Annals of Diagnostic Pathology
Volume 14, Issue 3 , Pages 215-230 , June 2010

Benign cardiac tumors and tumorlike conditions

  • Deepali Jain, MD

      Affiliations

    • Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
  • ,
  • Joseph J. Maleszewski, MD

      Affiliations

    • Division of Anatomical Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
  • ,
  • Marc K. Halushka, MD, PhD

      Affiliations

    • Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
    • Corresponding Author InformationCorresponding author. Tel.: +1 410 614 8138; fax: +1 410 502 5862.

References 

  1. Boikos SA, Stratakis CA. Carney complex: the first 20 years. Curr Opin Oncol. 2007;19:24–29
  2. Wilkes D, Charitakis K, Basson CT. Inherited disposition to cardiac myxoma development. Nat Rev Cancer. 2006;6:157–165
  3. Curatolo P, Bombardieri R, Jozwiak S. Tuberous sclerosis. Lancet. 2008;372:57–668
  4. Lo Muzio L. Nevoid basal cell carcinoma syndrome (Gorlin syndrome). Orphanet J Rare Dis. 2008;3:32
  5. Burke AP, Rosado-de-Christenson M, Templeton PA, et al. Cardiac fibroma: clinicopathologic correlates and surgical treatment. J Thorac Cardiovasc Surg. 1994;108:862–870
  6. Callender GG, Rich TA, Perrier ND. Multiple endocrine neoplasia syndromes. Surg Clin North Am. 2008;88:863–895
  7. Ku CF, Lo CY, Chan WF, et al. Resection of pheochromocytoma extending into the right atrium in a patient with multiple endocrine neoplasia type 2A. Hong Kong Med J. 2005;11:59–62
  8. Shehata BM, Patterson K, Thomas JE, et al. Histiocytoid cardiomyopathy: three new cases and a review of the literature. Pediatr Dev Pathol. 1998;1:56–69
  9. Finsterer J. Histiocytoid cardiomyopathy: a mitochondrial disorder. Clin Cardiol. 2008;31:225–227
  10. Reynen K. Frequency of primary tumors of the heart. Am J Cardiol. 1996;77:107
  11. Burke AP, Virmani R. Cardiac myxoma. In:  Rosai J,  Sobin LH editor. Tumors of the heart and great vessels. 3rd ed.. Washington (DC): Armed Forces Institute of Pathology; 1996;p. 21–47
  12. Chopra P, Ray R, Airan B, et al. Appraisal of histogenesis of cardiac myxoma: our experience of 78 cases and review of literature. Indian Heart J. 1999;51:69–74
  13. Kodama H, Hirotani T, Suzuki Y, et al. Cardiomyogenic differentiation in cardiac myxoma expressing lineage-specific transcription factors. Am J Pathol. 2002;161:381–389
  14. Carney JA. Differences between nonfamilial and familial cardiac myxoma. Am J Surg Pathol. 1985;9:53–55
  15. Carney JA, Gordon H, Carpenter PC, et al. The complex of myxomas, spotty pigmentation, and endocrine overactivity. Medicine. 1985;64:270–283
  16. Matyakhina L, Pack S, Kirschner LS, et al. Chromosome 2 (2p16) abnormalities in Carney complex tumors. J Med Genet. 2003;40:268–277
  17. Karga H, Papaioannou P, Karayianni M, et al. Ras oncogenes and p53 tumor suppressor gene analysis in cardiac myxomas. Pathol Res Pract. 2000;196:601–605
  18. Li Y, Pan Z, Ji Y, et al. Herpes simplex virus type 1 infection associated with atrial myxoma. Am J Pathol. 2003;163:2407–2412
  19. Reyen K. Cardiac myxomas. N Engl J Med. 1995;333:1610–1617
  20. Bjessmo S, Ivert T. Cardiac myxoma: 40 years' experience in 63 patients. Ann Thorac Surg. 1997;63:697–700
  21. Yokomuro H, Yoshihara K, Watanabe Y, et al. The variations in the immunologic features and interleukin-6 levels for the surgical treatment of cardiac myxomas. Surg Today. 2007;37:750–753
