Annals of Diagnostic Pathology
Volume 13, Issue 2 , Pages 132-139 , April 2009

Pseudomembranous disease (ligneous inflammation) of the female genital tract, peritoneum, gingiva, and paranasal sinuses associated with plasminogen deficiency

  • Angela C. Chi, DMD

      Affiliations

    • Division of Oral Pathology, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 843 792 3677; fax: +1 843 792 3697.
    • ,
  • Elizabeth Prichard, MD

      Affiliations

    • Department of Pathology, Northeast Medical Center, Concord, NC, USA
    • ,
  • Mary S. Richardson, DDS, MD

      Affiliations

    • Surgical Pathology, College of Medicine, Medical University of South Carolina, SC, USA
    • ,
  • Kenneth P. Rasenberger, DMD

      Affiliations

    • Private Practice, Charlotte, NC, USA
    • ,
  • Dwight R. Weathers, DDS, MSD

      Affiliations

    • Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA, USA
    • ,
  • Brad W. Neville, DDS

      Affiliations

    • Division of Oral Pathology, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA

References 

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  4. Schuster V, Seidenspinner S, Zeitler P, Escher C, Pleyer U, Bernauer W, et al. Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis. Blood. 1999;15:3457–3466
  5. Schott D, Dempfle CE, Beck P, Liermann A, Mohr-Pennert A, Goldner M, et al. Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency. N Engl J Med. 2005;339:1679–1685
  6. Tefs K, Gueorguieva M, Klammt J, Allen CM, Aktas D, Anlar FY, et al. Molecular and clinical spectrum of type I plasminogen deficiency: a series of 50 patients. Blood. 2006;108:3021–3026
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  8. Drew AF, Kaufman AH, Kombrinck KW, Danton MJ, Daugherty CC, Degen JL, et al. Ligneous conjunctivitis in plasminogen-deficient mice. Blood. 1998;91:1616–1624
  9. Buck DC, Ridley CM. Ligneous conjunctivitis involving the cervix. Case report. Br J Obstet Gynaecol. 1990;97:193
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  19. Çiftçi E, Ince E, Akar N, Dogru Ü, Tafs K, Schuster V. Ligneous conjunctivitis, hydrocephalus, hydrocele, and pulmonary involvement in a child with homozygous type I plasminogen deficiency. Eur J Pediatr. 2003;162:462–465
  20. Mingers AM, Philapitsch A, Zeitler P, Schuster V, Schwarz HP, Kreth HW. Human homozygous type I plasminogen deficiency and ligneous conjunctivitis. Acta Pathol Microbiol Immunol Scand [A]. 1999;107:62–72
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  22. Ridley CM, Morgan H. Ligneous conjunctivitis involving the fallopian tube. Br J Obstet Gynaecol. 1993;100:791
  23. Chowdhury MMU, Blackford S, Williams S. Juvenile colloid milium associated with ligneous conjunctivitis: report of a case and review of the literature. Clin Dermatol. 2000;25:138–140
  24. Klebe S, Walkow T, Hartmann C, Pleyer U. Immunohistological findings in a patient with unusual late onset manifestation of ligneous conjunctivitis. Br J Ophthalmol. 1999;83:878–879
  25. Castellino FJ, Ploplis VA. Structure and function of the plasminogen/plasmin system. Thromb Haemost. 2005;93:647–654
  26. Mingers AM, Philapitsch A, Schwarz HP, Zeitler P, Kreth HW. Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis. Semin Thromb Hemost. 1998;24:605–612
  27. Rao SK, Biswas J, Rajagopal R, Sitalakshmi G, Padmanabhan P. Ligneous conjunctivitis: a clinicopathologic study of 3 cases. Int Ophthalmol. 1999;22:201–206
  28. Francois J, Victoria-Troncoso V. Treatment of ligneous conjunctivitis. Am J Ophthalmol. 1968;65:674–678
  29. De Cock R, Ficker LA, Dart JG, Garner A, Wright P. Topical heparin in the treatment of ligneous conjunctivitis. Ophthalmology. 1995;102:1654–1659
  30. Barabino S, Rolando M. Amniotic membrane transplantation in a case of ligneous conjunctivitis. Am J Ophthalmol. 2004;137:752–753
  31. Rodríguez-Ares MT, Abdulkader I, Blanco A, Touriño-Peralba R, Ruiz-Ponte C, Vega A, et al. Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. Virchows Arch. 2007;451:815–821
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  35. Mingers AM, Heimburger N, Zeitler P, Kreth HW, Schuster V. Homozygous type I plasminogen deficiency. Semin Thromb Hemost. 1997;23:259–269
  36. Sartori TM, Saggiorato G, Pellati D, Casonato A, Spiezia L, Pontara E, et al. Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis. Thromb Haemost. 2003;90:86–91

PII: S1092-9134(08)00024-5

doi: 10.1016/j.anndiagpath.2008.02.005

Annals of Diagnostic Pathology
Volume 13, Issue 2 , Pages 132-139 , April 2009

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