Annals of Diagnostic Pathology
Volume 15, Issue 2 , Pages 140-144, April 2011

Papillary carcinoma with diffuse papillomatosis of gallbladder and cystic duct

  • Kemal Kosemehmetoglu, MD

      Affiliations

    • Department of Pathology, Hacettepe University, 06100 Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 312 305 1563; fax: +90 312 305 2621.
    • ,
  • Erhan Akpinar, MD

      Affiliations

    • Department of Radiology, Hacettepe University, 06100 Ankara, Turkey
    • ,
  • Cenk Sokmensuer, MD

      Affiliations

    • Department of Pathology, Hacettepe University, 06100 Ankara, Turkey
    • ,
  • Erhan Hamaloglu, MD

      Affiliations

    • Department of Surgery, Hacettepe University, 06100 Ankara, Turkey

published online 30 April 2010.

Abstract 

Biliary papillomatosis and papillary carcinoma are rare tumors of biliary tract; and because of their morphologic similarities, papillomatosis-papillary carcinoma sequel has been proposed. We report an unusual case of polypoid minimally invasive papillary carcinoma located at the junction between cystic and common bile ducts, complicated with biliary papillomatosis of gallbladder and cystic duct, showing focal areas of malignant change. Intrahepatic ducts, hepatic ducts, and distal common bile duct were spared. Both papillomatosis and papillary carcinoma showed areas of high p53 and p21 expression with high proliferative index. Patient is still alive for 4 years without evidence of disease after modified Whipple operation. Possible pathogenetic mechanisms are further discussed.

Keywords: Papillomatosis, Gallbladder, Papillary carcinoma, p53, MDM2, p21, Ki67

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PII: S1092-9134(10)00024-9

doi:10.1016/j.anndiagpath.2010.02.004

Annals of Diagnostic Pathology
Volume 15, Issue 2 , Pages 140-144, April 2011

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