  22. Blanchard DG, DeMaria AN. Cardiac and extracardiac masses: echocardiographic evaluation. In:  Skorton DJ editors. Marcus cardiac imaging: a companion to Braunwald's heart disease. 2nd ed. Philadelphia (Pa): Saunders; 1996;p. 452–480
  23. Engberding R, Daniel WG, Erbel R, et al. Diagnosis of heart tumours by transoesophageal echocardiography: a multicentre study in 154 patients. European Cooperative Study Group. Eur Heart J. 1993;14:1223–1228
  24. Burke AP, Virmani R. Cardiac myxoma: a clinicopathologic study. Am J Clin Pathol. 1993;100:671–680
  25. Martìn-Suàrez S, Botta L, Dell'Amore A, et al. Mitral valve myxoma involving both leaflets. Cardiovasc Pathol. 2007;16:189–190
  26. Sakamoto H, Sakamaki T, Kanda T, et al. Vascular endothelial growth factor is an autocrine growth factor for cardiac myxoma cells. Circ J. 2004;68:488–493
  27. Vaideeswar P, Butany JW. Benign cardiac tumors of the pluripotent mesenchyme. Semin Diagn Pathol. 2008;25:20–28
  28. Miller DV, Tazelaar HD, Handy JR, et al. Thymoma arising within cardiac myxoma. Am J Surg Pathol. 2005;29:1208–1213
  29. Hemachandran M, Kakkar N, Khandelwal N. Giant-cell-rich myxoma of right atrium. An ultrastructural analysis. Cardiovasc Pathol. 2003;12:287–289
  30. Kusumi T, Minakawa M, Fukui K, et al. Cardiac tumor comprising two components including typical myxoma and atypical hypercellularity suggesting a malignant change. Cardiovasc Pathol. 2009;18:369–374
  31. Acebo E, Val-Bernal JF, Gomez-Roman JJ. Thrombomodulin, calretinin and c-kit (CD117) expression in cardiac myxoma. Histol Histopathol. 2001;16:1031–1036
  32. Deshpande A, Venugopal P, Kumar AS, et al. Phenotypic characterization of cellular components of cardiac myxoma: a light microscopy and immunohistochemistry study. Hum Pathol. 1996;27:1056–1059
  33. Miller DV, Edwards WD. Cardiovascular tumor-like conditions. Semin Diagn Pathol. 2008 Feb;25(1):54–64
  34. Burke A, Jeudy J, Virmani R. Cardiac tumours: an update: cardiac tumours. Heart. 2008;94:117–123
  35. Fang BR, Chang CP, Cheng CW, et al. Total detachment of cardiac myxoma causing saddle embolization and mimicking aortic dissection. Jpn Heart J. 2004;45:359–363
  36. Ashalatha R, Moosa A, Gupta AK, et al. Cerebral aneurysms in atrial myxoma: a delayed, rare manifestation. Neurol India. 2005;53:216–218
  37. Shahian DM, Labib SB, Chang G. Cardiac papillary fibroelastoma. Ann Thorac Surg. 1995;59:538–541
  38. Le Tourneau T, Pouwels S, Gal B, et al. Assessment of papillary fibroelastomas with live three-dimensional transthoracic echocardiography. Echocardiogr. 2008;25:489–495
  39. Al-Mohammad A, Pambakian H, Young C. Fibroelastoma: case report and review of the literature. Heart. 1998;79:301–304
  40. Khair T, Mazidi P, Laos LF. Cardiac papillary fibroelastoma: case report and review of the literature. Int J Cardiol. 2010;139:102–104
  41. Kurup AN, Tazelaar HD, Edwards WD, et al. Iatrogenic cardiac papillary fibroelastoma: a study of 12 cases (1990 to 2000). Hum Pathol. 2002;33:1165–1169
  42. Okamoto Y, Matsumoto M, Inoue H, et al. Aortic valve papillary fibroelastoma that developed rapidly after open-heart surgery. Interact Cardiovasc Thorac Surg. 2008;7:1134–1136
  43. Gegouskov V, Kadner A, Engelberger L, et al. Papillary fibroelastoma of the heart. Heart Surg Forum. 2008;11:E333–E339
  44. Edwards FH, Hale D, Cohen A, et al. Primary cardiac valve tumors. Ann Thorac Surg. 1991;52:1127–1131
