Annals of Diagnostic Pathology
Volume 14, Issue 1 , Pages 15-22 , February 2010

Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1α: a histologic and immunohistochemical study of 45 cases

References 

  1. Geissler B, Fleischmann R, Wagner T. Angiosarcoma of the spleen. Case report and review of the literature. Langenbecks Arch Chir. 1997;382:226–230
  2. Mark RJ, Poen JC, Tran LM. Angiosarcoma. A report of 67 patients and a review of the literature. Cancer. 1996;77:2400–2406
  3. Meis-Kindblom JM, Kindblom LG. Angiosarcoma of soft issue: a study of 80 cases. Am J Surg Pathol. 1998;22:683–697
  4. Rathmell WK, Acs G, Simon MC, et al. HIF transcription factor expression and induction of hypoxic response genes in a retroperitoneal angiosarcoma. Anticancer Res. 2004;24(1):167–169
  5. Amo Y, Masuzawa M, Hamada Y, et al. Expression of vascular endothelial growth factor in a human hemangiosarcoma cell line (ISO-HAS). Arch Dermatol Res. 2001;293(6):296–301
  6. Zietz C, Rössle M, Haas C, et al. MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas. Am J Pathol. 1998;153(5):1425–1433
  7. Tsuzuki Y, Fukumura D, Oosthuyse B, et al. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha → hypoxia response element → VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res. 2000;60(22):6248–6252
  8. Deyrup AT, McKenney JK, Tighiouart M, Folpe AL, Weiss SW. Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases. Am J Surg Pathol. 2008;32(1):72–77
  9. Köhler HF, Neves RI, Brechtbühl ER, Mattos Granja NV, Ikeda MK, Kowalski LP. Cutaneous angiosarcoma of the head and neck: report of 23 cases from a single institution. Otolaryngol Head Neck Surg. 2008;139(4):519–524
  10. Bessis D, Sotto A, Roubert P, Chabrier PE, Mourad G, Guilhou JJ. Endothelin-secreting angiosarcoma occurring at the site of an arteriovenous fistula for haemodialysis in a renal transplant recipient. Br J Dermatol. 1998;138(2):361–363
  11. Wehrli BM, Janzen DL, Shokeir O, Masri BA, Byrne SK, O'Connell JX. Epithelioid angiosarcoma arising in a surgically constructed arteriovenous fistula: a rare complication of chronic immunosuppression in the setting of renal transplantation. Am J Surg Pathol. 1998;22(9):1154–1159
  12. Fletcher CD, Beham A, Bekir S, Clarke AM, Marley NJ. Epithelioid angiosarcoma of deep soft tissue: a distinctive tumor readily mistaken for an epithelial neoplasm. Am J Surg Pathol. 1991;15(10):915–924
  13. Tallini G, Price FV, Carcangiu ML. Epithelioid angiosarcoma arising in uterine leiomyomas. Am J Clin Pathol. 1994;102(3):388–389
  14. Brown RW, Tornos C, Evans HL. Angiosarcoma arising from malignant schwannoma in a patient with neurofibromatosis. Cancer. 1992;70:1141–1144
  15. Chaudhuri B, Ronan SG, Manaligod JR. Angiosarcoma arising in a plexiform neurofibroma: a case report. Cancer. 1980;46(3):605–610
  16. Ulbright TM, Clark SA, Einhorn LH. Angiosarcoma associated with germ cell tumors. Hum Pathol. 1985;16(3):268–272
  17. Millstein DI, Tang CK, Campbell EW. Angiosarcoma developing in a patient with neurofibromatosis (von Recklinghausen's disease). Cancer. 1981;47(5):950–954
  18. Dunkel IJ, Gerald WL, Rosenfield NS, Strong EW, Abramson DH, Ghavimi F. Outcome of patients with a history of bilateral retinoblastoma treated for a second malignancy: the Memorial Sloan-Kettering experience. Med Pediatr Oncol. 1998;30(1):59–62
  19. Leake J, Sheehan MP, Rampling D, Ramani P, Atherton DJ. Angiosarcoma complicating xeroderma pigmentosum. Histopathology. 1992;21(2):179–181[No abstract available]
  20. Popper H, Thomas LB, Telles NC, Falk H, Selikoff IJ. Development of hepatic angiosarcoma in man induced by vinyl chloride, thorotrast, and arsenic. Comparison with cases of unknown etiology. Am J Pathol. 1978;92(2):349–376
  21. Mark L, Delmore F, Creech JL, Ogden LL, Fadell EH, et al. Clinical and morphologic features of hepatic angiosarcoma in vinyl chloride workers. Cancer. 1976;37(1):149–163
  22. Przygodzki RM, Finkelstein SD, Keohavong P, Zhu D, et al. Sporadic and thorotrast-induced angiosarcomas of the liver manifest frequent and multiple point mutations in K-ras-2. Lab Invest. 1997;76(1):153–159
  23. Folpe AL, Veikkola T, Valtola R, Weiss SW. Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. Mod Pathol. 2000;13(2):180–185
  24. Fanburg-Smith JC, Michal M, Partanen TA, Alitalo K, Miettinen M. Papillary intralymphatic angioendothelioma (PILA): a report of twelve cases of a distinctive vascular tumor with phenotypic features of lymphatic vessels. Am J Surg Pathol. 1999;23(9):1004–1010
  25. Wykoff CC, Beasley NJ, Watson PH, et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res. 2000;60(24):7075–7083
  26. Pugh CW, Ratcliffe PJ. The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. Semin Cancer Biol. 2003;13(1):83–89
  27. Iliopoulos O, Levy AP, Jiang C, Kaelin WG, Goldberg MA. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci USA. 1996;93(20):10595–10599
  28. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science. 2001;292(5516):464–468
  29. Tanimoto K, Makino Y, Pereira T, Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J. 2000;19(16):4298–4309
  30. Wiesener MS, Münchenhagen PM, Berger I, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res. 2001;61(13):5215–5222
  31. Ma W, Tessarollo L, Hong SB, et al. Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res. 2003;63(17):5320–5328

PII: S1092-9134(09)00111-7

doi: 10.1016/j.anndiagpath.2009.09.005

Annals of Diagnostic Pathology
Volume 14, Issue 1 , Pages 15-22 , February 2010

Article Tools

* Image Usage & Resolution