Annals of Diagnostic Pathology
Volume 12, Issue 6 , Pages 430-432 , December 2008

Morule-like features and tumor-associated lymphoid proliferation in gallbladder carcinoma

  • Yu Sakai, MD, PhD

      Affiliations

    • Department of Pathology, Japan Self Defense Forces Sapporo General Hospital, Hokkaido 062-8610, Japan
    • Corresponding Author InformationCorresponding author. Department of Pathology, Japan Self Defense Forces Sapporo General Hospital, 12-1-32 Hiragishi 1 Jo, Hokkaido 062-8610, Japan. Tel.: +81 11 831 0161; fax: +81 11 831 1015.
    • ,
  • Shinji Sano, MD

      Affiliations

    • Department of Surgery, Japan Self Defense Forces Sapporo General Hospital, Hokkaido 062-8610, Japan
    • ,
  • Hiroshi Koike, MD

      Affiliations

    • Department of Surgery, Japan Self Defense Forces Sapporo General Hospital, Hokkaido 062-8610, Japan

References 

  1. Dutra FR. Intraglandular morules of the endometrium. Am J Clin Pathol. 1959;31:60–65
  2. Makishi S, Kinjo T, Sawada S, et al. Morules and morule-like features associated with carcinomas in various organs: report with immunohistochemical and molecular studies. J Clin Pathol. 2006;59:95–100
  3. Sasaki A, Yokoyama S, Arita T, et al. Morules with biotin-containing optically clear nuclei in colonic tubular adenoma. Am J Surg Pathol. 1999;23:336–341
  4. Okamoto Y, Yokoyama S, Sasaki A, et al. Oncofetal expression of blood group–related antigen on morules in thyroid carcinoma. Pathol Int. 1996;46:867–873
  5. Fornelli A, Cavazza A, Cancellieri A, et al. Bronchioloalveolar carcinoma with nodular (“morule-like”) features. Virchows Arch. 2003;442:407–408
  6. Nishihara K, Yamaguchi K, Hashimoto H, et al. Tubular adenoma of the gallbladder with squamoid spindle cell metaplasia. Report of three cases with immunohistochemical study. Acta Pathol Jpn. 1991;41:41–45
  7. Takei K, Watanabe H, Itoi T, et al. p53 and Ki-67 immunoreactivity and nuclear morphometry of ‘carcinoma-in-adenoma’ and adenoma of the gall-bladder. Pathol Int. 1996;46:908–917
  8. Nakatani Y, Masudo K, Miyagi Y, et al. Abberant nuclear localization and gene mutation of β-catenin in low-grade adenocarcinoma of fetal lung type: up-regulation of the Wnt signaling pathway may be a common dominator for the development of tumors that form morules. Mod Pathol. 2002;15:617–624
  9. Gamallo C, Palacios J, Moreno G, et al. β-catenin expression pattern in stage I and II ovarian carcinomas. Relationship with β-catenin gene mutations, clinicopathological features, and clinical outcome. Am J Pathol. 1999;155:527–536
  10. Kimura Y, Kashima K, Daa T, et al. Biotin-rich intranuclear inclusions in morule-lacking adenocarcinoma of the gallbladder: a new category of “neoplastic/non-morular” lesions. Virchows Arch. 2005;446:194–199
  11. Kijima H, Suto A, Takeshita T, et al. Gallbladder carcinoma with lymphoid stroma. A case report with immunohistochemical analyses. J Clin Gastroenterol. 1999;28:256–258

PII: S1092-9134(07)00084-6

doi: 10.1016/j.anndiagpath.2007.05.001

Annals of Diagnostic Pathology
Volume 12, Issue 6 , Pages 430-432 , December 2008

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