Changing trends in human papillomavirus–associated head and neck squamous cell carcinoma

Nonkeratinizing squamous cell carcinoma composed of invasive sheets, nests, or trabeculae of tumor cells with squamous differentiation but no evidence of distinct keratinization (A). Keratinizing squamous cell carcinoma composed of recognizable squamous tumor cells with pronounced keratinization (B) (original magnification ×200).

Dark blue punctate (dotlike, A) or diffuse nuclear staining patterns (single or multiple intranuclear spots of variable size, B) of hrHPV-positive tumor cells (original magnification ×400).