Annals of Diagnostic Pathology
Volume 13, Issue 5 , Pages 308-312, October 2009

Comparative analysis of the expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinoma

  • Fernando Augusto Cervantes Garcia de Sousa, PhD

      Affiliations

    • Oral Biopathology, São José dos Campos Dental School, São Paulo State University, UNESP, 12242-500 São José dos Campos, SP, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 12 3923 9080.
    • ,
  • Thaís Cachuté Paradella, PhD

      Affiliations

    • Oral Biopathology, São José dos Campos Dental School, São Paulo State University, UNESP, 12242-500 São José dos Campos, SP, Brazil
    • ,
  • Yasmin Rodarte Carvalho

      Affiliations

    • Oral Pathology, São José dos Campos Dental School – São Paulo State University, UNESP, 12242-500 São José dos Campos, SP, Brazil
    • ,
  • Luiz Eduardo Blumer Rosa

      Affiliations

    • Oral Pathology, São José dos Campos Dental School – São Paulo State University, UNESP, 12242-500 São José dos Campos, SP, Brazil

published online 13 July 2009.

Abstract 

Several epidemiologic studies have shown the malignant transformation potential of oral lichen planus; however, this potential is subject of much controversy. To evaluate the expression of proteins related to the cell proliferation and apoptosis processes in oral lichen planus, we compared oral lichen planus with oral squamous cell carcinoma. Twenty-four cases of each lesion were submitted according to streptavidin-biotin technique to evaluate the immunohistochemical expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 proteins. χ2 test showed no statistically significant differences between the expression of p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinoma (P > .05). However, the expression of proliferating cell nuclear antigen was significantly lower in oral lichen planus than in oral squamous cell carcinoma (P < .05). No statistically significant differences between the expression of p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinoma were observed, which may be an evidence of the potential of malignant transformation of oral lichen planus.

Keywords: Lichen planus, Squamous cell carcinoma, Immunohistochemistry

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PII: S1092-9134(09)00061-6

doi:10.1016/j.anndiagpath.2009.06.001

Annals of Diagnostic Pathology
Volume 13, Issue 5 , Pages 308-312, October 2009

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