Annals of Diagnostic Pathology
Volume 13, Issue 4 , Pages 223-225 , August 2009

Histologic grading of invasive lobular carcinoma: does use of a 2-tiered nuclear grading system improve interobserver variability?

  • Amy L. Adams, MD

      Affiliations

    • Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 404 712 8804; fax: +1 404 727 2519.
    • ,
  • David C. Chhieng, MD

      Affiliations

    • Yale University School of Medicine, West Haven, CT 06520, USA
    • ,
  • Walter C. Bell, MD

      Affiliations

    • University of Alabama at Birmingham School of Medicine, Birmingham, AL 35233, USA
    • ,
  • Tom Winokur, MD

      Affiliations

    • University of Alabama at Birmingham School of Medicine, Birmingham, AL 35233, USA
    • ,
  • Omar Hameed, MBChB

      Affiliations

    • University of Alabama at Birmingham School of Medicine, Birmingham, AL 35233, USA

References 

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  2. Pereira H, Pinder SE, Sibbering DM, et al. Pathological prognostic factors in breast cancer. IV: should you be a typer or a grader? A comparative study of two histological prognostic features in operable breast carcinoma. Histopathology. 1995;27(3):219–226
  3. Haybittle JL, Blamey RW, Elston CW, et al. A prognostic index in primary breast cancer. Br J Cancer. 1982;45(3):361–366
  4. Balslev I, Axelsson CK, Zedeler K, Rasmussen BB, Carstensen B, Mouridsen HT. The Nottingham Prognostic Index applied to 9,149 patients from the studies of the Danish Breast Cancer Cooperative Group (DBCG). Breast Cancer Res Treat. 1994;32(3):281–290
  5. D'Eredita G, Giardina C, Martellotta M, Natale T, Ferrarese F. Prognostic factors in breast cancer: the predictive value of the Nottingham Prognostic Index in patients with a long-term follow-up that were treated in a single institution. Eur J Cancer. 2001;37(5):591–596
  6. Galea MH, Blamey RW, Elston CE, Ellis IO. The Nottingham Prognostic Index in primary breast cancer. Breast Cancer Res Treat. 1992;22(3):207–219
  7. Okugawa H, Yamamoto D, Uemura Y, et al. Prognostic factors in breast cancer: the value of the Nottingham Prognostic Index for patients treated in a single institution. Surg Today. 2005;35(11):907–911
  8. Adams AL, Li Y, Pfeifer JD, Hameed O. Nuclear grade and survival in invasive lobular carcinoma: a case series with long-term follow-up. Breast J (In Press).
  9. Bloom HJ, Richardson WW. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer. 1957;11(3):359–377
  10. Rakha EA, El-Sayed ME, Menon S, Green AR, Lee AH, Ellis IO. Histologic grading is an independent prognostic factor in invasive lobular carcinoma of the breast. Breast Cancer Res Treat. 2007;
  11. Sinha PS, Bendall S, Bates T. Does routine grading of invasive lobular cancer of the breast have the same prognostic significance as for ductal cancers?. Eur J Surg Oncol. 2000;26(8):733–737
  12. Talman ML, Jensen MB, Rank F. Invasive lobular breast cancer. Prognostic significance of histological malignancy grading. Acta Oncol. 2007;46(6):803–809
  13. Frierson HF, Wolber RA, Berean KW, et al. Interobserver reproducibility of the Nottingham modification of the Bloom and Richardson histologic grading scheme for infiltrating ductal carcinoma. Am J Clin Pathol. 1995;103(2):195–198
  14. Longacre TA, Ennis M, Quenneville LA, et al. Interobserver agreement and reproducibility in classification of invasive breast carcinoma: an NCI breast cancer family registry study. Mod Pathol. 2006;19(2):195–207
  15. Meyer JS, Alvarez C, Milikowski C, et al. Breast carcinoma malignancy grading by Bloom-Richardson system vs proliferation index: reproducibility of grade and advantages of proliferation index. Mod Pathol. 2005;18(8):1067–1078
  16. Sloane JP, Amendoeira I, Apostolikas N, et al. Consistency achieved by 23 European pathologists from 12 countries in diagnosing breast disease and reporting prognostic features of carcinomas. European Commission Working Group on Breast Screening Pathology. Virchows Arch. 1999;434(1):3–10

☆ This material was presented in part at the 98th Annual Meeting of the United States and Canadian Academy of Pathology in Boston, Mass, March 10, 2009.

PII: S1092-9134(09)00033-1

doi: 10.1016/j.anndiagpath.2009.03.004

Annals of Diagnostic Pathology
Volume 13, Issue 4 , Pages 223-225 , August 2009

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