Annals of Diagnostic Pathology
Volume 11, Issue 6 , Pages 433-439 , December 2007

Inflammatory myofibroblastic tumor of larynx: a benign lesion with variable morphological spectrum

  • Muhammud T. Idrees, MD

      Affiliations

    • Department of Pathology, The Mount Sinai School of Medicine, New York, NY 10029, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 241 9146.
    • ,
  • Youming Huan, MD

      Affiliations

    • Department of Pathology, The Mount Sinai School of Medicine, New York, NY 10029, USA
    • ,
  • Peak Woo, MD

      Affiliations

    • Department of Orolaryngology, The Mount Sinai School of Medicine, New York, NY 10029, USA
    • ,
  • Beverly Y. Wang, MD

      Affiliations

    • Department of Pathology, Tisch Hospital, New York University, NY 10016, USA

References 

  1. Wenig BM, Devaney K, Bisceglia M. Inflammatory myofibroblastic tumor of the larynx. A clinicopathologic study of eight cases simulating a malignant spindle cell neoplasm. Cancer. 1995;76:2217–2229
  2. Corsi A, Ciofalo A, Leonardi M, Zambetti G, Bosman C. Recurrent inflammatory myofibroblastic tumor of the glottis mimicking malignancy. Am J Otolaryngol. 1997;18:121–1266
  3. Kendall CH, Johnston MN. Pseudo-malignant laryngeal nodule (inflammatory myofibroblastic tumour). Histopathology. 1998;32:286–287
  4. Matsumoto T, Nishiya M, Ichikawa G, Fujii H. Leiomyoma with atypical cells (atypical leiomyoma) in the larynx. Histopathology. 1999;34:532–536
  5. Munoz A, Villafruela M. Inflammatory pseudotumor of the larynx: MR findings in a child. Pediatr Radiol. 2001;31:459–460
  6. Martinez S, Bosch R, Pardo J, Salvado MT, Alvaro T. Inflammatory myofibroblastic tumour of larynx. J Laryngol Otol. 2001;115:140–142
  7. Ereno C, Lopez JI, Grande J, Santaolalla F, Bilbao FJ. Inflammatory myofibroblastic tumour of the larynx. J Laryngol Otol. 2001;115:856–858
  8. Hanna SJ, Blenke E, Sharma R, Knight LC. Laryngeal inflammatory pseudotumour: an unusual cause of airway obstruction. Int J Pediatr Otorhinolaryngol. 2005;69:1253–1255
  9. Guilemany JM, Alos L, Alobid I, Bernal-Sprekelsen M, Cardesa A. Inflammatory myofibroblastic tumor in the larynx: clinicopathologic features and histogenesis. Acta Otolaryngol. 2005;125:215–219
  10. Alaani A, Hogg R, Warfield AT, Olliff J, Jennings C. Air bag injury as a cause of inflammatory myofibroblastic pseudotumour of the subglottic larynx progressing to myositis ossificans. Acta Otolaryngol. 2005;125:674–677
  11. Rodrigues M, Taylor RJ, Sun CC, Wolf JS. Inflammatory myofibroblastic tumor of the larynx in a 2-year-old male. ORL J Otorhinolaryngol Relat Spec. 2005;67:101–105
  12. Suh SI, Seol HY, Lee JH, Lee YH, Kim TK, Lee NJ, et al. Inflammatory myofibroblastic tumor of the larynx. Head Neck. 2006;28:369–372
  13. Volker HU, Scheich M, Holler S et al. Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor—report of two cases with similar morphology.
  14. Bellezza G, Cavaliere A, Del Sordo R, Sidoni A. Inflammatory myofibroblastic tumor of the larynx with anaplastic lymphoma kinase (ALK) protein overexpression. A case report. Tumori. 2006;92:449–451
  15. Zitsch RP, Pollak N, Loy TS. Management of inflammatory pseudotumor of the larynx. Otolaryngol Head Neck Surg. 2007;136:139–141
  16. Su LD, Atayde-Perez A, Sheldon S, Fletcher JA, Weiss SW. Inflammatory myofibroblastic tumor: cytogenetic evidence supporting clonal origin. Mod Pathol. 1998;11:364–368
  17. Coffin CM, Patel A, Perkins S, Elenitoba-Johnson KS, Perlman E, Griffin CA. ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol. 2001;14:569–576
  18. Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumour (inflammatory pseudotumour): a clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995;19:859–872
  19. MacGregor AR, Batsakis JG, El-Naggar AK. Myofibroblastoma of the larynx: a study of two cases. Head Neck. 2003;25:606–611
  20. Meis-Kindblom JM, Kjellstrom C, Kindblom LG. Inflammatory fibrosarcoma: update, reappraisal, and perspective on its place in the spectrum of inflammatory myofibroblastic tumors. Semin Diagn Pathol. 1998;15:133–143
  21. Arber DA, Kamel OW, van de Rijn M, Davis RE, Medeiros LJ, Jaffe ES, et al. Frequent presence of the Epstein-Barr virus in inflammatory pseudotumor. Hum Pathol. 1995;26:1093–1098
  22. Hakozaki Y, Katou M, Nakagawa K, Shirahama T, Matsumoto T. Improvement of inflammatory pseudotumor of the liver after nonsteroidal anti-inflammatory agent therapy. Am J Gastroenterol. 1993;88:1121–1122
  23. Jones MK, Wang HT, Peskar BM, et al. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and healing. Nat Med. 1999;5:1418–1423
  24. Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, et al. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. Genes Chromosomes Cancer. 2002;34:354–362
  25. Gomez-Roman JJ, Sanchez-Velasco P, Ocejo-Vinyals G, et al. Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). Am J Surg Pathol. 2001;25:624
  26. Gomez-Roman JJ, Ocejo-Vinyals G, Sanchez-Velasco P, Nieto EH, Leyva-Cobian F, Val-Bernal JF. Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor). Lab Invest. 2000;80:1121–1126
  27. Kutok JL, Pinkus GS, Dorfman DM, Fletcher CD. Inflammatory pseudotumor of lymph node and spleen: an entity biologically distinct from inflammatory myofibroblastic tumor. Hum Pathol. 2001;32:1382–1387
  28. Mergan F, Jaubert F, Sauvat F, et al. Inflammatory myofibroblastic tumor in children: clinical review with anaplastic lymphoma kinase, Epstein-Barr virus, and human herpesvirus 8 detection analysis. J Pediatr Surg. 2005;40:1581–1586
  29. Yamamoto H, Kohashi K, Oda Y. Absence of human herpesvirus-8 and Epstein-Barr virus in inflammatory myofibroblastic tumor with anaplastic large cell lymphoma kinase fusion gene. Pathol Int. 2006;56:584–590

PII: S1092-9134(07)00053-6

doi: 10.1016/j.anndiagpath.2007.04.004

Annals of Diagnostic Pathology
Volume 11, Issue 6 , Pages 433-439 , December 2007

Article Tools

* Image Usage & Resolution