  45. Burke AP, Tazelaar H, Gomez-Roman JJ, et al. Benign tumours of pluripotent mesenchyme. In:  Travis WD,  Brambilla E,  Muller-Hermelink HK,  Harris CC editor. Tumors of the lung, pleura, thymus and heart. Pathology and genetics. World Health Organization International Classification of Tumors. Lyon: IARC Press; 2004;p. 260–265
  46. DiLorenzo WR, Donohue TJ, Ghantous AE. Papillary fibroelastoma arising from the pulmonary valve associated with pulmonary embolization. Conn Med. 2008;72:143–146
  47. Totsugawa T, Kuinose M, Yoshitaka H, et al. Papillary fibroelastoma of the tricuspid valve chordae. Jpn J Thorac Cardiovasc Surg. 2006;54:547–549
  48. Idahosa O, Mallavarapu V, Kostacos E. Papillary fibroelastoma arising from the left atrial free wall. J Am Soc Echocardiogr. 2007;20:1010.e1–1010.e2
  49. Jablonski-Cohen M, Ohsie L, Bhatti T, et al. Unusual left atrial appendage mass: atypical presentation of papillary fibroelastoma. Echocardiogr. 2008;25:514–516
  50. Coskun O, Coskun T, Arusoglu L, et al. Papillary fibroelastoma of the ascending aorta presenting with cardiogenic shock. Minerva Cardioangiol. 2006;54:783–787
  51. Palecek T, Lindner J, Vitkova I, et al. Papillary fibroelastoma arising from the left ventricular apex associated with nonspecific systemic symptoms. Echocardiogr. 2008;25:526–528
  52. Grandmougin D, Fayad G, Moukassa D, et al. Cardiac valve papillary fibroelastomas: clinical, histological and immunohistochemical studies and a physiopathogenic hypothesis. J Heart Valve Dis. 2000;9:832–841
  53. Grinda JM, Couetil JP, Chauvaud S, et al. Cardiac valve papillary fibroelastoma: surgical excision for revealed or potential embolization. J Thorac Cardiovasc Surg. 1999;117:106–110
  54. Hort W, Horskotte D. Fibroelastoma and Lambl's excrescences: localization, morphology and pathogenesis, differential diagnosis and infection. J Heart Valve Dis. 2006;15:591–593
  55. Mutlu H, Demir IE, Leppo J, et al. Nonsurgical management of a left ventricular pedunculated papillary fibroelastoma: a case report. J Am Soc Echocardiogr. 2008;21:877.e4–877.e7
  56. Beghetti M, Gow RM, Haney I, et al. Pediatric primary benign cardiac tumors: a 15-year review. Am Heart J. 1997;134:1107–1114
  57. Aktoz M, Tatlı E, Ege T, et al. Cardiac rhabdomyoma in an adult patient presenting with right ventricular outflow tract obstruction. Int J Cardiol. 2008;28:e105–e107
  58. Yu GH, Kussmaul WG, DiSesa VJ, et al. Adult intracardiac rhabdomyoma resembling the extracardiac variant. Hum Pathol. 1993;24:448–451
  59. Burke AP, Gatto-Weis C, Griego JE, et al. Adult cellular rhabdomyoma of the heart: a report of 3 cases. Hum Pathol. 2002;33:1092–1097
  60. Jozwiak J, Sahin M, Jozwiak S, et al. Cardiac rhabdomyoma in tuberous sclerosis: hyperactive Erk signaling. Int J Cardiol. 2009;132:145–147
  61. Uzun O, Wilson DG, Vujanic GM, et al. Cardiac tumours in children. Orphanet J Rare Dis. 2007;2:11
  62. Chao AS, Chao A, Wang TH, et al. Outcome of antenatally diagnosed cardiac rhabdomyoma: case series and a meta-analysis. Ultrasound Obstet Gynecol. 2008;31:289–295
  63. Wu SS, Collins MH, de Chadarévian JP. Study of the regression process in cardiac rhabdomyomas. Pediatr Dev Pathol. 2002;5:29–36
  64. Burke AP, Tazelaar H, Patel CR, et al. Benign tumours with myocyte differentiation. In:  Travis WD,  Brambilla E,  Muller-Hermelink HK,  Harris CC editor. Tumors of the lung, pleura, thymus and heart. Pathology and genetics. World Health Organization International Classification of Tumors. Lyon: IARC Press; 2004;p. 254–259
  65. Günther T, Schreiber C, Noebauer C, et al. Treatment strategies for pediatric patients with primary cardiac and pericardial tumors: a 30-year review. Pediatr Cardiol. 2008;29:1071–1076
