Annals of Diagnostic Pathology
Volume 13, Issue 2 , Pages 89-95 , April 2009

Expression of immunoreactivity and genetic mutation in eosinophilic and ciliated metaplastic changes of endometrial glandular and stromal breakdown: cytodiagnostic implications

  • Keiko Shimizu, CT

      Affiliations

    • Department of Pathology, Saiseikai Noe Hospital, Imperial Gift Foundation Inc, Osaka 536-0002, Japan
    • Department of Medical Life Science, College of Life Science, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan
    • ,
  • Yoshiaki Norimatsu, PhD

      Affiliations

    • Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Ehime 791-2101, Japan
    • ,
  • Tadao K. Kobayashi, PhD

      Affiliations

    • Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc, Ritto, Shiga 520-3046, Japan
    • Corresponding Author InformationCorresponding author: Tel.: +81 77 552 1221; fax: +81 77 552 3942.
    • ,
  • Masami Sakurai, MD, PhD

      Affiliations

    • Japan Institute of Pathology Inc, Osaka 530-0014, Japan
    • ,
  • Seiko Ogura, CT

      Affiliations

    • Department of Pathology, Saiseikai Noe Hospital, Imperial Gift Foundation Inc, Osaka 536-0002, Japan
    • ,
  • Akihiko Yoshizawa, MD

      Affiliations

    • Department of Pathology, Kyoto University Hospital, Kyoto 606-8507, Japan
    • ,
  • Tomoyuki Miyamoto, CT

      Affiliations

    • Department of Cytopathology, Graduate School of Science and Industrial Technology, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan
    • ,
  • Yasuyuki Miyake, CT

      Affiliations

    • Department of Cytopathology, Graduate School of Science and Industrial Technology, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan
    • ,
  • Yatsuki Aratake, PhD

      Affiliations

    • Department of Medical Life Science, College of Life Science, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan
    • Department of Cytopathology, Graduate School of Science and Industrial Technology, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan
    • ,
  • Takuya Sakaguchi, PhD

      Affiliations

    • Department of Medical Life Science, College of Life Science, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan
    • Department of Cytopathology, Graduate School of Science and Industrial Technology, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan
    • ,
  • Eiji Ohno, PhD

      Affiliations

    • Department of Medical Life Science, College of Life Science, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan
    • Department of Cytopathology, Graduate School of Science and Industrial Technology, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan

References 

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  2. Ronnett BM, Kurman RJ. Precursor lesions of endometrial carcinoma. In:  Kurman RJ editors. Blaustein's pathology of the female genital tract. 5th ed.. New York: Springer-Verlag; 2001;p. 484–493
  3. Silverberg SG, Kurman RJ. Tumor-like lesions. In:  Rosai J editors. Tumor of the uterine corpus and gestational trophoblastic disease. Washington, DC: Armed Forces Institute of Pathology; 1992;p. 191–204
  4. Sherman ME, Mazur MT, Kurman RJ. Benign disease of the endometrium. In:  Kurman RJ editors. Blaustein's pathology of the female genital tract. 5th ed.. New York: Springer-Verlag; 2001;p. 431–439
  5. Kaku T, Silverberg SG, Tsukamoto N, Tsuruchi N, Kamura T, Saito T, et al. Association of endometrial epithelial metaplasia with endometrial carcinoma and hyperplasia in Japanese and American women. Int J Gynecol Pathol. 1993;12:297–300
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  9. Norimatsu Y, Shimizu K, Kobayashi TK, Moriya T, Kaku T, Tsukayama C, et al. Endometrial glandular and stromal breakdown, part 2: cytomorphology of papillary metaplastic changes. Diagn Cytopathol. 2006;34:665–669
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  15. Shih HC, Shiozawa T, Kato K, Imai T, Miyamoto T, Uchikawa T, et al. Immunohistochemical expression of cyclins, cyclin-dependent kinases, tumor-suppressor gene products, Ki-67, and sex steroid receptors in endometrial carcinoma: positive staining for cyclin A as a poor prognostic indicator. Human Pathol. 2003;34:471–478
  16. Quddus MR, Latkovich P, Castellani WJ, et al. Expression of cyclin D1 in normal, metaplastic, hyperplastic endometrium and endometrioid carcinoma suggests a role in endometrial carcinogenesis. Arch Pathol Lab Med. 2002;126:459–465
  17. Shiozawa T, Xin L, Nikaido T, Fujii S. Immunohistochemical detection of cyclin A with reference to p53 expression in endometrial endometrioid carcinomas. Int J Gynecol Pathol. 1997;16:348–353
  18. Ehrmann RL. Atypical cells and stromal breakdown two case reports. Acta Cytol. 1975;19:463–469
  19. Silver SA, Cheung ANY, Tavassoli FA. Oncocytic metaplasia and carcinoma of the endometrium: an immunohistochemical and ultrastructural study. Int J Gynecol Pathol. 1999;18:12–19
  20. Zaman SS, Mazur MT. Endometrial papillary syncytial change: a nonspecific alteration associated with active breakdown. Am J Clin Pathol. 1993;99:741–745
  21. Czernobilsky B, Katz Z, Lancet M, Gaton E. Endocervical type epithelium in endometrial carcinoma. Am J Surg Pathol. 1980;4:481–489
  22. Nucci MR, Prasad CJ, Crum CP, Mutter GL. Mucinous endometrial epithelial proliferations: a morphologic spectrum of changes with diverse clinical significance. Mod Pathol. 1999;12:1137–1142
  23. Ross JC, Eifel PJ, Cox RS. Primary mucinous adenocarcinoma of the endometrium. A clinicopathologic and histochemical study. Am J Surg Pathol. 1983;7:715–729
  24. Lehman MB, Hart WR. Simple and complex hyperplastic papillary proliferations of the endometrium: a clinicopathologic study of nine cases of apparently localized papillary lesions with fibrovascular stromal cores and epithelial metaplasia. Am J Surg Pathol. 2001;25:1347–1354

PII: S1092-9134(08)00142-1

doi: 10.1016/j.anndiagpath.2008.12.007

Annals of Diagnostic Pathology
Volume 13, Issue 2 , Pages 89-95 , April 2009

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