Annals of Diagnostic Pathology
Volume 14, Issue 6 , Pages 447-452 , December 2010

Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma

  • Hélder Antônio Rebelo Pontes, DDS, MSc, PhD

      Affiliations

    • João de Barros Barreto University Hospital, Federal University of Pará, 66073-000 Pará, Brazil
    • ,
  • Flávia Sirotheau Corrêa Pontes, DDS, MSc, PhD

      Affiliations

    • João de Barros Barreto University Hospital, Federal University of Pará, 66073-000 Pará, Brazil
    • ,
  • Brunno Santos de Freitas Silva, DDS, MSc

      Affiliations

    • Department of Stomatology (Oral Pathology), Dental School, University of São Paulo, 05508-000 São Paulo, Brazil
    • ,
  • Sérgio Elias Vieira Cury, DDS, MSc, PhD

      Affiliations

    • Department of Stomatology (Oral Pathology), Dental School, UNIFOA, 27240-560 Rio de Janeiro, Brazil
    • ,
  • Felipe Paiva Fonseca, DDS

      Affiliations

    • João de Barros Barreto University Hospital, Federal University of Pará, 66073-000 Pará, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 91 32331581.
    • ,
  • Rodrigo Alves Salim, DDS

      Affiliations

    • João de Barros Barreto University Hospital, Federal University of Pará, 66073-000 Pará, Brazil
    • ,
  • Décio dos Santos Pinto Júnior, DDS, MSc, PhD

      Affiliations

    • Department of Stomatology (Oral Pathology), Dental School, University of São Paulo, 05508-000 São Paulo, Brazil

References 

  1. Zabolinejada N, Hiradfar M, Anvari K, Razavi AS. Ameloblastic fibrosarcoma of the maxillary sinus in an infant: a case report with long-term follow-up. J Ped Surg. 2008;43:E5–E8
  2. Kobayashi K, Murakami R, Fujii T, Hirano A. Malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma: case report and review of the literature. J CranioMaxillofac Surg. 2005;33:352–355
  3. Muller S, Parker DC, Kapadia SB, Budnick SD, Barnes EL. Ameloblastic fibrosarcoma of the jaws. A clinicopathologic and DNA analysis of five cases and review of the literature with discussion of its relationship to ameloblastic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79:469–477
  4. Paula AMB, Costa Neto JQ, Gusmão ES, Santos FBG, Gomez RS. Immunolocalization of the p53 protein in a case of ameloblastic fibrosarcoma. J Oral Maxillofac Surg. 2003;61:256–258
  5. Bologna-Molina R, Mosqueda A, Lopez-Corella E, et al. Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplasic ameloblastomas and ameloblastic carcinoma. Pathol Int. 2009;59:229–233
  6. Hayashi Y, Tohnai I, Uedaa U, Nagasaka T. Sarcomatous overgrowth in recurrent ameloblastic fibrosarcoma. Oral Oncol. 1999;35:346–348
  7. Kunkel M, Ghalibafianb M, Radner H, Reichert TE, Fischer B, Wagner W. Ameloblastic fibrosarcoma or odontogenic carcinosarcoma: a matter of classification?. Oral Oncol. 2004;40:444–449
  8. Williams MD, Hanna EY, El-Naggar AK. Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:72–75
  9. Luo HY, Yu SF, Li TJ. Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas. Int J Oral Maxillofac Surg. 2006;35:750–755
  10. Bast BT, Pogrel MA, Regezi JA. The expression of apoptotic proteins and matrix metalloproteinases in odontogenic myxomas. J Oral Maxillofac Surg. 2003;61:1463–1466
  11. Iezzi G, Piattelli A, Rubini C, Artese L, Fioroni M, Carinci F. MIB-1, Bcl-2 and p53 in odontogenic myxomas of the jaws. Acta Otorhinolaryngol Ital. 2007;27:237–242
  12. Meer S, Galpin JS, Altini M, Coleman H, Ali H. Proliferating cell nuclear antigen and Ki67 immunoreactivity in ameloblastomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:213–221
  13. Sano K, Yoshida S, Ninomiya H, Ikeda H, Ueno K, Sekine J, et al. Assessment of growth potential by MIB-1 immunohistochemistry in ameloblastic fibroma and related lesions of the jaws compared with ameloblastic fibrosarcoma. J Oral Pathol Med. 1998;27:59–63
  14. Oliveira MG, Lauxen IS, Chaves ACM, Rados PV, Filho MS. Immunohistochemical analysis of the patterns of p53 and PCNA expression in odontogenic cystic lesions. Med Oral Patol Oral Cir Bucal. 2008;13(5):E275–E280
  15. Sandra F, Mitsuyasu T, Nakamura N, Shiratsuchi Y, Ohishi M. Immunohistochemical evaluation of PCNA and Ki-67 in ameloblastomas. Oral Oncol. 2001;37:193–198
  16. Xavier FCA, Rodini CO, Ramalho LMP, Sarmento VA, Nunes FD, Sousa SCOM. Clear cell odontogenic carcinoma: case report with immunohistochemical findings adding support to the challenging diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:403–410
  17. Huguet P, Castellví J, Avila M, et al. Ameloblastic fibrosarcoma: report of a case. Immunohistochemical study and review of the literature. Med Oral. 2001;6(3):173–179
  18. Gong Y, Wang L, Wang H, Li T, Chen X. The expression of NF-κB, Ki-67 and MMP-9 in CCOT, DGCT and GCOC. Oral Oncol. 2009;45:515–520

PII: S1092-9134(09)00145-2

doi: 10.1016/j.anndiagpath.2009.10.007

Annals of Diagnostic Pathology
Volume 14, Issue 6 , Pages 447-452 , December 2010

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