Annals of Diagnostic Pathology
Volume 12, Issue 2 , Pages 90-97 , April 2008

Clinicomorphologic features of a series of 10 cases of malignant triton tumors diagnosed over 10 years at a tertiary cancer hospital in Mumbai, India

  • Bharat Rekhi, MD, DNB, MIAC

      Affiliations

    • Department of Pathology, Tata Memorial Hospital, Mumbai 400012, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 22 416 1413x7269; fax: +91 22 4146973.
    • ,
  • Nirmala A. Jambhekar, MD, DPB

      Affiliations

    • Department of Pathology, Tata Memorial Hospital, Mumbai 400012, India
    • ,
  • Ajay Puri, MS

      Affiliations

    • Department of Orthopedic Surgical Oncology, Tata Memorial Hospital, Mumbai 400012, India
    • ,
  • Manish Agrawal, MS, DNB

      Affiliations

    • Department of Orthopedic Surgical Oncology, Tata Memorial Hospital, Mumbai 400012, India
    • ,
  • Roshan F. Chinoy, MD, DPB

      Affiliations

    • Department of Pathology, Tata Memorial Hospital, Mumbai 400012, India

References 

  1. Ducatman BS, Scheithauer B. Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer. 1984;54:1049–1057
  2. Masson P. Recklinghausen's neurofibromatosis. In: Sensory neuromas and motor neuromas, Libman anniversary. vol. 2:New York: International Press; 1932;p. 793–802
  3. Locatelli P. Formation des membres surnumeraires. C R Assoc Anat 20 em reunion Turin. 1925;20:279–282
  4. Masson P, Martin JF. Rhabdomyomes des nerfs. Bull Assoc Fr Cancer. 1938;27:751–767
  5. Woodruff JM, Chernik NL, Smith MC, Millet WB, et al. Peripheral nerve tumors with rhabdomyosarcomatous differentiation (malignant “Triton” tumors). Cancer. 1973;32:426–439
  6. Daimaru Y, Hashimoto H, Enjoji M. Malignant triton tumors: a clinicopathologic and immunohistochemical study of nine cases. Hum Pathol. 1984;15:768–778
  7. Brooks JS, Freeman M, Enterline HT. Malignant “Triton” tumours. Natural history and immunohistochemistry of nine new cases with literature review. Cancer. 1985;55:2543–2549
  8. Dewit L, Albus-Lutter CE, De Jong ASH, et al. Malignant schwannoma with a rhabdomyoblastic component, a so-called Triton tumor. Cancer. 1986;58:1350–1356
  9. Aldlyami E, Dramis A, Grimer RJ, et al. Malignant triton tumour of the thigh—a retrospective analysis of nine cases. Eur J Surg Oncol. 2006;31:1–3
  10. Weiss SV, Enzinger FM. Malignant tumours of peripheral nerves. In:  Weiss SV,  Goldblum R editor. Enzinger and Weiss's soft tissue tumours. 4th ed.. St Louis: CV Mosby; 2001;p. 1209–1263
  11. Taylor CR, Shi SR, Barr NJ, et al. Techniques of immunohistochemistry: principles, pitfalls, and standardization. In: Dabbs DJ, editor. Diagnostic immunohistochemistry. Ed 2. Philadelphia, PA: Churchill Livingstone; 2006.
  12. Guillou L, Coindre JM, Bonichon F, et al. Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol. 1997;15:350–362
  13. Bryan L, Lawrence W, Jeffrey ML. Neurofibroma and cellular neurofibroma with atypia: a report of 14 tumors. Am J Surg Pathol. 1997;21:1443–1449
  14. Masson P. In: Human tumors. Detroit: Wayne State University Press; 1970;p. 1107–1109
  15. Masui F, Yokoyama R, Soshi S, et al. A malignant peripheral nerve sheath tumor responding to chemotherapy. J Bone Joint Surg Br. 2004;86:113–115
  16. Zimmerman LE, Font RL, Anderson SR. Rhabdomyosarcomatous differentiation in malignant intraocular medulloepitheliomas. Cancer. 1972;30:817–830
  17. Basu TN, Gutmann DH, Fletcher JA, et al. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature. 1992;356(6371):713–715
  18. Strauss BL, Gutmann DH, Dehner LP, et al. Molecular analysis of malignant triton tumors. Hum Pathol. 1999;30:984–988
  19. Velagaleti GV, Miettinen M, Gatalica Z. Malignant peripheral nerve sheath tumour with rhabdomyoblastic differentiation (malignant triton tumour) with balanced t(7;9) (q11.2; p24) and unbalanced translocation der (16) t(1;16) (q23;q13). Cancer Genet Cytogenet. 2004;149:23–27
  20. Liapis H, Marley EF, Lin Y, et al. p53 and Ki-67 proliferating cell nuclear antigen in benign and malignant peripheral nerve sheath tumors in children. Pediatr Dev Pathol. 1999;2:377–384
  21. Kostler WJ, Amann G, Grunt TW, et al. Recurrent malignant Triton tumour: first report on a long time survivor. Oncol Rep. 2003;10:533–535

PII: S1092-9134(07)00059-7

doi: 10.1016/j.anndiagpath.2007.04.010

Annals of Diagnostic Pathology
Volume 12, Issue 2 , Pages 90-97 , April 2008

Article Tools

* Image Usage & Resolution