Annals of Diagnostic Pathology
Volume 13, Issue 5 , Pages 291-296 , October 2009

Microscopic thrombi in glioblastoma multiforme do not predict the development of deep venous thrombosis

  • Nicholas F. Prayson

      Affiliations

    • Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    • ,
  • Lilyana Angelov, MD

      Affiliations

    • Brain Tumor and Neuro-Oncology Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    • ,
  • Richard A. Prayson, MD

      Affiliations

    • Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 216 444 8805; fax: +1 216 445 3707.

References 

  1. Falanga A, Zacharski L. Deep vein thrombosis in cancer: the scale of the problem and approaches to management. Ann Oncol. 2005;16:696–701
  2. Otten HMMB, Prins MH, Smorenburg SM, Hutten BA. Risk assessment and prophylaxis of venous thromboembolism in non-surgical patients: cancer as a risk factor. Haemostasis. 2000;30(Suppl 2):72–76
  3. Kumar K, Tang KK, Thomas J, Chumpon C. Is postoperative deep vein thrombosis a problem in neurosurgical patients with brain tumours in Singapore?. Singapore Med J. 2002;43:345–359
  4. Walsh DC, Kakkar AK. Thromboembolism in brain tumors. Curr Opin Pulm Med. 2001;7:326–331
  5. Shet A, Schorer AE, Kuskowski MA. Venous thromboembolism is common but does not alter survival in glioblastoma multiforme. Proc Am Soc Clin Oncol. 2003;[abstr 432]
  6. Kessler CM. Management of venous thromboembolism in cancer patients: challenges in a high-risk population. In:  Tapson VF editors. Am J Med Monograph: Treatment of Venous Thromboembolism. 2008;p. 21–29
  7. Rickles FR, Edwards RL, Barb C, et al. Abnormalities of blood coagulation in patients with cancer: fibrinopeptide a generation and tumour growth. Cancer. 1983;51:301–307
  8. Zacharski LR, Wojitukiewicz MZ, Constantini V, et al. Pathways of coagulation/fibrinolysis activation in malignancy. Sem Thromb Hemostasis. 1992;18:104–116
  9. Tehrani M, Friedman TM, Olson JJ, Brat DJ. Intravascular thrombosis in central nervous system malignancies: a potential role in astrocytoma progression to glioblastoma. Brain Pathol. 2008;18:164–171
  10. Kleihues P, Burger PC, Aldape KD, et al. Glioblastoma. In:  Louis DN,  Ohgaki H,  Wiestler OD,  Cavenne WK editor. WHO Classification of Tumours of the Central Nervous System. Lyon, FR: IARC Press; 2007;p. 33–49
  11. Raza SM, Lang FF, Aggarwal BB, Fuller GN, Wildrick DM, Sawaya R. Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis. Neurosurgery. 2002;51:2–12
  12. Brat DJ, Castellano-Sanchez A, Hunter SA, Pecot M, Cohen C, Hammond EH, et al. Pseudopalisdades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res. 2004;64:920–927
  13. Plate KH. Mechanics of angiogenesis in the brain. J Neuropathol Exp Neurol. 1999;58:313–320
  14. Shwacki D, Itin A, Soffer D, et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1999;359:843–845
  15. Takano S, Yoshii Y, Kondo S, et al. Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res. 1996;56:2185–2190
  16. Plate KH, Breier G, Weich HA, et al. Vascular endothelial growth factor and glioma angiogenesis coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanism. Int J Cancer. 1994;59:520–529
  17. Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL. Expression of hypoxia - inducible factor 1α in brain tumors. Association with angiogenesis, invasion and progression. Cancer. 2000;88:2606–2618
  18. Sawaya R, Ramo OJ, Shi MG, Mandipur G. Biological significance of tissue plasminogen activator content in brain tumors. J Neurosurg. 1991;74:480–486
  19. Sawaya R, Yamamoto M, Ramo OJ, Shi ML, Rayford A, Rao JS. Plasminogen activator inhibitor-1 in brain tumors: relation to malignancy and necrosis. Neurosurgery. 1995;36:375–380
  20. Guan M, Jin J, Su B, Liu WW, Lu Y. Tissue factor expression and angiogenesis in human glioma. Clin Bioch. 2002;35:321–325
  21. Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG, Brat DJ. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res. 2005;65:1406–1413
  22. Pong Y, Durden DL, Van Meir EG, Brat DJ. Pseudopalisading necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol. 2006;65:529–539

PII: S1092-9134(09)00056-2

doi: 10.1016/j.anndiagpath.2009.05.002

Annals of Diagnostic Pathology
Volume 13, Issue 5 , Pages 291-296 , October 2009

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