Granular cell tumor (Abrikossoff tumor) of the thyroid gland

Espinosa-de-los-Monteros-Franco, Vladimir A.; Martínez-Madrigal, Fernando; Ortiz-Hidalgo, Carlos

doi:10.1016/j.anndiagpath.2008.04.008

« Previous Next »Annals of Diagnostic Pathology
Volume 13, Issue 4 , Pages 269-271, August 2009

Granular cell tumor (Abrikossoff tumor) of the thyroid gland

Vladimir A. Espinosa-de-los-Monteros-Franco, MD
- Department of Pathology, The American British Cowdray Medical Center, Mexico D.F. 01120, Mexico
Fernando Martínez-Madrigal, MD
- Department of Pathology, Hospital Regional de Zona #1, IMSS, Morelia, Michoacán 58260, Mexico
- Department of Pathology, Universidad Michoacana de San Nicolás de Hidalgo School of Medicine, Morelia, Michoacán, Mexico
Carlos Ortiz-Hidalgo, MD
- Department of Pathology, The American British Cowdray Medical Center, Mexico D.F. 01120, Mexico
- Department of Tissue and Cell Biology, Universidad Panamericana School of Medicine, Mexico, D.F. 03810, Mexico
- Corresponding author. Department of Pathology, The American British Cowdray Medical Center, D.F. 01120, Mexico. Tel.: +52 55 5230 8171; fax: +52 55 5230 8171.

published online 07 July 2008.

Abstract

Only 4 cases of granular cell tumor of the thyroid have been previously reported in the English literature. We report herein the fifth case of this uncommon neoplasm and the first one affecting a male patient. The tumor was well circumscribed and located to the left thyroid lobe, near the isthmus. Histologically, the tumor was composed of large, rounded, granular eosinophilic cells that were immunohistochemically positive for S-100, calretinin, and PGP9.5 and negative for cytokeratin AE1-3, TTF-1, and thyroglobulin.

Keywords: Granular cell tumor, Thyroid