Annals of Diagnostic Pathology
Volume 13, Issue 5 , Pages 303-307 , October 2009

Nucleoporin 88 expression in normal and neoplastic squamous epithelia of the uterine cervix

  • Hermann Brustmann, MD, PhD

      Affiliations

    • Department of Pathology, Landesklinikum Thermenregion, A-2340 Moedling, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 2236 204 451; fax: +43 2236 204 461.
    • ,
  • Martina Hager, MD

      Affiliations

    • Department of Pathology, Paracelsus Medical University (PMU), A-5020 Salzburg, Austria

References 

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  2. Gould VE, Martinez N, Orucevic A, et al. A novel, nuclear pore- associated, widely distributed molecule overexpressed in oncogenesis and development. Am J Pathol. 2000;157:1605–1613
  3. Martinez N, Alonso A, Moragues MD, et al. The nuclear pore complex protein Nup88 is overexpressed in tumor cells. Cancer Res. 1999;59:5408–5411
  4. Clifford G, Franceschi S, Diaz M, et al. HPV type- distribution in women with and without cervical neoplastic disease. Vaccine. 2006;24S3:S3.26–S3.34
  5. Kurman RJ, Norris HJ, Wilkinson EJ. Tumors of the cervix. In:  Rosal J editors. Atlas of tumor pathology. Tumors of the cervix, vagina, and vulva. Washington, DC: Armed Forces Institute of Pathology; 1992;p. 30–56
  6. Remmele W, Schicketanz KH. Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer. Computer-assisted image analysis (OIC score) vs. subjective grading (IRS). Pathol Res Pract. 1993;189:862–866
  7. Kodiha M, Tran D, Qian DC, et al. Oxidative stress mislocalizes and retains transport factor importin-α and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes. Biochim Biophys Acta. 2008;1783:405–418
  8. Hutten S, Kehlenbach RH. CRM1-mediated nuclear export: to the pore and beyond. Mol Cell Biol. 2006;26:6772–6785
  9. Liu HL, Chen Y, Cui GH, et al. Deguelin regulates nuclear pore proteins Nup98 and Nup88 in U937 cells in vitro. Acta Pharmacol Sin. 2005;26:1265–1273
  10. Takahashi N, van Kilsdonk JW, Ostendorf B, et al. Tumor marker nucleoporin 88kDa regulates nucleocytoplasmic transport of NF-kappaB. Biochem Biophys Res Commun. 2008;374:424–430
  11. Schneider J, Linares R, Martínez-Arribas F, et al. Developing chick embryos express a protein which shares homology with the nuclear pore complex protein Nup88 present in human tumors. Int J Dev Biol. 2004;48:339–342
  12. Agudo D, Gómez-Esquer F, Martinez-Arribas F, et al. Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer. Int J Cancer. 2004;109:717–720
  13. Emterling A, Skoglund J, Arbman G, et al. Clinicopathological significance of Nup88 expression in patients with colorectal cancer. Oncology. 2003;64:361–369
  14. Zhang H, Schneider J, Rosdahl I. Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells. Int J Oncol. 2002;21:43–48
  15. Zhang ZY, Zhao ZR, Jiang L, et al. Nup88 expression in normal mucosa, adenoma, primary adenocarcinoma and lymph node metastasis in the colorectum. Tumour Biol. 2007;28:93–99
  16. Kruse AJ, Skaland I, Janssen EA, Buhr-Wildhagen S, et al. Quantitative molecular parameters to identify low-risk and high-risk early CIN lesions: role of markers of proliferative activity and differentiation and Rb availability. Int J Gynecol Pathol. 2004;23:100–109
  17. Payne S, Kernohan NM, Walker F. Proliferation in the normal cervix and in preinvasive cervical lesions. J Clin Pathol. 1996;49:667–671
  18. Hanselaar AG, Vooijs GP, Mayall BH, et al. DNA changes in progressive cervical intraepithelial neoplasia. Anal Cell Pathol. 1992;4:315–324
  19. Mitra AB, Murty VV, Singh V, et al. Genetic alterations at 5p15: a potential marker for progression of precancerous lesions of the uterine cervix. J Natl Cancer Inst. 1995;87:742–745
  20. Lawrence WD, Abdul-Karim FW, Crum C, et al. Recommendations for the reporting of surgical specimens containing uterine cervical neoplasms. Mod Pathol. 2000;13:1029–1033
  21. Cordes VC, Reidenbach S, Franke WW. Cytoplasmic annulate lamellae in cultured cells: composition, distribution, and mitotic behavior. Cell Tissue Res. 1996;284:177–191
  22. Knoess M, Kurz AK, Goreva O, et al. Nucleoporin 88 expression in hepatitis B and C virus–related liver diseases. World J Gastroenterol. 2006;12:5870–5874

PII: S1092-9134(09)00059-8

doi: 10.1016/j.anndiagpath.2009.05.005

Annals of Diagnostic Pathology
Volume 13, Issue 5 , Pages 303-307 , October 2009

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