Annals of Diagnostic Pathology
Volume 13, Issue 2 , Pages 101-105 , April 2009

Macrofollicular variant of follicular thyroid carcinoma: a clinical, cytologic, morphologic, and image analysis study of a unique case

  • Massimo Bongiovanni, MD

      Affiliations

    • Department of Pathology, Geneva University Hospital, 1211 Geneva, Switzerland
    • Corresponding Author InformationCorresponding author. Tel.: +41 22 372 49 43; fax: +41 22 372 49 20.
    • ,
  • Magali Gremaud, MD

      Affiliations

    • Department of Pathology, Geneva University Hospital, 1211 Geneva, Switzerland
    • ,
  • Cecile Stephan Moulin, MD

      Affiliations

    • Department of Pathology, ADMED, 2000 Neuchatel, Switzerland
    • ,
  • Christof Scheidegger, MD

      Affiliations

    • Department of Pathology, Kantonsspital, 9007 St.Gallen, Switzerland
    • ,
  • Catherine Biton, PhD

      Affiliations

    • Department of Pathology, Geneva University Hospital, 1211 Geneva, Switzerland
    • ,
  • Sophie Clément, PhD

      Affiliations

    • Department of Pathology, Geneva University Hospital, 1211 Geneva, Switzerland

References 

  1. Sobrinho-Simoes M, Asa SL, Kroll TG, et al. Follicular carcinoma. In:  DeLellis RA,  Lloyd RV,  Heitz PU, et al. editor. Pathology and genetics of tumours of endocrine organs. World Health Organization classification of tumours. Lyon: IARC Press; 2004;p. 67–72
  2. LiVolsi V. Follicular lesion of the thyroid. In:  Bennington J editors. Surgical pathology of the thyroid. vol. 22:Philadelphia (Pa): Saunders; 1990;p. 173–212
  3. Rosai J, Carcangiu ML, Delellis RA. Follicular carcinoma. In:  Rosai J,  Sobin LH editor. Atlas of tumors pathology. Tumors of the Thyroid Gland. vol. 5:Washington, DC: Armed Forces Institute of Pathology; 1992;p. 49–63
  4. Fassina AS, Montesco MC, Ninfo V, et al. Histological evaluation of thyroid carcinomas: reproducibility of the “WHO” classification. Tumori. 1993;79:314–320
  5. Saxen E, Franssila K, Bjarnason O, et al. Observer variation in histologic classification of thyroid cancer. Acta Pathol Microbiol Scand [A]. 1978;86A:483–486
  6. Franc B, de la Salmoniere P, Lange F, et al. Interobserver and intraobserver reproducibility in the histopathology of follicular thyroid carcinoma. Hum Pathol. 2003;34:1092–1100
  7. Baloch ZW, Livolsi VA. Follicular-patterned lesions of the thyroid: the bane of the pathologist. Am J Clin Pathol. 2002;117:143–150
  8. Baloch ZW, LiVolsi VA. Our approach to follicular-patterned lesions of the thyroid. J Clin Pathol. 2007;60:244–250
  9. Albores-Saavedra J, Gould E, Vardaman C, et al. The macrofollicular variant of papillary thyroid carcinoma: a study of 17 cases. Hum Pathol. 1991;22:1195–1205
  10. Albores-Saavedra J, Housini I, Vuitch F, et al. Macrofollicular variant of papillary thyroid carcinoma with minor insular component. Cancer. 1997;80:1110–1116
  11. Clark DP, Faquin WC. Introduction and clinical aspects. In:  Rosenthal DL editors. Thyroid cytopathology. Baltimore (Md): Springer; 2005;p. 1–6
  12. Baloch ZW, Fleisher S, LiVolsi VA, et al. Diagnosis of “follicular neoplasm”: a gray zone in thyroid fine-needle aspiration cytology. Diagn Cytopathol. 2002;26:41–44
  13. Busseniers AE, Oertel YC. “Cellular adenomatoid nodules” of the thyroid: review of 219 fine-needle aspirates. Diagn Cytopathol. 1993;9:581–589
  14. Caraway NP, Sneige N, Samaan NA. Diagnostic pitfalls in thyroid fine-needle aspiration: a review of 394 cases. Diagn Cytopathol. 1993;9:345–350

PII: S1092-9134(08)00140-8

doi: 10.1016/j.anndiagpath.2008.12.009

Annals of Diagnostic Pathology
Volume 13, Issue 2 , Pages 101-105 , April 2009

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