Annals of Diagnostic Pathology
Volume 13, Issue 5 , Pages 313-321 , October 2009

Predictive value of cyclooxygenase 2 and Bcl-2 for cervical lymph node metastasis in mucoepidermoid carcinoma

  • Manal M. Zyada, PhD

      Affiliations

    • Oral Pathology Department, Faculty of Dentistry, Mansoura University, 35516 Egypt
    • Corresponding Author InformationCorresponding author.
    • ,
  • Mohammed E. Grawish, PhD

      Affiliations

    • Oral Biology Department, Faculty of Dentistry, Mansoura University, 35516 Egypt
    • ,
  • Heba M. Elsabaa, PhD

      Affiliations

    • Oral Biology Department, Faculty of Dentistry, Mansoura University, 35516 Egypt

References 

  1. Speight PM, Barrett AW. Salivary gland tumors. Oral Dis. 2002;8:229–240
  2. Kusafuka K, Takizawa Y, Iida Y, Ebihara M, Onitsuka T, Kameya T. Primary nasopharyngeal mucoepidermoid carcinoma in Japanese patients: two case reports with histochemical and immunohistochemical analysis and a review of the literature. Virchows Arch. 2007;450:343–348
  3. Kuo TT, Chan JKC, Wenig BM, Eveson JW. Nasopharyngeal adenocarcinoma and salivary gland-type carcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds). World Health Organization classification tumours: pathology & genetics head and neck tumours. WHO Publications Center, Albany, NY, USA, IARC Press, Lyon, 2005;p 98.
  4. Shaheel Chummun S, McLean NR, Howlett PC, Kelly CG, Welsh AR, Soames JV. Mucoepidermoid carcinoma of the head and neck: a 13-year review. Eur J Plast Surg. 2008;30:277–282
  5. Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 1998;82(7):1217–1224
  6. Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25(7):835–845
  7. Bevilacqua G, Sobel ME, Liotta LA, Steeg PS. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer. 1989;49:5185–5190
  8. Bradley PJ. Distant metastases from salivary glands cancer. ORL J Otorhinolaryngol Relat Spec. 2001;63:233–242
  9. Ellis GL, Auclair P. In: Tumors of the salivary glands. Atlas of tumor pathology, series 3, fascicle 17. Washington: Armed Forces Institute of Pathology; 1996;p. 155–175
  10. Kase S, Osaki M, Honjo S, Adachi H, Tsujitani S, Kaibara N, et al. Expression of cyclo-oxygenase-2 is correlated with high intratumoral microvessel density and low apoptotic index in human esophageal squamous cell carcinomas. Virchows Arch. 2003;442:129–135
  11. Fosslien E. Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Crit Rev Clin Lab Sci. 2000;37:431–502
  12. Farrow DC, Vaughan TL, Hansten Stanford JL, Risch HA, Gammon MD, Chow WH, et al. Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev. 1998;7:97–102
  13. Reddy BS, Maruyama H, Kelloff G. Dose-related inhibition of colon carcinogenesis by dietarypiroxicam, a nonsteroidal anti-inflammatory drug during different stages of rat colon tumor development. Cancer Res. 1987;47:5340–5346
  14. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 1998;93:705–716
  15. Attiga FA, Fernandez PM, Weeraratna AT, Manyak MJ, Patierno SR. Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. Cancer Res. 2000;60:4629–4637
  16. Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 1995;83:493–501
  17. Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci U S A. 1997;94:3336–3340
  18. Wang Y, Szekely L, Okan J, et al. Wild type p53 triggered apoptosis is inhibited by bcl-2 in v-myc induced T-cell lymphoma lines. Oncogene. 1993;8:3427–3431
  19. Johnson MI, Hamdy FC. Apoptosis regulating genes in prostate cancer. [review] Oncol Rep. 1998;5:553–557
  20. Vairo G, Innes KM, Adems JM. BCL-2 has a cycle inhibitory function separable from its enhancement of cell survival. Oncogene. 1996;13:1511
  21. Sakamoto T, Uozaki H, Kondo K, Imauchi Y, Yamasoba T, Sugasawa M, et al. Cyclooxygenase-2 regulates the degree of apoptosis by modulating bcl-2 protein in pleomorphic adenoma and mucoepidermoid carcinoma of the parotid gland. Act Oto-Laryngologica. 2005;125:191–195
  22. In:  Barnes L,  Eveson JW,  Reichart P,  Sindransky D editor. Pathology and genetics of head and neck tumors. World Health Organization classification of tumours. Lyon: IARC Press; 2005;p. 313
  23. Wittenkind C, Greene FL, Hutter RVP, Klimpfinger M, Sobin LH. In: TNM Atlas. 5th ed.. Berlin: Springer; 2004;p. 5–65
