Annals of Diagnostic Pathology
Volume 15, Issue 3 , Pages 207-212 , June 2011

Malignant pulmonary epithelioid hemangioendothelioma with hilar lymph node metastasis

  • Naobumi Tochigi

      Affiliations

    • Pathology Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
    • ,
  • Koji Tsuta

      Affiliations

    • Clinical Laboratory Division, National Cancer Center Hospital, Tokyo 104-0045, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 3 3542 2511; fax: +81 3 3545 3567.
    • ,
  • Akiko Miyagi Maeshima

      Affiliations

    • Clinical Laboratory Division, National Cancer Center Hospital, Tokyo 104-0045, Japan
    • ,
  • Yasuo Shibuki

      Affiliations

    • Clinical Laboratory Division, National Cancer Center Hospital, Tokyo 104-0045, Japan
    • ,
  • Hisao Asamura

      Affiliations

    • Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo 104-0045, Japan
    • ,
  • Tadashi Hasegawa

      Affiliations

    • Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
    • ,
  • Hitoshi Tsuda

      Affiliations

    • Clinical Laboratory Division, National Cancer Center Hospital, Tokyo 104-0045, Japan

References 

  1. Mentzel T, Beham A, Calonje E, et al. Epithelioid hemangioendothelioma of skin and soft tissues: clinicopathologic and immunohistochemical study of 30 cases. Am J Surg Pathol. 1997;21:363–374
  2. Deyrup AT, Tighiouart M, Montag AG, et al. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol. 2008;32:924–927
  3. Weiss SW, Bridge JA. Epithelioid haemangioendothelioma. In: WHO, Tumours of soft tissue and bone. Lyon: IARCPress; 2002;p. 173–175
  4. Kitaichi M, Nagai S, Nishimura K, et al. Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression. Eur Respir J. 1998;12:89–96
  5. Travis WD, Tazelaar HD, Miettinen M. Epithelioid haemangioendothelioma/angiosarcoma. In: Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC editor. WHO, tumours of the lung, pleura, thymus and heart. Lyon: IARCPress; 2004;p. 97–98
  6. Corrin B, Manners B, Millary M, et al. Histogenesis of the so-called “intravascular bronchioalveolar tumour”. J Pathol. 1979;128:163–167
  7. Dail DH, Liebow AA, Gmelich JT, et al. Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT): an analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer. 1983;51:452–464
  8. Al-Shraim M, Mahboub B, Neligan PC, et al. Primary pleural epithelioid hemangioendothelioma with metastases to skin. A case report and literature review. J Clin Pathol. 2005;58:107–109
  9. Chen TM, Donington J, Mak G, et al. Recurrence of pulmonary intravascular bronchoalveolar tumor with mediastinal metastasis 20 years later. Respir Med. 2006;100:367–370
  10. Endo T, Su CC, Numagami Y, et al. Malignant intracranial EHE presumably originating from the lung: case report. J Neurooncol. 2004;67:337–343
  11. Amin RMS, Hiroshima K, Kokubo T, et al. Risk factors and independent predictors of survival in patients with pulmonary epithelioid haemangioendothelioma. Review of the literature and a case report. Respiology. 2006;11:818–825
  12. Kradin RL, Mark EJ. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 6-2000. EHE of the lung (IVBAT) with lymph-node metastasis. N Engl J Med. 2000;342:572–578
  13. Paciocco G, Caterino U, D'Auria D. Epithelioid hemangioendothelioma of the lung: a high malignancy case. Monaldi Arch Chest Dis. 1999;54:231–233
  14. Riad S, Griffin AM, Liberman B, et al. Lymph node metastasis in soft tissue sarcoma in an extremity. Clin Olthop Relat Res. 2004;426:129–134
  15. Jensen V, Sorensen FP, Bentzen SM, et al. Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytoma: a retrospective immunohistological study including 216 soft tissue sarcomas. Histopathology. 1998;32:536–546
  16. Rossi S, Orvieto E, Furlanetto A, et al. Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody. Mod Pathol. 2004;17:547–552
  17. Dallas NA, Samuel S, Xia L, et al. Endoglin (CD105): a marker of tumor vasculature and potential target for therapy. Clin Cancer Res. 2008;14:1931–1937
  18. Fujii T, Zen Y, Sato Y, et al. Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol. 2008;21:125–130
  19. Hristova EN, Krishnamurthy S, Ro JY, et al. Pulmonary epithelioid hemangioendothelioma with prominent signet ring cell features mimicking metastatic adenocarcinoma. Ann Diagn Pathol. 2003;7:160–164
  20. Lau SK, Luthringer DJ, Eisen RN. Thyroid transcription factor-1: a review. Appl Immunohistochem Mol Morphol. 2002;10:97–102
  21. Gill R, O'Donnell RJ, Horvai A. Utility of immunohistochemistry for endothelial markers in distinguishing epithelioid hemangioendothelioma from carcinoma metastatic to bone. Arch Pathol Lab Med. 2009;133:967–972

PII: S1092-9134(10)00040-7

doi: 10.1016/j.anndiagpath.2010.02.012

Annals of Diagnostic Pathology
Volume 15, Issue 3 , Pages 207-212 , June 2011

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