Annals of Diagnostic Pathology
Volume 14, Issue 1 , Pages 8-14 , February 2010

Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases

  • Julie C. Fanburg-Smith, MD

      Affiliations

    • Department of Orthopaedic and Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    • Corresponding Author InformationCorresponding author. Soft Tissue & Orthopaedic Pathology, 8403 Colesville Road, Suite 1600, Silver Spring, MD 20910. Tel.: +1 240 485 5100x3752; fax: +1 804 836 1387.
    • ,
  • Aaron Auerbach, MD, MPH

      Affiliations

    • Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    • Department of Immunohistochemistry, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    • ,
  • Jayson S. Marwaha

      Affiliations

    • Department of Orthopaedic and Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    • ,
  • Zengfeng Wang, PhD

      Affiliations

    • Department of Immunohistochemistry, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    • ,
  • Mariarita Santi, MD

      Affiliations

    • Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA
    • ,
  • Alexander R. Judkins, MD

      Affiliations

    • Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA
    • ,
  • Elisabeth J. Rushing, MD

      Affiliations

    • Department of Neuropathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA

References 

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  8. Vencio EF, Reeve CM, Unni KK, Nascimento AG. Mesenchymal chondrosarcoma of the jaw bones: clinicopathologic study of 19 cases. Cancer. 1998;82(12):2350–2355
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  10. Salvati M, Caroli E, Frati A, Piccirilli M, Agrillo A, Brogna C, et al. Central nervous system mesenchymal chondrosarcoma. J Exp Clin Cancer Res. 2005;24(2):317–324
  11. Fletcher CD, Krausz T. Cartilaginous tumours of soft tissue. Appl Pathol. 1988;6(3):208–220
  12. Scheithauer BW, Rubinstein LJ. Meningeal mesenchymal chondrosarcoma: report of 8 cases with review of the literature. Cancer. 1978;42(6):2744–2752
  13. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29(4):577–580
  14. Kulyk WM, Franklin JL, Hoffman LM. Sox9 expression during chondrogenesis in micromass cultures of embryonic limb mesenchyme. Exp Cell Res. 2000;255(2):327–332
  15. Hoang MP, Suarez PA, Donner LR, Ro Y, Ordonez NG, Ayala AG, et al. Mesenchymal chondrosarcoma: a small cell neoplasm with polyphenotypic differentiation. Int J Surg Pathol. 2000;8(4):291–301
  16. Wehrli BM, Huang W, de CB, Ayala AG, Czerniak B. Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. Hum Pathol. 2003;34(3):263–269
  17. Soderstrom M, Bohling T, Ekfors T, Nelimarkka L, Aro HT, Vuorio E. Molecular profiling of human chondrosarcomas for matrix production and cancer markers. Int J Cancer. 2002;100(2):144–151
  18. Sainati L, Scapinello A, Montaldi A, Bolcato S, Ninfo V, Carli M, et al. A mesenchymal chondrosarcoma of a child with the reciprocal translocation (11;22)(q24;q12). Cancer Genet Cytogenet. 1993;71(2):144–147
  19. Judkins AR. Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology. Adv Anat Pathol. 2007;14(5):335–339
  20. Versteege I, Sevenet N, Lange J, Rousseau-Merck MF, Ambros P, Handgretinger R, et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature. 1998;394(6689):203–206
  21. Biegel JA. Molecular genetics of atypical teratoid/rhabdoid tumor. Neurosurg Focus. 2006;20(1):E11
  22. Roberts CW, Orkin SH. The SWI/SNF complex—chromatin and cancer. Nat Rev Cancer. 2004;4(2):133–142
  23. Judkins AR, Mauger J, Ht A, Rorke LB, Biegel JA. Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms. Am J Surg Pathol. 2004;28(5):644–650
  24. Raoux D, Peoc'h M, Pedeutour F, Vaunois B, Decouvelaere AV, Folpe AL. Primary epithelioid sarcoma of bone: report of a unique case, with immunohistochemical and fluorescent in situ hybridization confirmation of INI1 deletion. Am J Surg Pathol. 2009;33(6):954–958
  25. Hornick JL, Dal CP, Fletcher CD. Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Am J Surg Pathol. 2009;33(4):542–550

PII: S1092-9134(09)00109-9

doi: 10.1016/j.anndiagpath.2009.09.003

Annals of Diagnostic Pathology
Volume 14, Issue 1 , Pages 8-14 , February 2010

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