  24. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques a comparison between ABC and unlabeled antibody PAP procedures. J Histochem Cytochem. 1981;29:577–580
  25. Segawa E, Sakurai K, Kishimoto H, Takaoka K, Noguchi K, Hashitani S, et al. Expression of cyclooxygenase-2 and DNA topoisomerase II in precancerous and cancerous lesions of the oral mucosa. Oral Oncol. 2008;44:664–671
  26. Ozawa H, Tomita T, Sakamoto K, Tagawa T, Fujii R, Kanzaki S, et al. Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients. Jpn J Clin Oncol. 2008;38(6):414–418
  27. Spiro RH, Huvos AG, Berk R, Strong EW. Mucoepidermoid carcinoma of salivary glands: a clinicopathologic study of 367 cases. Am J Surg. 1978;136:461–468
  28. Suzuki M, Ichimiya I, Matsushita F, Mogi G. Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland. J Laryngol Otol. 1998;112:944–947
  29. Evans HL. Mucoepidermoid carcinoma of salivary glands. a study of 69 cases with special attention to histologic grading. Am J Clin Pathol. 1984;81(6):696–701
  30. Kaklamanis L, Savage A, Mortensen N, Tsiotos P, Anagnostopoulou ID, Biddolph S, et al. Early expression of BCL-2 protein in the adenoma-carcinoma sequence of colorectal neoplasia. J Pathol. 1996;179:10
  31. Friess H, Lu Z, Graber HU, Zimmermann A, Alder G, Korc M, et al. Bax, but not bcl-2, influences the prognosis of human pancreatic cancer. Gut. 1998;43:414–421
  32. Hu YX, Watanabe H, Ohisubo K, et al. BCL-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma. Br J Cancer. 1999;80:1075–1079
  33. Eid H, Gulyas M, Geczi L, Bodrogi I, Institoris E, Bak M. Expression of BCL-2 in testicular carcinoma. Cancer. 1998;83:331–336
  34. Rochaix P, Krajewski S, Reed JC, Bonnet F, Voigt JJ, Brousset F. In vivo patterns of BCL-2 family protein expression in breast carcinoma in relation to apoptosis. J Pathol. 1999;187:410–415
  35. Itoh S, Matsui K, Furuta I, Takano Y. Immunohistochemical study on overexpression of cyclooxgenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor. Oral Oncol. 2003;39:829–835
  36. Yanez M, Roa T, Garcia M, Ibacache G, Villaseca M. BCL-2 gene protein expression in salivary gland tumors. Rev Med Chil. 1999;127(2):139–142
  37. Yoshikawa R, Sano H, Masuda C, Tsubouchi Y, Chargui J, Yoshimura N, et al. Expression of cyclooxygenase-2 in prostate carcinoma. Cancer. 2000;89:589–596
  38. Peng J, Su C, Chang H, Chai C, Hung W. Overexpression of cyclooxygenase 2 in squamous cell carcinoma of the hypopharynx. Hum Pathol. 2002;33:101–104
  39. Zimmermann KC, Sarbia M, Weber A, Borchard F, Gabbert HE, Schror K. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 1999;59:198–204
  40. Huang M, Stolina M, Sharma S, Mao JT, Zhu L, Miller PW, et al. Non-small cell lung cancer cyclooxygenase-2 dependent regulation of cytokine balance in lymphocytes and macrophage: up-regulation of interleukin 10 and down-regulation of interleukin 12 production. Cancer Res. 1998;58:1208–1216
  41. Yin HF, Okada N, Takagi M. Apoptosis and apoptotic-related factors in mucoepidermoid carcinoma of the minor salivary glands. Pathol Int. 2000;50(8):603
  42. Siziopikou KP, Prioleau JE, Harris JR, Schnit SJ. BCL-2 expression in the spectrum of preinvasive breast lesions. Cancer. 1996;77:499–506
  43. Yang E, et al. Prognostic value of BCL-2 in invasive breast cancer receiving chemotherapy and endocrine therapy. Oncol Rep. 2003;10(1):121–125
  44. Shibata M, Kodani I, Osaki M, Araki K, Adachi H, Ryoke K, et al. Cyclo-oxygenase-1 and 2-expression in human oral mucosa, dysplasia and squamous cell carcinomas and their pathological significance. Oral Oncol. 2005;41:304–312
  45. Tsubochi H, Sato N, Hiyama M, Kaimori M, Endo S, Sohara Y, et al. Combined analysis of cyclooxygenase-2 expression with p35 and ki-67 in non small cell lung cancer. Ann Thorac Surg. 2006;82:1198–1204
  46. Smith ML, Hawcroft G, Hull MA. The effect of nonsteroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. Eur J Cancer. 2000;36:664–674
  47. Watson AJ. Chemopreventive effects of NSAIDs against colorectal cancer: regulation of apoptosis and mitosis by COX-1 and -2. Histol Histopathol. 1998;13:591–597

PII: S1092-9134(09)00062-8

doi: 10.1016/j.anndiagpath.2009.06.003

Annals of Diagnostic Pathology
Volume 13, Issue 5 , Pages 313-321 , October 2009

Article Tools

* Image Usage & Resolution