Annals of Diagnostic Pathology
Volume 12, Issue 4 , Pages 239-248 , August 2008

Clinicopathologic profile of 470 giant cell tumors of bone from a cancer hospital in western India

  • R. Gupta, MD, DNB

      Affiliations

    • Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400012, India
  • ,
  • V. Seethalakshmi, MD

      Affiliations

    • Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400012, India
  • ,
  • N.A. Jambhekar, MD, DPB

      Affiliations

    • Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400012, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 22 24177000x7260; fax: +91 22 24146937, 22 24125556.
  • ,
  • S. Prabhudesai, MD
  • ,
  • N. Merchant, MD

      Affiliations

    • Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400012, India
  • ,
  • A. Puri, MS

      Affiliations

    • Department of Radiology, Tata Memorial Hospital, Parel, Mumbai 400012, India
  • ,
  • M. Agarwal, MS

      Affiliations

    • Department of Orthopedic Surgery, Tata Memorial Hospital, Parel, Mumbai 400012, India

References 

  1. Werner M. Giant cell tumour of bone: morphological, biological and histogenetical aspects. Int Orthop. 2006;30(6):484–489
  2. Huvos AG. Giant cell of bone. In: Bone tumors: diagnosis, treatment and prognosis. Philadelphia: WB Saunders; 1979;p. 265–291
  3. Eckardt JJ, Grogan TJ. Giant cell tumor of bone. Clin Orthop Relat Res. 1986;204:45–58
  4. SPSS for windows [computer program]. Version 14. Chicago, Illinois: SPSS Inc; 2006;
  5. Zheng MH, Robbins P, Xu J, Huang L, Wood DJ, Papadimitriou JM. The histogenesis of giant cell tumour of bone: a model of interaction between neoplastic cells and osteoclasts. Histol Histopathol. 2001;16(1):297–307
  6. Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987;69(1):106–114
  7. Chitale AR, Jambhekar NA. Report of bone registry, 1970-82 (A twelve year study). Indian J Pathol Microbiol. 1987;30:201–218
  8. Dahlin DC, Cupps RE, Johnson EW. Giant cell tumor, A study of 195 cases. Cancer. 1970;25:1061–1070
  9. Goldenberg RR, Crawford C, Bonfiglio M. Giant cell tumor of bone. J Bone Joint Surg. 1970;52-A:619–664
  10. Mcdonald DJ, Sim FH, Mcleod RA, Dahlin DC. Giant cell tumor of bone. J Bone Joint Surg. 1986;68-A:235–242
  11. Sung HW, Kuo DP, Shu WP, Chai YB, Liu CC, Li SM. Giant cell tumor of bone—analysis of two hundred and eight cases in Chinese patients. J Bone Joint Surg. 1982;64-A:751–760
  12. Mirra JM, Picci P, Gold R. In Bone tumors: clinical, radiologic and pathologic correlation. Lea and Febiger, USA: p. 941, 589-617, 1267-1309, 1989.
  13. Reid R, Banerjee SS, Sciot R. Giant cell tumor. In:  Fletcher CDM,  Unni KK,  Mertens F editor. Pathology and Genetics of tumors of soft tissue and bone. Lyon: IARC press; 2001;p. 306–308
  14. Dahlin DC. Giant cell tumor (Osteoclastoma): bone tumors, 3rd edition, Springfield IL, Charles C Thomas, 1978, 99-115, 228-295.
  15. Larsson SE, Lorentzon R, Boquist L. Giant cell tumors of bone. A demographic, clinical and histopathological study of all cases recorded in the Swedish Cancer Registry for the year 1958 through 1968. J Bone Joint Surg. 1979;57-A:167–173
  16. Nayar M, Chandra M, Saxena HMK, Dass DC. Bone tumors and tumor like conditions—a retrospective study. Indian J Cancer. 1979;16:18–25
  17. Reddy CRRM, Rao PS, Rajakumari K. Giant cell tumor of bone in South India. J Bone Joint Surg. 1974;56-A:617–619
  18. Morgan JD, Eady JL. Giant cell tumor and the skeletally immature patient. J South Orthop Assoc. 1999;8(4):275–284
  19. Picci P, Manfrini M, Zucchi V, Gherlinzoni F, Rock M, Bertoni F, et al. Giant cell tumor of bone in skeletally immature patients. J Bone Joint Surg. 1983;65-A:486–490
  20. Tuli SM, Gupta IM, Mishra RK. A clinicopathological appraisal of treatment, complications and recurrence in giant cell tumor of bone Indian. J Cancer. 1984;21:14–22
  21. McGrath PJ. Giant cell tumor of bone: an analysis of fifty two cases. J Bone Joint Surg. 1972;54-B:216–229
  22. Kirby EJ, Buchalter JS, Kastenbaum , Kenan S, Kummer FJ, Lewis MM. CO2 laser cauterisation of giant cell tumor margins. Clin Orthop Relat Res. 1990;253:231–239