  66. Scanlan D, Radio SJ, Nelson M, et al. Loss of the PTCH1 gene locus in cardiac fibroma. Cardiovasc Pathol. 2008;17:93–97
  67. Ferguson HL, Hawkins EP, Cooley LD. Infant cardiac fibroma with clonal t(1;9)(q32;q22) and review of benign fibrous tissue cytogenetics. Cancer Genet Cytogenet. 1996;87:34–37
  68. Viswanathan S, Gibbs JL, Roberts P. Clonal translocation in a cardiac fibroma presenting with incessant ventricular tachycardia in childhood. Cardiol Young. 2003;13:101–102
  69. Miller DV, Wang H, Wang H, et al. Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis. Pediatr Dev Pathol. 2008;11:291–294
  70. Vidaillet HJ. Cardiac tumors associated with hereditary syndromes. Am J Cardiol. 1988;61:1355
  71. Soler-Soler J, Romero-Gonzalez R. Calcified intramural fibroma of the left ventricle. Eur J Cardiol. 1975;3:71–73
  72. Iqbal MB, Stavri G, Mittal T, et al. A calcified cardiac mass. Int J Cardiol. 2007;115:e126–128
  73. Gotlieb AI. Cardiac fibromas. Semin Diagn Pathol. 2008;25:17–19
  74. Valente M, Cocco P, Thiene G, et al. Cardiac fibroma and heart transplantation. J. Thorac. Cardiovasc Surg. 1993;106:1208–1212
  75. Centofanti P, Di Rosa E, Deorsola L, et al. Primary cardiac tumors: early and late results of surgical treatment in 91 patients. Ann Thorac Surg. 1999;68:1236–1241
  76. Cina SJ, Smialek JE, Burke AP, et al. Primary cardiac tumors causing sudden death: a review of the literature. Am J Forensic Med Pathol. 1996;17:271–281
  77. Burke A, Johns JP, Virmani R. Hemangiomas of the heart: a clinicopathologic study of ten cases. Am J Cardiovasc Pathol. 1990;3:283–290
  78. Muzzi L, Davoli G, Specchia L, et al. Primary hemangioma of the mitral valve: an unusual presentation. J Heart Valve Dis. 2007;16:209–211
  79. De Filippo M, Corradi D, Nicolini F, et al. Hemangioma of the right atrium: imaging and pathology. Cardiovasc Pathol. 2010;19:121–124
  80. Palmer TE, Tresch DD, Bonchek LI. Spontaneous resolution of a large cavernous hemangioma of the heart. Am J Cardiol. 1986;58:184–185
  81. Smith MA. Multiple synchronous atrial lipomas. Cardiovasc Pathol. 2007;16:187–188
  82. Bardakci H, Altintas G, Unal U, et al. Giant cardiac lipoma: report of a case. J Card Surg. 2008;23:254–256
  83. Burke AP, Litovsky S, Virmani R. Lipomatous hypertrophy of the atrial septum presenting as a right atrial mass. Am J Surg Pathol. 1996;20:678–685
  84. Pederzolli C, Terrini A, Ricci A, et al. Pulmonary valve lipoma presenting as syncope. Ann Thorac Surg. 2002;73:1305–1306
  85. Tazelaar HD, Locke TJ, McGregor CG. Pathology of surgically excised primary cardiac tumors. Mayo Clin Proc. 1992;67:957–965
  86. Veinot JP. Cardiac tumors of adipocytes and cystic tumor of the atrioventricular node. Semin Diagn Pathol. 2008;25:29–38
  87. Xanthos T, Giannakopoulos N, Papadimitriou L. Lipomatous hypertrophy of the interatrial septum: a pathological and clinical approach. Int J Cardiol. 2007;121:4–8
  88. Benvenuti LA, Mansur AJ, Lopes DO, et al. Primary lipomatous tumors of the cardiac valves. South Med J. 1996;89:1018–1020
  89. Behnam R, Williams G, Gerlis L, et al. Lipoma of the mitral valve and papillary muscle. Am J Cardiol. 1983;51:1459–1460
  90. Crotty TB, Edwards WD, Oh JK, et al. Lipomatous hamartoma of the tricuspid valve: echocardiographic-pathologic correlations. Clin Cardiol. 1991;14:262–266
  91. Prichard RW. Tumors of the heart: review of the subject and report of 150 cases. AMA Arch Pathol. 1951;51:98–128
