Annals of Diagnostic Pathology
Volume 15, Issue 1 , Pages 58-63 , February 2011

Cytokeratin-, calponin-, and p63-positive chondroblastoma with extensive soft tissue involvement and vascular invasion: a potential diagnostic dilemma

  • Yong Howe Ho, MBBS

      Affiliations

    • Department of Pathology, Tan Tock Seng Hospital, Singapore 308433, Singapore
    • ,
  • Mathew Hern Wang Cheng, FRCS (Edin)

      Affiliations

    • Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore
    • ,
  • Wai Ming Yap, FRCPath

      Affiliations

    • Department of Pathology, Tan Tock Seng Hospital, Singapore 308433, Singapore
    • ,
  • Khoon Leong Chuah, FRCPA

      Affiliations

    • Department of Pathology, Tan Tock Seng Hospital, Singapore 308433, Singapore
    • Corresponding Author InformationCorresponding author. Fax: +65 62560534.

References 

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  2. Ewing J. In: 3rd ed.. Neoplastic diseases: a treatise on tumors. Philadelphia: WB Saunders; 1928;p. 293
  3. Codman EA. Epiphyseal chondromatous giant cell tumors of the upper end of the humerus. Surg Gynecol Obstet. 1931;52:543–548
  4. Jaffe HL, Lichtenstein L. Benign chondroblastoma of bone. A reinterpretation of the so-called calcifying or chondromatous giant cell tumor. Am J Pathol. 1942;18:969–991
  5. Harish K, Janaki MG, Kishore Alva N. “Primary” aggressive chondroblastoma of the humerus: a case report. BMC Musculoskletal Disord. 2004;5:9
  6. Kyriakos M, Land VJ, Penning HL, et al. Metastatic chondroblastoma. Report of a fatal case with a review of the literature on atypical, aggressive, and malignant chondroblastoma. Cancer. 1985;55:1770–1789
  7. de Silva MVC, Reid R. Chondroblastoma: varied histologic appearance, potential diagnostic pitfalls, and clinicopathologic features associated with local recurrence. Ann Diagn Pathol. 2003;7:205–213
  8. Edel G, Ueda Y, Nakanishi J, et al. Chondroblastoma of bone. A clinical, radiological, light and immunohistochemical study. Virchows Archiv A Pathol Anat. 1992;421:355–366
  9. de Pinieux G, Beabout JW, Unni KK, et al. Primary mixed tumor of bone. Skeletal Radiol. 2001;30(9):534–536
  10. Alberghini M, Pasquinelli G, Zanella L, et al. Primary malignant myoepithelioma of the distal femur. APMIS. 2007;115(4):376–380
  11. Takeda Y. An immunohistochemical study of bizarre neoplastic cells in pleomorphic adenoma: its cytological nature and proliferative activity. Pathol Int. 1999;49(11):993–999
  12. Hornick JL, Fletcher CD. Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters. Am J Surg Pathol. 2003;27(9):1183–1196
  13. Semmelink HJ, Pruszczynski M, Wiersma-van Tilburg A, et al. Cytokeratin expression in chondroblastomas. Histopathology. 1990;16(3):257–263
  14. Lee CH, Espinosa I, Jensen KC, et al. Gene expression profiling identifies p63 as diagnostic marker for giant cell tumor of the bone. Mod Pathol. 2008;21(5):531–539
  15. Schajowicz F, de Prospero JD, Cosentine E. Case report 641. Skeletal Radiol. 1990;19:603–606
  16. Elek EM, Grimmer RJ, Mangham D, et al. Malignant chondroblastoma of the os calcis. Sarcoma. 1998;2:45–48
  17. Posl M, Werner M, Amling M, et al. Malignant transformation of chondroblastoma. Histopathology. 1996;29:477–480
  18. Sirsat MV, Vatsala M. Benign chondroblastoma of bone. Report of a case of malignant transformation. J Bone Joint Surg. 1970;52B:741–745

PII: S1092-9134(09)00169-5

doi: 10.1016/j.anndiagpath.2009.12.008

Annals of Diagnostic Pathology
Volume 15, Issue 1 , Pages 58-63 , February 2011

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