Annals of Diagnostic Pathology
Volume 12, Issue 1 , Pages 1-3 , February 2008

Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin

  • Lars-Christian Horn, MD, PhD

      Affiliations

    • Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Division of Gynecologic Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • Corresponding Author InformationCorresponding author. Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany. Tel.: + 49 341 97.150.46; fax: +49 341 97 150 09.
    • ,
  • Claudia Hänel, TA

      Affiliations

    • Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Erika Bartholdt, MD

      Affiliations

    • Institute of Pathology, HELIOS Clinics, D-8289 Aue, Germany
    • ,
  • Jochen Dietel, MD

      Affiliations

    • Department of Obstetrics and Gynecology, HELIOS Hospital, D-8289 Aue, Germany

References 

  1. Matis-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, et al. Molecular pathology of endometrial hyperplasia and carcinoma. Hum Pathol. 2001;32:569–577
  2. Hoffmann K, Nekhlyudov L, Deligdisch L. Endometrial carcinoma in elderly women. Gynecol Oncol. 1995;58:198–201
  3. Savage J, Surby W, Okagaki T. Adenocarcinoma of the endometrium with trophoblastic differentiation and metastases as a choriocarcinoma: a case report. Gynecol Oncol. 1987;26:257–262
  4. Bradley CS, Benjamin I, Wheeler JE, Rubin SC. Endometrial adenocarcinoma with trophoblastic differentiation. Gyneol Oncol. 1998;69:74–77
  5. Horn LC, Fischer U, Hänel C, Kuhn H, Raptis G, Bilek K. p53 in surgically treated and pathologically staged cervical cancer: correlation with local tumor progression, but not with lymphatic spread. Pathol Res Pract. 2001;197:605–609
  6. Guarino M, Giordano F, Pallotti F, Polizzotti G, Tricomi P, Cristofor E. Malignant mixed Müllerian tumor of the uterus. Features favoring its origin from a common cell clone and an epithelial-to-mesenchymal transformation mechanism of histogenesis. Tumori. 1998;84:391–397
  7. Nguyen CP, Levi AW, Montz FJ, Bristow RE. Coexistent choriocarcinoma and malignant mixed mesodermal tumor of the uterus. Gynecol Oncol. 2000;79:499–503
  8. Cheung AN, Shen DH, Khoo US, Chiu MP, Tin VP, Chung LP, et al. Immunohistochemical and mutational analysis of p53 tumor suppressor gene in gestational trophoblastic disease: correlation with mdm2, proliferation index and clinicopathologic features. Int J Gynecol Cancer. 1999;9:123–130

PII: S1092-9134(07)00010-X

doi: 10.1016/j.anndiagpath.2007.01.004

Annals of Diagnostic Pathology
Volume 12, Issue 1 , Pages 1-3 , February 2008

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