Annals of Diagnostic Pathology
Volume 14, Issue 3 , Pages 209-214, June 2010

Primary lymphoepithelioma-like carcinoma of the ureter

  • Daniela S. Allende, MD

      Affiliations

    • Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, OH 44195, USA
    • ,
  • Mihir Desai, MD

      Affiliations

    • Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    • ,
  • Donna E. Hansel, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, OH 44195, USA
    • Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    • Taussig Cancer Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    • Genomic Medicine Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    • Corresponding Author InformationCorresponding author. Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, OH 44195, USA. Tel.: +1 216 444 5893; fax: +1 216 445 6967.

published online 04 September 2009.

Abstract 

Lymphoepithelioma-like carcinoma (LELC) is an uncommon tumor of the urinary tract. We present a case of LELC involving the ureter of a 71-year-old male patient with gross hematuria. On biopsy, the patient was diagnosed with invasive poorly differentiated carcinoma, with a final diagnosis of LELC on subsequent nephroureterectomy. On resection, the neoplasm was solitary and consisted of undifferentiated neoplastic cells demonstrating a syncytial growth pattern, vesicular nuclei, prominent nucleoli, and an admixed polyclonal lymphoid infiltrate. Immunohistochemistry showed that the tumor cells were positive for Cam5.2 and CK7; focally positive for cytokeratinAE1/3, EMA, CK20, and p63; and negative for CK903. Epstein-Barr virus in situ hybridization was negative. No disease progression was noted at 5-month follow-up. Only 6 previous cases of LELC involving the ureter have been reported in the literature. We document an additional example of this uncommon entity and present a comprehensive review of LELC involving the ureter.

Keywords: Ureter, Urothelial carcinoma, Lymphoepithelioma-like, Immunohistochemistry, Diagnosis

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PII: S1092-9134(09)00081-1

doi:10.1016/j.anndiagpath.2009.05.007

Annals of Diagnostic Pathology
Volume 14, Issue 3 , Pages 209-214, June 2010

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