Annals of Diagnostic Pathology
Volume 12, Issue 1 , Pages 1-3, February 2008

Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin

  • Lars-Christian Horn, MD, PhD

      Affiliations

    • Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Division of Gynecologic Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Corresponding Author InformationCorresponding author. Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany. Tel.: + 49 341 97.150.46; fax: +49 341 97 150 09.
    • ,
  • Claudia Hänel, TA

      Affiliations

    • Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Erika Bartholdt, MD

      Affiliations

    • Institute of Pathology, HELIOS Clinics, D-8289 Aue, Germany
    • ,
  • Jochen Dietel, MD

      Affiliations

    • Department of Obstetrics and Gynecology, HELIOS Hospital, D-8289 Aue, Germany

published online 03 October 2007.

Abstract 

The pathogenesis of mixed endometrial adenocarcinoma with trophoblastic differentiation is quite unclear at times. The present study examines a serous carcinoma with choriocarcinomatous differentiation. p53 staining was seen in the serous component and the cytotrophoblastic cells of the choriocarcinomatous component, but not in the syncytiotrophoblastic cells. p53 mutational analysis showed a heterozygotic mutation at exon 8 for the choriocarcinomatous component and a homozygote deletion at exon 7 for the serous component. These alterations suggest that the multidirectional tumor differentiation might occur from a common stem cell in these malignancies.

Keywords: Choriocarcinoma, Endometrial adenocarcinoma, p53, Mutation, Trophoblastic disease

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PII: S1092-9134(07)00010-X

doi:10.1016/j.anndiagpath.2007.01.004

Annals of Diagnostic Pathology
Volume 12, Issue 1 , Pages 1-3, February 2008

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