  92. Prior JT. Lipomatous hypertrophy of cardiac interatrial septum. Arch Pathol. 1964;78:11–15
  93. Reyes CV, Jablokow VR. Lipomatous hypertrophy of the cardiac interatrial septum: a report of 38 cases and review of the literature. Am J Clin Pathol. 1979;72:785–788
  94. O'Connor S, Recavarren R, Nichols LC, et al. Lipomatous hypertrophy of the interatrial septum: an overview. Arch Pathol Lab Med. 2006;130:397–399
  95. Burke A, Li L, Kling E, et al. Cardiac inflammatory myofibroblastic tumor: a “benign” neoplasm that may result in syncope, myocardial infarction, and sudden death. Am J Surg Pathol. 2007;31:1115–1122
  96. Butany J, Dixit V, Leong SW, et al. Inflammatory myofibroblastic tumor with valvular involvement: a case report and review of the literature. Cardiovasc Pathol. 2007;16:359–364
  97. Li L, Cerilli LA, Wick MR. Inflammatory pseudotumor (myofibroblastic tumor) of the heart. Ann Diagn Pathol. 2002;6:116–121
  98. Das Narla L, Siddiqi NH, Hingsbergen EA. Inflammatory pseudotumor of the right atrium. Pediatr Radiol. 2001;31:351–353
  99. Stark P, Sandbank JC, Rudnicki C, et al. Inflammatory pseudotumor of the heart with vasculitis and venous thrombosis. Chest. 1992;102:1884–1885
  100. Pucci A, Valori A, Muscio M, et al. Asymptomatic inflammatory myofibroblastic tumor of the heart: immunohistochemical profile, differential diagnosis, and review of the literature. Cardiovasc Pathol. 2009;18:187–190
  101. Kelly SJ, Lambie NK, Singh HP. Inflammatory myofibroblastic tumor of the left ventricle in an older adult. Ann Thorac Surg. 2003;75:1971–1973
  102. Murdison KA, Septimus S, Garola RE, et al. Intracardiac inflammatory myofibroblastic tumor: a unique presentation. Eur J Cardiothorac Surg. 2007;31:750–752
  103. Farrell DJ, Bulmer E, Angus B, et al. Immunohistochemical expression of endothelial markers in left atrial myxomas: a study of six cases. Histopathology. 1996;28:147–152
  104. Ferbend P, Abramson LP, Backer CL, et al. Cardiac plasma cell granulomas: response to oral steroid treatment. Pediatr Cardiol. 2004;25:406–410
  105. Reynolds C, Tazelaar HD, Edwards WD. Calcified amorphous tumor of the heart (cardiac CAT). Hum Pathol. 1997;28:601–606
  106. Forman MB, Virmani R, Robertson RM, et al. Mitral annular calcification in chronic renal failure. Chest. 1984;85:367–371
  107. Morishima A, Sasahashi N, Ueyama K. Calcified amorphous tumors with excision in hemodialysis patients: report of 2 cases. Kyobu Geka. 2006;59:851–854
  108. Fealey ME, Edwards WD, Reynolds CA, et al. Recurrent cardiac calcific amorphous tumor: the CAT had a kitten. Cardiovasc Pathol. 2007;16:115–118
  109. Lewin M, Nazarian S, Marine JE, et al. Fatal outcome of a calcified amorphous tumor of the heart (cardiac CAT). Cardiovasc Pathol. 2006;15:299–302
  110. Burke AP, Anderson PG, Virmani R, et al. Tumor of the atrioventricular nodal region. A clinical and immunohistochemical study. Arch Pathol Lab Med. 1990;114:1057–1062
  111. Saito S, Kobayashi J, Tagusari O, et al. Successful excision of a cystic tumor of the atrioventricular nodal region. Circ J. 2005;69:1293–1294
  112. Cameselle-Teijeiro J, Abdulkader I, Soares P, et al. Cystic tumor of the atrioventricular node of the heart appears to be the heart equivalent of the solid cell nests (ultimobranchial rests) of the thyroid. Am J Clin Pathol. 2005;123:369–375
  113. Wong J, Ball RY. Endodermal heterotopia of the atrioventricular node associated with transposition of the great arteries. Cardiovasc Pathol. 2003;12:159–162
