Annals of Diagnostic Pathology
Volume 14, Issue 4 , Pages 279-283 , August 2010

Dermatofibrosarcoma protuberans in the breast of a 2-year-old girl

  • Atif A. Ahmed, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, MO 64801, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 816 234 3234; fax: +1 816 802 1492.
    • ,
  • Daniel Ostlie, MD

      Affiliations

    • Department of Surgery, Children's Mercy Hospital, Kansas City, MO 64801, USA
    • ,
  • Jason D. Fraser, MD

      Affiliations

    • Department of Surgery, Children's Mercy Hospital, Kansas City, MO 64801, USA
    • ,
  • Brandon Newell, MD

      Affiliations

    • Department of Dermatology, Children's Mercy Hospital, Kansas City, MO 64801, USA
    • ,
  • Linda Cooley, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, MO 64801, USA

References 

  1. Korkolis DP, Liapakis IE, Vassilopoulos PP. Dermatofibrosarcoma protuberans: clinicopathological aspects of an unusual cutaneous tumor. Anticancer Res. 2007;27:1631–1634
  2. Mendenhall WM, Zlotecki RA, Scarborough MT. Dermatofibrosarcoma protuberans. Cancer. 2004;101:2503–2508
  3. Gerlini G, Mariotti G, Urso C, et al. Dermatofibrosarcoma protuberans in childhood: two case reports and review of the literature. Pediatr Hematol Oncol. 2008;25:559–566
  4. Maire G, Fraitag S, Galmiche L, et al. A clinical, histologic, and molecular study of 9 cases of congenital dermatofibrosarcoma protuberans. Arch Dermatol. 2007;143:203–210
  5. Mentzel T, Beham A, Katenkamp D, et al. Fibrosarcomatous (“high-grade”) dermatofibrosarcoma protuberans: clinicopathologic and immunohistochemical study of a series of 41 cases with emphasis on prognostic significance. Am J Surg Pathol. 1998;22:576–587
  6. Abbott JJ, Oliveira AM, Nascimento AG. The prognostic significance of fibrosarcomatous transformation in dermatofibrosarcoma protuberans. Am J Surg Pathol. 2006;30:436–443
  7. Reimann JDR, Fletcher CDM. Myxoid dermatofibrosarcoma protuberans: a rare variant analyzed in a series of 23 cases. Am J Surg Pathol. 2007;31:1371–1377
  8. Sigel JE, Bergfeld WF, Goldblum JR. A morphologic study of dermatofibrosarcoma protuberans: expansion of a histologic profile. J Cutan Pathol. 2000;27:159–163
  9. Jha P, Moosavi C, Fanburg-Smith JC. Giant cell fibroblastoma: an update and addition of 86 new cases from the Armed Forces Institute of Pathology, in honor of Dr. Franz M. Enzinger. Ann Diagn Pathol. 2007;11:81–88
  10. Patel KU, Szabo SS, Hernandez VS, et al. Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridization assays. Hum Pathol. 2008;39:184–193
  11. Terrier-Lacombe MJ, Guillou L, Maire G, et al. Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data–a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol. 2003;27:27–39
  12. Maire G, Martin L, Michalak-Provost S, et al. Fusion of COL1A1 exon 29 with PDGFB exon 2 in a der(22)t(17;22) in a pediatric giant cell fibroblastoma with a pigmented Bednar tumor component. Evidence for age-related chromosomal pattern in dermatofibrosarcoma protuberans and related tumors. Genes Chrom Cancer. 2003;37:1–19
  13. Lin JY, Sheen-Chen SM, Hsu W, et al. Dermatofibrosarcoma protuberans of the breast. Tumori. 2008;94:861–863
  14. Bulliard C, Murali R, Chang LY, et al. Subcutaneous dermatofibrosarcoma protuberans in skin of the breast: may mimic a primary breast lesion. Pathol. 2007;39:446–448
  15. Ramakrishnan V, Shoher A, Ehrlich M, et al. Atypical dermatofibrosarcoma protuberans in the breast. Breast J. 2005;11:217–218
  16. Gu W, Ogose A, Kawashima H, et al. Congenital dermatofibrosarcoma protuberans with fibrosarcomatous and myxoid change. J Clin Pathol. 2005;58:984–986
  17. Weinstein JM, Drolet BA, Esterly NB, et al. Congenital dermatofibrosarcoma protuberans: variability in presentation. Arch Dermatol. 2003;139:207–211
  18. Fisher C, Montgomery C, Healy V. Calponin and h-caldesmon expression in synovial sarcoma; the use of calponin in the diagnosis. Histopathol. 2003;42:588–593
  19. Kaur S, Vauhkonen H, Bohling T, et al. Gene copy number changes in dermatofibrosarcoma protuberans—a fine resolution study using array comparative genomic hybridization. Cytogenet Genome Res. 2006;115:283–288
  20. Mcarthur G. Dermatofibrosarcoma protuberans. Recent clinical progress. Ann Surg Oncol. 2007;14:2876–2886
  21. Lemm D, Mugge LO, Mentzel T, et al. Current treatment options in dermatofibrosarcoma protuberans. J Cancer Res Clin Oncol. 2009;135:653–665

PII: S1092-9134(09)00114-2

doi: 10.1016/j.anndiagpath.2009.09.007

Annals of Diagnostic Pathology
Volume 14, Issue 4 , Pages 279-283 , August 2010

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