Amphicrine carcinoma of the liver

Ganesan, Karthik; Achmad, Emil; Sirlin, Claude B.; Bouvet, Michael; Datnow, Brian; Weidner, Noel; Peterson, Michael R.

doi:10.1016/j.anndiagpath.2010.05.001

« Previous Next »Annals of Diagnostic Pathology
Volume 15, Issue 5 , Pages 355-357, October 2011

Amphicrine carcinoma of the liver☆

Karthik Ganesan, DNB
- Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA 92103, USA
- Piramal Healthcare & Jankharia Imaging, Mumbai, India
Emil Achmad
- Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA 92103, USA
Claude B. Sirlin, MD
- Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA 92103, USA
Michael Bouvet, MD
- Department of Surgery, University of California, San Diego, San Diego, CA 92103, USA
Brian Datnow, MD
- Department of Pathology, University of California, San Diego, San Diego, CA 92103, USA
Noel Weidner, MD
- Department of Pathology, University of California, San Diego, San Diego, CA 92103, USA
Michael R. Peterson, MD, PhD
- Department of Pathology, University of California, San Diego, San Diego, CA 92103, USA
- Corresponding author. Tel.: +1 619 543 3265; fax: +1 619 543 5249.

published online 09 July 2010.

Abstract

Amphicrine tumors are defined by evidence of both glandular and neuroendocrine differentiation in the same cell. These are extremely rare tumors, with only scattered case reports in the pancreas and stomach. We here report a case of amphicrine carcinoma occurring in apparent isolation in the liver. The tumor was characterized by signet ring cell morphology, mucicarmine, and periodic acid Schiff with diastase (PASD) positivity, and expression of chromogranin, synaptophysin, villin, and CDX2. No other tumor was identified by radiological or endoscopic examination of the gastrointestinal tract. The patient is disease-free 22 months after the resection. We speculate that this represents the first reported occurrence of primary amphicrine carcinoma of the liver.

Keywords: Liver, Amphicrine, Carcinoma