  114. Wolf PL, Bing R. The smallest tumor which causes sudden death. J Am Med Assoc. 1965;8:204–205
  115. Evans CA, Suvarna SK. Cystic atrioventricular node tumour: not a mesothelioma. J Clin Pathol. 2005;58:1232
  116. Fine G, Raju U. Congenital polycystic tumor of the atrioventricular node (endodermal heterotopia, mesothelioma): a histogenetic appraisal with evidence for its endodermal origin. Hum Pathol. 1987;18:791–795
  117. Tanimura A, Kato M, Morimatsu M. Cardiac hamartoma. Acta Pathol Jpn. 1988;38:1481–1484
  118. Burke AP, Ribe JK, Bajaj AK. Hamartoma of mature cardiac myocytes. Hum Pathol. 1998;29:904–909
  119. Sturtz CL, Abt AB, Leuenberger VA, et al. Hamartoma of mature cardiac myocytes: a case report. Mod Pathol. 1998;11:496–499
  120. Fealey ME, Edwards WD, Miller DV, et al. Hamartomas of mature cardiac myocytes: report of 7 new cases and review of literature. Hum Pathol. 2008;39:1064–1071
  121. Martinez Quesada M, Trujillo Berraguero F, Almendro Delia M, et al. Cardiac hamartoma. Case report and literature review. Rev Esp Cardiol. 2005;58:450–542
  122. Voth D. Über die Arachnocytose des Herzmuskels. Frank Zschr Z Pathol. 1962;71:646–656
  123. Gilbert-Barness E. Review: metabolic cardiomyopathy and conduction system defects in children. Ann Clin Lab Sci. 2004;34:15–34
  124. Aksglaede L, Graem N, Jacobsen JR. Histiocytoid cardiomyopathy: a rare cause of ventricular tachycardia and sudden cardiac death in small children. Ugeskr Laeger. 2006;168:61–62
  125. Prahlow JA, Teot LA. Histiocytoid cardiomyopathy: case report and literature review. J Forensic Sci. 1993;38:1427–1435
  126. Edston E, Perskvist N. Histiocytoid cardiomyopathy and ventricular non-compaction in a case of sudden death in a female infant. Int J Legal Med. 2009;123:47–53
  127. Ruszkiewicz AR, Vernon-Roberts E. Sudden death in an infant due to histiocytoid cardiomyopathy. A light-microscopic, ultrastructural, and immunohistochemical study. Am J Forensic Med Pathol. 1993;16:74–80
  128. Lee JH, Kang SK, Lee CW, et al. Giant left atrial ball thrombus in a patient with chronic nonvalvular atrial fibrillation. Ann Thorac Surg. 2008;85:313–315
  129. Mogulkoc N, Burgess MI, Bishop PW. Intracardiac thrombus in Behcets disease: a systematic review. Chest. 2000;118:479–487
  130. Aguilar JA, Summerson C. Intracardiac thrombus in antiphospholipid antibody syndrome. J Am Soc Echocardiogr. 2000;13:873–875
  131. Chartier L, Bera J, Delomez M, et al. Free-floating thrombi in the right heart: diagnosis, management, and prognostic indexes in 38 consecutive patients. Circulation. 1999;99:2779–2783
  132. Fontaine V, Touat Z, Mtairag el M, et al. Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus. Am J Pathol. 2004;164:2077–2087
  133. Araoz PA, Mulvagh SL, Tazelaar HD, et al. CT and MR imaging of benign primary cardiac neoplasms with echocardiographic correlation. Radiographics. 2000;20:1303–1319
  134. Lack EE. Tumors of the adrenal gland and extra-adrenal paraganglia. In:  Rosai J editors. Atlas of tumor pathology. 3rd series. Fascicle 19. Washington (DC): Armed Forces Institute of Pathology; 1997;p. 269–282
  135. Jebara VA, Uva MS, Farge A, et al. Cardiac pheochromocytomas. Ann Thorac Surg. 1992;53:356–361
  136. Kennelly R, Aziz R, Toner M, et al. Right atrial paraganglioma: an unusual primary cardiac tumour. Eur J Cardiothorac Surg. 2008;33:1150–1152
  137. Maxey TS, Grow P, Morris CD, et al. Biatrial primary cardiac paraganglioma: a rare finding. Cardiovasc Pathol. 2007;16:179–182
