Annals of Diagnostic Pathology
Volume 14, Issue 5 , Pages 317-320 , October 2010

Hepatocellular carcinoma arising in association with von-Meyenburg's complexes: an incidental finding or precursor lesions? A clinicopatholigic study of 4 cases

  • Deepali Jain, MD, DNB

      Affiliations

    • Department of Pathology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 98688 95112; fax: +91 522 2649389.
    • ,
  • Nabeen C. Nayak, MD

      Affiliations

    • Department of Pathology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India
    • ,
  • Sanjiv Saigal, MD, DNB, DM, MRCP

      Affiliations

    • Department of Gastroenterology, Sir Ganga Ram Hospital, New Delhi 110060, India

References 

  1. Desmet VJ. Congenital diseases of intrahepatic bile ducts: variations on the theme ‘ductal plate malformation’. Hepatology. 1992;16:1069–1083
  2. Rocken C, Pross M, Brucks U, Ridwelski K, Roessner A. Cholangiocarcinoma occurring in a liver with multiple bile duct hamartomas (von Meyenburg complexes). Arch Pathol Lab Med. 2000;124:1704–1706
  3. Heinke T, Pellacani L, de Oliveira Costa H, Fuziy R, Franco M. Hepatocellular carcinoma in association with bile duct hamartomas: report on 2 cases and review of the literature. Ann Diag Pathol. 2008;12:208–211
  4. Papadogiannakis N, Gad A, Sjostedt S, Tour R, Thorne A, Seensalu R. Adenocarcinoid of the liver arising within an area of hamartoma with predominant bile duct component. J Clin Gastroenterol. 1996;23:145–151
  5. Bruegel M, Rummeny EJ, Gaa J. Image of the month. Multiple biliary hamartomas as an incidental finding in a patient with neuroendocrine carcinoma of the pancreas. Gastroenterology. 2005;128:259
  6. Xu AM, Xian ZH, Zhang SH, Chen XF. Intrahepatic cholangiocarcinoma arising in multiple bile duct hamartomas: report of two cases and review of the literature. Eur J Gastroenterol Hepatol. 2009;21:580–584
  7. Kim YW, Park YK, Park JH, et al. A case with intrahepatic double cancer: hepatocellular carcinoma and cholangiocarcinoma associated with multiple von Meyenburg complexes. Yonsei Med J. 1999;40:506–509
  8. Jain D, Sarode VR, Abdul-Karim FW, Homer R, Robert ME. Evidence for the neoplastic transformation of von-Meyenburg complexes. Am J Surg Pathol. 2000;24:1131–1139
  9. Blanc JF, Bernard PH, Carles J, Le Bail B, Balabaud C, Bioulac-Sage P. Cholangiocarcinoma arising in Von Meyenburg complex associated with hepatocellular carcinoma in genetic haemochromatosis. Eur J Gastroenterol Hepatol. 2000;12:233–237
  10. Song JS, Lee YJ, Kim KW, Huh J, Jang SJ, Yu E. Cholangiocarcinoma arising in von Meyenburg complexes: report of four cases. Pathol Int. 2008;58:503–512
  11. Abraham S, Torbenson M. Von-Meyenburg complexes increase with age and are specifically associated with alcoholic cirrhosis and end-stage hepatitis B infection. Lab Investig. 2006;266A:86

PII: S1092-9134(10)00048-1

doi: 10.1016/j.anndiagpath.2010.04.003

Annals of Diagnostic Pathology
Volume 14, Issue 5 , Pages 317-320 , October 2010

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