  23. Bridge JA, Neff JR, Bhatia PS, Sanger KG, Murphy MD. Cytogenetic findings and biologic behavior of giant cell tumor of bone. Cancer. 1990;65:2697–2703
  24. Gitelis S, Wilkins R, Conrad EU. Benign bone tumors. J Bone Joint Surg. 1995;77-A:1756–1781
  25. Sim FH, Dahlin DC, Beabout JW. Multicentric giant cell tumor of bone. J Bone Joint Surg. 1977;59-A:1052–1060
  26. Manaster BJ, Doyle AJ. Giant cell tumor of bone. Radiol Clin North Am. 1993;31:299–323
  27. Abhyankar SC, Johari AN, Baralay SB. Giant cell tumor of vertebral column. Indian J Pathol Microbiol. 1988;31:75–79
  28. Ayala AG, Raymond K, Ro JY, Carrasco H, Fanning CV, Murray JA. Needle biopsy of primary bone lesions: M.D. Anderson experience. Pathol Annu. 1989;24(1):219–251
  29. Fornasier VL, Protzner K, Zhang I, Mason L. The proognostic significance of histomorphometry and immmunohistochemistry of giant cell tumors of bone. Hum Pathol. 1996;27(8):754–760
  30. Martinez V, Sissons HA. Aneurysmal bone cyst: A review of 123 cases including primary lesions and those secondary to other bone pathology. Cancer. 1988;61:2291–2304
  31. Sanerkin NG. Malignancy, aggressiveness and recurrence in giant cell tumor of bone. Cancer. 1980;46:1641–1649
  32. Lichtenstein L. In: Bone tumors. 5th ed.. St. Louis, Mo; Mosby; 1977;p. 127–158
  33. Shigematsu K, Kobata Y, Yajima H, Kawamura K, Maegawa N, Takakura Y. Giant-cell tumors of the carpus. J Hand Surg [Am]. 2006;31(7):1214–1219
  34. Rock MG, Pritchard DJ, Unni KK. Metastases from histologically benign giant cell tumor of bone. J Bone Joint Surg. 1984;66-A:269–273
  35. Present DA, Bertoni F, Springfield D. Giant cell tumor of bone with pulmonary and lymph node metastases. Clin Orthop Relat Res. 1986;209:286–290
  36. Tyler W, Barrett T, Frassica F, MacCarthy E. Skin metastasis from conventional giant cell tumor of bone: conceptual significance. Skeletal Radiol. 2002;31(3):166–170
  37. Connell D, Munk PL, Lee MJ, O'Connell JX, Janzen D, Vu M, et al. Giant cell tumor of bone with selective metastases to mediastinal lymph nodes. Skeletal Radiol. 1998;27(6):341–345
  38. Alacacioglu A, Bengi G, Oztop I, Canda T, Balci P, Osma E, et al. Metastasis of giant cell tumor to the breast: case report and review of the literature. Tumori. 2006;92(4):351–353
  39. Maloney WJ, Vaughan LM, Jones HH, Ross J, Nagel DA. Benign metastasizing giant cell tumor of bone: A report of three cases and review of literature. Clin Orthop Relat Res. 1989;243:208–214
  40. Guo QC, Shen JN, Wang J, Huang G, Zou CY, Jin S, et al. Analysis of the factors affecting the recurrence of giant cell tumor of bone. Zhonghua Wai Ke Za Zhi. 2006;44(12):797–800
  41. Cheng JC, Johnston JO. Giant cell tumor of bone: Prognosis and treatment of pulmonary metastasis. Clin Orthop Relat Res. 1997;338:205–214
  42. Ladanyi M, Traganos F, Huvos AG. Benign metastasizing giant cell tumors of bone: A DNA flow cytometric study. Cancer. 1989;64:1521–1526
  43. Kay RM, Eckardt JJ, Seeger LL, Mirra JM, Hak DJ. Pulmonary metastasis of benign giant cell tumor of bone. Six histologically confirmed cases, including one of spontaneous regression. Clin Orthop. 1994;302:219–230
  44. Rock M. Curettage of giant cell tumor of bone. Factors influencing local recurrences and metastases. In: Proceedings of combined European Musculoskeletal Oncology Society and Musculoskeletal Tumor Society Meeting. Bologna, Italy: Capelli Editore; 1989;p. 204–205
  45. Hoch B, Inwards C, Sundaram M, Rosenberg AE. Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty cases. J Bone Joint Surg Am. 2006;88(9):1998–2008
  46. Sakkers RJB, Van der Heul RO, Krool HM, Taminiau AHM, Hogendorn PCW. Late malignant transformation of a benign giant-cell tumor of bone. J Bone Joint Surg. 1997;79-A:259–262
  47. Bennett J, Marcus RB, Million RR, Enneking WF. Radiation therapy for giant cell tumor bone. Int J Radiat Oncol Biol Phys. 1993;26:299–304
  48. Soman CS, Talwalkar GV. Histopathological study of radiated giant cell tumor of the bone. Indian J Cancer. 1977;14:241–248

PII: S1092-9134(07)00155-4

doi: 10.1016/j.anndiagpath.2007.09.002

Annals of Diagnostic Pathology
Volume 12, Issue 4 , Pages 239-248 , August 2008