pathology, NP3541, University of Alabama at Birmingham, Birmingham, AL 35249, USA. Tel.: +1 205 975 8880; fax: +1 205 975 5242.

published online 14 September 2007.

Abstract 

Angiomyolipoma is a benign tumor composed of varying proportions of smooth muscle cells, blood vessels, and adipose tissue that most commonly occurs in the kidney. Sporadic lesions and lesions arising in the setting of the tuberous sclerosis complex have been reported in extrarenal sites. We present the case of an incidentally discovered angiomyolipoma in the anterior mediastinum. Thymoma was suspected clinically, and the lesion was composed mainly of spindled-to-epithelioid cells arranged in a histologic pattern reminiscent of hemangiopericytoma, a pattern that has been described in thymoma. Immunohistochemical stains revealed positivity for smooth muscle actin and HMB-45, revealing the expression of smooth muscle and melanocytic markers characteristic of angiomyolipoma and other lesions in the PEComa family.

Keywords: Angiomyolipoma, PEComa, Perivascular epithelioid cell, Mediastinum

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PII: S1092-9134(06)00165-1

doi:10.1016/j.anndiagpath.2006.12.007

Annals of Diagnostic Pathology
Volume 12, Issue 4 , Pages 293-295, August 2008

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