  138. Turley A, Hunter S, Stewart M. A cardiac paraganglioma presenting with atypical chest pain. Eur J Cardiothorac Surg. 2005;28:352–354
  139. Cane M, Berrizbeitia L, Yang S, et al. Paraganglioma of the interatrial septum. Ann Thorac Surg. 1996;61:1845–1847
  140. Del Fante FM, Watkins E. Chemodectoma of the heart in a patient with multiple chemodectomas and familial history: case report and survey of the literature. Lahey Clin Found Bull. 1967;16:224–229
  141. Neumann HP, Bausch B, McWhinney SR, et al. Germ-line mutations in nonsyndromic pheochromocytoma. N Engl J Med. 2002;346:1459–1466
  142. Mandak JS, Benoit CH, Starkey RH, et al. Echocardiography in the evaluation of cardiac pheochromocytoma. Am Heart J. 1996;132:1063–1066
  143. Mikolaenko I, Galliani CA, Davis GG. Pigmented cardiac paraganglioma. Arch Pathol Lab Med. 2001;125:680–682
  144. Luthringer DJ, Virmani R, Weiss SW, et al. A distinctive cardiovascular lesion resembling histiocytoid (epithelioid) hemangioma: evidence suggesting mesothelial participation. Am J Surg Pathol. 1990;14:993–1000
  145. Pham TT, Antons K, Shishido R, et al. A case of mesothelial/monocytic cardiac excrescence causing severe acute cardiopulmonary failure. Am J Surg Pathol. 2005;29:564–567
  146. Wu M, Anderson A, Kahn LB. A report of mesothelial/monocytic incidental cardiac excrescences and a literature review. Ann Diagn Pathol. 2000;4:39–43
  147. Argani P, Sternberg SS, Burt M, et al. Metastatic adenocarcinoma involving a mesothelial/monocytic incidental cardiac excrescence (cardiac MICE). Am J Surg Pathol. 1997;21:970–974
  148. Veinot JP, Tazelaar HD, Edwards WD, et al. Mesothelial/monocytic incidental cardiac excrescences: cardiac MICE. Mod Pathol. 1994;7:9–16
  149. Natarajan S, Luthringer DJ, Fishbein MC. Adenomatoid tumor of the heart: report of a case. Am J Surg Pathol. 1997;21:1378–1380
  150. Kirma C, Izgi A, Yakut C, et al. Primary left ventricular angiomatosis: first description of a rare vascular tumor in the left heart. Int Heart J. 2006;47:469–474
  151. Shimizu M, Manabe T, Tazelaar HD, et al. Intramyocardial angiomyolipoma. Am J Surg Pathol. 1994;18:1164–1169
  152. Jacob B, Haarhoff K, Neuen-Jacob E, et al. Unexpected infant death attributable to cardiac tumor or cardiomyopathy. Immunohistochemical and electron microscopical findings in three cases. Z Rechtsmed. 1990;103:335–343
  153. Fenoglio JJ, McAllister HA. Granular cell tumors of the heart. Arch Pathol Lab Med. 1976;100:276–278
  154. Kim SJ, Shin ES, Kim SW, et al. A case of cardiac lymphangioma presenting as a cystic mass in the right atrium. Yonsei Med J. 2007;48:1043–1047
  155. Novak PM, Robbins TO, Winkelmann RK. Necrobiotic xanthogranuloma with myocardial lesions and nodular transformation of the liver. Hum Pathol. 1992;23:195–196
  156. Sevimli S, Erkut B, Becit N, et al. Primary benign schwannoma of the left ventricle coursing under the left anterior descending artery. Echocardiogr. 2007;24:1093–1095
  157. Orlandi A, Ferlosio A, Ciucci A, et al. Unusual cardiac tumour with perivascular myoid differentiation: a case report. J Clin Pathol. 2004;57:1338–1340
  158. Patel A, Rigsby C, Young L. Cardiac teratoma of the interventricular septum with congenital aortic stenosis in a newborn. Pediatr Cardiol. 2008;29:1126–1128

PII: S1092-9134(09)00171-3

doi: 10.1016/j.anndiagpath.2009.12.010

Annals of Diagnostic Pathology
Volume 14, Issue 3 , Pages 215-230 , June 2010