Annals of Diagnostic Pathology
Volume 13, Issue 2 , Pages 119-123, April 2009

Clinical features and differential diagnoses of solitary extramedullary plasmacytoma of the thyroid: a case report

  • Alfredo Avila, MD

      Affiliations

    • Department of Pathology, Hospital Angeles del Carmen, Guadalajara 44670, Jalisco, Mexico
    • ,
  • Alvaro Villalpando, MD

      Affiliations

    • Department of Pathology, Hospital IMSS, Mazatlán, Sinaloa 82019, Mexico
    • ,
  • Guillermo Montoya, MD

      Affiliations

    • Department of Oncologic Surgery, Hospital Angeles del Carmen, Guadalajara 44670, Jalisco, Mexico
    • ,
  • Mario A. Luna, MD

      Affiliations

    • Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 713 792 3138; fax: +1 713 745 4427.

published online 08 October 2007.

Abstract 

A 40-year-old woman presented with a rapidly enlarging palpable thyroid mass. The patient underwent a total thyrodectomy. The tumor fulfilled the criteria of primary solitary extramedullary plasmacytoma (SEP), including cellular expression of the CD138 and lambda light chain antibodies. Solitary extramedullary plasmacytoma of the thyroid occurs most commonly in patients with Hashimoto thyroiditis and must be distinguished from involvement of thyroid in multiple myeloma, inflammatory pseudotumor plasma cell variant, mucosa-associated lymphoid tissue lymphoma, and medullary carcinoma. The distinction is determined on the basis of histologic findings, immunohistochemical analysis, and other laboratory tests. Currently, no standard treatment exists for this entity. In this report, we discuss the differential diagnosis of SEP of the thyroid and the clinical features observed in this case.

Keywords: Thyroid, Solitary, Extramedullary, Plasmacytoma

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PII: S1092-9134(07)00120-7

doi:10.1016/j.anndiagpath.2007.07.003

Annals of Diagnostic Pathology
Volume 13, Issue 2 , Pages 119-123, April 2009

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