Annals of Diagnostic Pathology
Volume 14, Issue 4 , Pages 292-295, August 2010

Auer rod–like inclusions in a low-grade B-cell leukemia

  • Alexandra C. Hristov, MD

      Affiliations

    • Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    • ,
  • Andrew Saladino, MD

      Affiliations

    • Veterans Affairs Medical Center, Baltimore, MD 21211, USA
    • ,
  • Victor E. Nava, MD, PhD

      Affiliations

    • Kaiser Permanente, Regional Laboratory Rockville, Rockville, MD 20852, USA
    • ,
  • Christopher D. Gocke, MD

      Affiliations

    • Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 410 955 8363; fax: +1 410 614 7440.

published online 05 April 2010.

Abstract 

Auer rods define neoplastic blasts of myeloid origin. However, azurophilic, needle-shaped, Auer rod–like inclusions have rarely been reported in the neoplastic cells of patients with B-cell malignancies, including chronic lymphocytic leukemia/small lymphocytic lymphoma. Here, we report a case of low-grade B-cell leukemia most consistent with chronic lymphocytic leukemia/small lymphocytic lymphoma that displayed numerous intracytoplasmic, needle-shaped, azurophilic rods resembling Auer rods. Furthermore, we review the literature on Auer rod–like structures in B-cell neoplasms.

Keywords: Auer rod–like inclusions, B-cell leukemia

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PII: S1092-9134(09)00116-6

doi:10.1016/j.anndiagpath.2009.07.005

Annals of Diagnostic Pathology
Volume 14, Issue 4 , Pages 292-295, August 2010

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